Studies on correlations between immunophenotype and the indices of metabolic enzyme activity of blood lymphocytes in children with hypertrophy of the pharyngeal tonsils
https://doi.org/10.15789/1563-0625-SOC-1806
Abstract
The objective of our study was to evaluate correlation between the immune pheno-type and activity indices of NAD (P)-dependent dehydrogenases in peripheral blood lymphocytes in young children with hypertrophy of the pharyngeal tonsil (HPT). We have examined 57 children, 1-3 years of age, with hypertrophy of the pharyngeal tonsils (HPT). The control group consisted of 35 healthy children of the same age. The numbers of CD3+, CD4+, CD8+, CD19+, CD16+/56+ lymphoid cells in peripheral blood were determined by flow cytofluorimetry technique. Activity of NAD (P)-dependant dehydrogenases in peripheral blood lymphocytes was studied using bioluminescent method as described elsewhere (А. Savchenko, L. Suntsova, 1989). Correlation analysis has revealed an increase of positive correlations, a decrease of the correlation strength, and emergence of new connections between phenotype and activity indices of NAD (P)-dependent dehydrogenases in peripheral blood lymphocytes in children with hypertrophy of pharyngeal tonsils (HPT). Specific correlation patterns between the phenotype and activity indices of NAD (P)-dependent dehydrogenases in peripheral blood lymphocytes have been revealed in children with hypertrophy of pharyngeal tonsils (HPT).
About the Authors
L. M. Kurtasova
Krasnoyarsk State V. Voyno-Yasenetsky Medical University;
Krasnoyarsk Regional Center for AIDS Prevention and Control
Russian Federation
Russian Federation
Kurtasova L.M., PhD, MD (Medicine), Professor, Department of Clinical Immunology
660022, Krasnoyarsk, Partizan Zheleznyak str., 1.
N. A. Shakina
Krasnoyarsk Regional Center for AIDS Prevention and Control
Russian Federation
Russian Federation
Shakina N.A., PhD (Medicine), Doctor for Clinical Laboratory Diagnostics, Department of Immunological and Haematological Research
Krasnoyarsk
T. V. Lubnina
Krasnoyarsk Regional Center for AIDS Prevention and Control
Russian Federation
Russian Federation
Lubnina T.V., Clinical Pediatrician, Clinical Ambulance Department
Krasnoyarsk
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For citations:
Kurtasova L.M., Shakina N.A., Lubnina T.V. Studies on correlations between immunophenotype and the indices of metabolic enzyme activity of blood lymphocytes in children with hypertrophy of the pharyngeal tonsils. Medical Immunology (Russia). 2020;22(1):165-170. (In Russ.) https://doi.org/10.15789/1563-0625-SOC-1806
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