Clinical and immunological characteristic of natural course at the early stages of HIV infection
https://doi.org/10.15789/1563-0625-CAI-1866
Abstract
An early-stage infection induces the most powerful reactions of immune system. 137 clinical histories of patients with HIV infection, and HCV/HIV-infected at the early stages of HIV infection were subjected to analysis. Patients and methods: a group of 45 patients at early terms of HIV infection included 25 cases of HCV/HIV-infected patients (first group), and 20 cases with HIV mono-infection (second group). Duration of infection was less than 1 year (with positive ELISA test), with mean terms of HIV immunoblot positivity of 5.5±0.6 months. For comparative analysis, the natural course group was examined, i.e., 43 patients with combined HCV/HIV infection (third group), and 49, with HIV monoinfection (fourth group) with a duration of HIV infection for 4.4±0.21 years. The group of healthy controls included 52 persons. We aimed to perform a comparative evaluation of clinical course and immunological features from the early stages of infection in the patients with combined HCV/HIV and HIV infection. Results: at early stages of infection, clinical pattern in HCV/HIV-infected patients was dominated by purulent-inflammatory, fungal infections and secondary diseases, along with more pronounced inhibition of cellular immunity and increased viral load of RNA HIV, as compared to data on HIV-infected patients.
About the Authors
E. R. Manapova
Kazan State Medical University
Russian Federation
Russian Federation
Manapova Elvira R., PhD, MD (Medicine), Associate Professor, of Department of Infectious Diseases
420012, Republic of Tatarstan, Kazan, Butlerov str., 49
Phone: 7 (917) 294-66-63
V. Kh. Fazylov
Kazan State Medical University
Russian Federation
Russian Federation
PhD, MD (Medicine), Professor, Department of Outpatient Therapy and General Medical Practice
Kazan
A. T. Beshimov
Republican Center for the Prevention and Control of AIDS and Infectious Diseases
Russian Federation
Russian Federation
PhD (Medicine), Deputy Chief Physician of Outpatient Clinic
Kazan
References
1. Ketlinsky S.A., Simbirtsev A.S. Cytokines. St. Petersburg: Foliant, 2008. 552 p.
2. Frater J., Ewings F., Hurst J., Brown H., Robinson N., Fidler S., Babiker A., Weber J., Porter K., Phillips R.E. HIV-1-specific CD4(+) responses in primary HIV-1 infection predict disease progression. AIDS, 2014, Vol. 28, no. 5, pp. 699-708.
3. Goeser F., Glassner A., Kokordelis P., Wolter F., Lutz P., Kaczmarek D.J., Schwarze-Zander C., Boesecke C., Strassburg C.P., Rockstroh J.K., Spengler U., Kramer B., Nattermann J. HIV mono-infection is associated with an impaired anti-hepatitis C virus activity of natural killer cells. AIDS, 2016, Vol. 30, no. 3, pp. 355-363.
4. Gonzalez V.D., Falconer K., Blom K.G., Reichard O., Mørn B., Laursen A.L., Weis N., Alaeus A., Sandberg J.K. High levels of chronic immune activation in the T-cell compartments of patients coinfected with hepatitis C virus and human immunodeficiency virus type 1 and on highly active antiretroviral therapy are reverted by alpha interferon and ribavirin treatment. J. Virol., 2009, Vol. 83, no. 21, pp. 11407-11411.
5. Grivennikov S.I., Greten F.R., Karin M. Immunity, inflammation, and cancer. Cell, 2010, Vol. 140, no. 6, pp. 883-899.
6. Hernandez M.D., Sherman K.E. HIV/hepatitis C coinfection natural history and disease progression. Curr. Opin. HIV AIDS, 2011, Vol. 6, no. 6, pp. 478-482.
7. Hunt P.W. HIV and inflammation: mechanisms and consequences. CurrHIV/AIDS Rep., 2012, Vol. 9, no. 2, pp. 139-147.
8. Kim A.Y., Chung R.T. Coinfection with HIV-1 and HCV – a one-two punch. Gastroenterology, 2009, Vol. 137, no. 3, pp. 795-814.
9. Kovacs A., Karim R., Mack W.J., Xu J., Chen Z., Operskalski E., Frederick T., Landay A., Voris J., Spencer L.S., Young M.A., Tien P.C., Augenbraun M., Strickler H.D., Al-Harthi L. Activation of CD8 T cells predicts progression of HIV infection in women coinfected with HCV virus. J. Infect. Dis., 2010, Vol. 201, no. 6, pp. 823-834.
10. Maenetje P., Riou C., Casazza J.P., Ambrozak D., Hill B., Gray G., Koup R.A., de Bruyn G., Gray C.M. A steady state of CD4 + T cell memory maturation and activation is established during primary subtype C HIV-1 infection. J. Immunol., 2010, Vol. 184, no. 9, pp. 4926-4935.
11. Riou C., Ganusov V.V., Campion S., Mlotshwa M., Liu M.K., Whale V.E., Goonetilleke N., Borrow P., Ferrari G., Betts M.R., Haynes B.F., McMichael A.J., Gray CM. Distinct kinetics of Gag-specific CD4 + and CD8 + T cell responses during acute HIV-1 infection. J. Immunol., 2012, Vol. 188, no. 5, pp. 2198-2206.
12. Rosenberg E.S., Altfeld M., Poon S.H., Phillips M.N., Wilkes B.M., Eldridge R.L., Robbins G.K., d’Aquila R.T., Goulder P.J., Walker B.D. Immune control of HIV-1 after early treatment of acute infection. Nature, 2000, Vol. 407, no. 6803, pp. 523-526.
13. Schieffer M., Jessen H.K., Oster A.F., Pissani F., Soghoian D.Z., Lu R., Jessen A.B., Zedlack C., Schultz B.T., Davis I., Ranasinghe S., Rosenberg E.S., Alter G., Schumann R.R., Streeck H. Induction of Gag-specific CD4 T cell responses during acute HIV infection is associated with improved viral control. J. Virol., 2014, Vol. 88, no. 13, pp. 7357-7366.
14. Serrano-Villar S., Pérez-Elías M.J., Dronda F., Casado J.L., Moreno A., Royuela A., Pérez-Molina J.A., Sainz T., Navas E., Hermida J.M., Quereda C., Moreno S. Increased risk of serious non-AIDS-related events in HIV-infected subjects on antiretroviral therapy associated with a low CD4/CD8 ratio. PLoS ONE, 2014, Vol. 9, no. 1, e85798. doi: 10.1371/journal.pone.0085798.
15. Tassiopoulos K., Landay A., Collier A.C., Connick E., Deeks S.G., Hunt P., Lewis D.E., Wilson C., Bosch R. CD28-negative CD4 + and CD8 + T cells in antiretroviral therapy naive HIV-infected adults enrolled in adult clinical trials group studies. J. Infect. Dis., 2012, Vol. 205, no. 11, pp. 1730-1738.
16. Ward H., Ronn M. Contribution of sexually transmitted infections to the sexual transmission of HIV. Curr. Opin. HIV AIDS, 2010, Vol. 5, no. 4, pp. 305-310.
17. Yin L., Hou W., Liu L., Cai Y., Wallet M.A., Gardner B.P., Chang K., Lowe A.C., Rodriguez C.A., Sriaroon P., Farmerie W.G., Sleasman J.W., Goodenow M.M. IgM repertoire biodiversity is reduced in HIV-1 infection and systemic lupus erythematosus. Front. Immunol., 2013, Vol. 4, 373. doi: 10.3389/fimmu.2013.00373.
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For citations:
Manapova E.R., Fazylov V.Kh., Beshimov A.T. Clinical and immunological characteristic of natural course at the early stages of HIV infection. Medical Immunology (Russia). 2020;22(3):519-526. (In Russ.) https://doi.org/10.15789/1563-0625-CAI-1866
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