ГЕНЕТИЧЕСКИЕ ФАКТОРЫ В ИММУНОПАТОГЕНЕЗЕ ПСОРИАЗА И ПСОРИАТИЧЕСКОГО АРТРИТА
Аннотация
Существует генетически обусловленная предрасположенность к развитию псориаза (ПС) и псориатического артрита (ПсА), в которой существенное значение имеют гены цитокинов. Идентификация полиморфных вариантов генов иммунного ответа (генов цитокинов и их рецепторов) – перспективное направление в изучении генетических факторов риска развития воспаления в коже и суставах при ПС и ПсА. В иммунопатогенезе псориаза и псориатического артрита ведущими являются иммунные нарушения, характеризующиеся девиацией цитокинового профиля по Th1-типу (IL- 2, IFNγ, TNFα). В обзоре проведен анализ данных литературы, раскрывающих роль полиморфизма генов цитокинов в ассоциации с характером течения ПС и ПсА. Поиск генетических маркеров риска развития ПС и ПсА является важным шагом персонализированного подхода к прогнозу течения заболевания и формированию профилактических мероприятий с целью предупреждения прогрессирования патологического процесса.
Об авторах
М. В. Смольникова
ФГБУ «Научно-исследовательский институт медицинских проблем Севера» СО РАМН, г. Красноярск
Россия
Россия
к.б.н., ведущий научный сотрудник, лаборатория клеточно-молекулярной физиологии и патологии ФГБУ «Научно-исследовательский институт медицинских проблем Севера» СО РАМН
С. В. Смирнова
ФГБУ «Научно-исследовательский институт медицинских проблем Севера» СО РАМН, г. Красноярск
Россия
Россия
д.м.н., профессор, заместитель директора по научной работе, руководитель отдела клинической иммунологии и клеточных технологий, ФГБУ «Научно-исследовательский институт медицинских проблем Севера» СО РАМН
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Для цитирования:
Смольникова М.В., Смирнова С.В. ГЕНЕТИЧЕСКИЕ ФАКТОРЫ В ИММУНОПАТОГЕНЕЗЕ ПСОРИАЗА И ПСОРИАТИЧЕСКОГО АРТРИТА. Медицинская иммунология. 2014;16(3):211-220. https://doi.org/10.15789/1563-0625-2014-3-211-220
For citation:
Smolnikova M.V., Smirnova S.V. GENETIC FACTORS IN IMMUNOPATHOGENESIS OF PSORIASIS AND PSORIATIC ARTHRITIS. Medical Immunology (Russia). 2014;16(3):211-220. (In Russ.) https://doi.org/10.15789/1563-0625-2014-3-211-220
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