mimmunМедицинская иммунологияMedical Immunology (Russia)1563-06252313-741XSPb RAACI10.15789/1563-0625-2014-3-211-220mimmun-686Research ArticleОБЗОРЫREVIEWSГЕНЕТИЧЕСКИЕ ФАКТОРЫ В ИММУНОПАТОГЕНЕЗЕ ПСОРИАЗА И ПСОРИАТИЧЕСКОГО АРТРИТАGENETIC FACTORS IN IMMUNOPATHOGENESIS OF PSORIASIS AND PSORIATIC ARTHRITISСмольниковаМ. В.SmolnikovaM. V.

к.б.н., ведущий научный сотрудник, лаборатория клеточно-молекулярной физиологии и патологии ФГБУ «Научно-исследовательский институт медицинских проблем Севера» СО РАМН

PhD (Biology), Leading Research Associate, Laboratory of cellular molecular physiology and pathology, Research Institute for Medical Problems of the North, Siberian Branch of Russian Academy of Medical Sciences

smarinv@ya.ruСмирноваС. В.SmirnovaS. V.

д.м.н., профессор, заместитель директора по научной работе, руководитель отдела клинической иммунологии и клеточных технологий, ФГБУ «Научно-исследовательский институт медицинских проблем Севера» СО РАМН

PhD, MD (Medicine), Professor, Deputy Director for Research, The head of the Division of Clinical Immunology and Cell Technologies, Research Institute for Medical Problems of the North, Siberian Branch of Russian Academy of Medical Sciences

ФГБУ «Научно-исследовательский институт медицинских проблем Севера» СО РАМН, г. КрасноярскРоссияResearch Institute for Medical Problems of the North, Siberian Branch of Russian Academy of Medical Sciences, KrasnoyarskRussian Federation201401082014163211220Copyright © Смольникова М.В., Смирнова С.В., 20142014Смольникова М.В., Смирнова С.В.Smolnikova M.V., Smirnova S.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.mimmun.ru/mimmun/article/view/686

Существует генетически обусловленная предрасположенность к развитию псориаза (ПС) и псориатического артрита (ПсА), в которой существенное значение имеют гены цитокинов. Идентификация полиморфных вариантов генов иммунного ответа (генов цитокинов и их рецепторов) – перспективное направление в изучении генетических факторов риска развития воспаления в коже и суставах при ПС и ПсА. В иммунопатогенезе псориаза и псориатического артрита ведущими являются иммунные нарушения, характеризующиеся девиацией цитокинового профиля по Th1-типу (IL- 2, IFNγ, TNFα). В обзоре проведен анализ данных литературы, раскрывающих роль полиморфизма генов цитокинов в ассоциации с характером течения ПС и ПсА. Поиск генетических маркеров риска развития ПС и ПсА является важным шагом персонализированного подхода к прогнозу течения заболевания и формированию профилактических мероприятий с целью предупреждения прогрессирования патологического процесса.

There is a genetic predisposition to psoriasis (PS) and psoriatic arthritis (PsA), in which some cytokine genes are involved. Identification of polymorphic variants of immune response genes (i.e.,cytokines and their specific receptors) is a promising direction for studies of genetic risk factors responsible for development of skin and joint inflammation in psoriasis and PsA. Immune disorders characterized by the deviation of cytokine profile by Th1-type (IL-2, IFNγ, TNFα) play a leading role in immunopathogenesis ofpsoriasis and psoriatic arthritis. The review deals with analysis of publications regarding the role of cytokine gene polymorphisms associated with clinical course of psoriasis and PsA. Further search for genetic markersdetermining clinical risks of PS and PsA would be an important step in personalized approach to prediction of occurrence and clinical course of the disease, as well as to arrangement of preventive measures, in order to prevent potential progression of the disease.

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The authors declare that there are no conflicts of interest present.