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Медицинская иммунология

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ИММУНОЭПИТОПНЫЙ КОНТИНУУМ РОДСТВА БЕЛКОВ, ПОЛИРЕАКТИВНОСТЬ И АУТОРЕАКТИВНОСТЬ АНТИТЕЛ

https://doi.org/10.15789/1563-0625-2015-4-335-346

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Аннотация

Компьютерный анализ первичных структур более 3300 белков показал возможность существования глобального иммуноэпитопного континуума родства белков (ИЭКРБ) эукариот, прокариот и вирусов. На основе ИЭКРБ можно дать новые трактовки различных феноменов ИС и, в частности, рассматривать его как дополнительный фактор, обусловливающий полиреактивность и аутореактивность антител, и, соответственно, расширить концепцию о регуляторной функции естественных антител. В практических медицинских приложениях опора на существование ИЭКРБ была бы особенно полезной в случае поиска вакцин и иммунодиагностикумов. 

Об авторе

Е. П. Харченко
ФГБУН «Институт эволюционной физиологии и биохимии им. И.М. Сеченова» РАН, Санкт-Петербург, Россия
Россия
д.б.н., ведущий научный сотрудник


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Для цитирования:


Харченко Е.П. ИММУНОЭПИТОПНЫЙ КОНТИНУУМ РОДСТВА БЕЛКОВ, ПОЛИРЕАКТИВНОСТЬ И АУТОРЕАКТИВНОСТЬ АНТИТЕЛ. Медицинская иммунология. 2015;17(4):335-346. https://doi.org/10.15789/1563-0625-2015-4-335-346

For citation:


Kharchenko E.P. IMMUNE EPITOPE CONTINUUM OF THE PROTEIN RELATIONSHIPS, POLY- AND AUTOREACTIVITY OF ANTIBODIES. Medical Immunology (Russia). 2015;17(4):335-346. (In Russ.) https://doi.org/10.15789/1563-0625-2015-4-335-346

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