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Медицинская иммунология

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ИММУНОЭПИТОПНЫЙ КОНТИНУУМ РОДСТВА БЕЛКОВ, ПОЛИРЕАКТИВНОСТЬ И АУТОРЕАКТИВНОСТЬ АНТИТЕЛ

https://doi.org/10.15789/1563-0625-2015-4-335-346

Аннотация

Компьютерный анализ первичных структур более 3300 белков показал возможность существования глобального иммуноэпитопного континуума родства белков (ИЭКРБ) эукариот, прокариот и вирусов. На основе ИЭКРБ можно дать новые трактовки различных феноменов ИС и, в частности, рассматривать его как дополнительный фактор, обусловливающий полиреактивность и аутореактивность антител, и, соответственно, расширить концепцию о регуляторной функции естественных антител. В практических медицинских приложениях опора на существование ИЭКРБ была бы особенно полезной в случае поиска вакцин и иммунодиагностикумов. 

Об авторе

Е. П. Харченко
ФГБУН «Институт эволюционной физиологии и биохимии им. И.М. Сеченова» РАН, Санкт-Петербург, Россия
Россия
д.б.н., ведущий научный сотрудник


Список литературы

1. Ашмарин И. П.. Фрейдлин И. С. Гипотеза об антителах как новейших регуляторах физиологических функций, созданных эволюцией. Журнал эволюционной биохимии и физиологии, 1989. Т. 25, № 2. С. 176-181. [Ashmarin I.P., Freidlin I.S.. Hypothesis on antibodies as the latest regulators of physiological functions created by evolution. Zhurnal evolyutsionnoy biokhimii i fiziologii = Journal of Evolutionary Biochemistry and Physiology, 1989, Vol. 25, no. 2, pp. 176-181. (In Russ.)]

2. Харченко Е.П. Эволюционные аспекты оценки возможного числа и источников белковых регуляторов в организме. Журнал эволюционной биохимии и физиологии, 1988. Т. 24. С. 240-249. [Kharchenko E.P. Evolutionary aspects of evaluation of possible number and sources of protein regulators in the organism. Zhurnal evolyutsionnoy biokhimii i fiziologii = Journal of Evolutionary Biochemistry and Physiology, 1989, Vol. 25, no. 2, pp. 240-249. (In Russ.)]

3. Albert M.L., Darnell R.B. Paraneoplastic neurological degenerations: keys to tumor immunity. Nat. Rev. Cancer, 2004, Vol. 4, no. 1, pp. 36-44.

4. Avrameas S. Natural autoantibodies: from ’horror autotoxicus’ to ’gnothi seauton’. Immunol Today, 1991, Vol. 12, pp. 154-159.

5. Avrameas S., Selmi C. J. Natural autoantibodies in the physiology and pathophysiology of the immune system. Autoimmun., 2013, Vol. 41, pp. 46-49.

6. Basler M., Kirk C. J., Groettrup M. The immunoproteasome in antigen processing and other immunological functions. Current Opinion in Immunology, 2012, Vol. 25, pp. 1-7.

7. Blum J.S., Wearsch P.A., Cresswell P. Pathways of Antigen Processing. Annu. Rev. Immunol., 2013, Vol. 31, pp. 443-473.

8. Chemali M., Radtke K., Desjardins M., English L. Alternative pathways for MHC class I presentation:a new function for autophagy. Cell. Mol. Life Sci., 2011, Vol. 68, pp. 1533-1541.

9. Cohen I.R., Hershberg U., Solomon S. Antigen-receptor degeneracy and immunological paradigms. Mol. Immunol., 2004. Vol. 40, pp. 993-996.

10. Crozat K., Vivier E., Dalod M . Crosstalk between components of the innate immune system: promoting anti-microbial defenses and avoiding immunopathologies. Immunological Reviews, 2009, Vol. 227, pp. 129-149.

11. Cui Z., Zhao M.H., Segelmark M., Hellmark T. Natural autoantibodies to myeloperoxidase, proteinase3 and the glomerular basement membrane are present in normal individuals. Kidney Int., 2010, Vol. 78, pp. 590-597.

12. Derbinski J., Gäbler J., Brors B. Promiscuous gene expression in thymic epithelial cells is regulated at multiple levels. JEM, 2005, Vol. 202, no. 1, pp. 33-45.

13. Edelman G.M . Gaily J.A. Degeneracy and complexity in biological sуstems. Proc. Natl Acad. Sci. USA., 2001, Vol. 98. pp. 13763-13768.

14. Eisen H.N., Chakraborty A.K. Evolving concepts of specificity in immunereactions. Proc. Natl. Acad. Sci. USA, 2010, Vol. 107, pp. 22373-2277.

15. Esparza J. A brief history of the global effort to develop a preventive HIV vaccine. Vaccine, 2013, Vol. 31, pp. 3502-3518.

16. Haynes B.F., Moody M.A., Alam M., Bonsignori M., Verkoczy L., Ferrari G., Gao F., Tomaras G.D., Liao H.-X., Kelsoe G. Progress in HIV-1 vaccine development. J. Allergy Clin. Immunol., 2014, Vol. 134, pp. 3-10.

17. Heuer L., Ashwood P., Schauer J., Goines P., Krakowiak P., Hertz-Picciotto I., Hansen R., Croen L.A., Pessah I.N., Van de Water J. Reduced levels of immunoglobulin in children with autism correlates with behavioral symptoms. Autism. Res., 2008, Vol. 1, pp. 275-283.

18. Hoffmann J.A., Kafatos F.C. Janeway C.A., Ezekowitz R.A. Phylogenetic perspectives in innate immunity. Science, 1999, Vol. 284, pp. 1313-1318.

19. Kang J.Y., Lee Jie-Oh. Structural biology of the Toll-like receptor family. Annu. Rev. Biochem., 2011, Vol. 80, pp. 917-941.

20. Kawai T., Akira S. Toll-like receptors and their crosstalk with other innate receptors in infection and immunity. Immunity, 2011, Vol. 34, pp. 637-650.

21. Klein F., Mouquet H., Dosenovic P., Scheid J., Scharf L., Nussenzweig M.C. Antibodies in HIV-1 Vaccine Development and Therapy. Science, 2013, Vol. 341, no. 6151, pp. 1199-1204.

22. Lacroix-Desmazes S, Kaveri S.V., Mouthon L., Ayouba A., Malanchere E., Coutinho A., Kazatchkine M. Selfreactive antibodies (natural autoantibodies) in healthy individuals. J. Immunol. Methods, 1998, Vol. 216, pp. 117-137.

23. Madi A., Bransburg-Zabary S., Kenett D.Y., Ben-Jacob E., Cohen I.R. The natural autoantibody repertoire in newborns and adults: a current overview. Adv. Exp. Med. Biol., 2012, Vol. 750, pp. 198-212.

24. Mathis D., Benoist C. Aire. Annu. Rev. Immunol., 2009, Vol. 27, pp. 287-312.

25. Nagele E.P., Han M., Acharya N.K., DeMarshall C., Kosciuk M.C., Nagele R.G. Natural IgG autoantibodies are abundant and ubiquitous in human sera, and their number is influenced by age, gender, and disease. PLoS ONE, 2013, Vol. 8, no. 4, e60726.

26. Notkins A.L.Polyreactivity of antibody molecules. Trends Immunol., 2004, Vol. 25, pp. 174-179.

27. Paust S., Senman B., von Andrian U.H. Adaptive immune responses mediated by natural killer cells. Immunological Reviews, 2010, Vol. 235, pp. 286-296.

28. Plotkin S.A. Correlates of protection induced by vaccination. Clin. Vaccine Immunol., 2010, Vol. 17, pp. 1055-1065.

29. Pradeu T., Carosella E.D. On the defi nition of a criterion of immunogenicity. Proc. Natl. Acad. Sci. USA, 2006, Vol. 103, pp. 17858-17863.

30. Roberts W.K., Darnell R.B. Neurobiology of the paraneoplastic neurological degenerations. Cur. Opinion Immunol., 2004, Vol. 16, no. 5, pp. 616-622.

31. Rothstein T.L., Griffin D.O., Holodick N.E., Quach T.D., Kaku H. Human B-1 cells take the stage. Annals of the New York Academy of Sciences, (2013), Vol. 1285, pp. 97-114.

32. Schwartz-Albiez R., Monteiro R.C., Rodriguez M., Binder C.J., Shoenfeld Y. Natural antibodies, intravenous immunoglobulin and their role in autoimmunity, cancer and inflammation. Clinical and Experimental Immunology, 2009, Vol.158, Suppl. 1, pp. 43-50.

33. Sijts E.J.A.M., Kloetzel P.-M. The role of the proteasome in the generation of MHC class I ligands and immune responses. Cell. Mol. Life Sci., 2011, Vol. 68, pp. 1491-1502.

34. Smith P.L., Tanner H., Dalgleish A. Developments in HIV-1 immunotherapy and therapeutic vaccination. F1000Prime Reports, 2014, Vol. 6, p. 43. doi: 10.12703/P6-43. eCollection 2014

35. Stritesky G. L., Jameson S.C., Hogquist K. A. Selection of self-reactive Т cells in the thymus. Annu. Rev. Immunol., 2012, Vol. 30, рр. 95-114.

36. Van Regenmortel M. An outdated notion of antibody specificity is one of the major detrimental assumptions of the structure-based reverse vaccinology paradigm, which prevented it from helping to develop an effective HIV-1 vaccine. Frontiers in Immunology, 2014, Vol. 5, pp. 1-8.

37. VanRegenmortel M.H.V. Specificity, polyspecificity and heterospecificity of antibody-antigen recognition. J. Mol. Recognit., 2014, Vol. 27, pp. 627-639.

38. Varbiro S., Biro A., Cervenak J., Cervenak L., Singh M., Banhidy F., Sebestyen A., Füst G., Prohászka Z. Human anti-60 kD heat shock protein autoantibodies are characterized by basic features of natural autoantibodies. Acta Physiologica Hungarica, 2010, Vol. 97, no. 1, pp. 1-10.

39. Vargas M.E., Watanabe J., Singh S.J., Robinson W.H., Barres B.A. Endogenous antibodies promote rapid myelin clearance and effective axon regeneration aſter nerve injury. Proc. Natl. Acad. Sci. USA, 2010, Vol. 107, pp. 11993-11998.

40. Vas J., Gronwall C., Silverman G.J. Fundamental roles of the innate-like repertoire of natural antibodies in immune homeostasis. Frontiers in Immunology, 2013, Vol. 4, Article 4-2.

41. Vita R., Zarebski L., Greenbaum J.A., Emami H., Hoof I., Salimi N., Damle R., Sette A., Peters B. The Immune epitope database 2.0. Nucleic Acids Res., 2010, Vol. 38. Database issue., D854-D862.

42. Wucherpfennig K.W., Allen P.M., Celada F., Cohen I.R., DeBoer R., Garcia K.C.,, Goldstein B., Greenspan R., Hafler D., Hodgkin P., Huseby E.S., Krakauer D.C., Nemazee D., Perelson A.S., Pinilla C., Strong R.K., Sercarz E.E. Polyspecificity of Tcell and B cell receptor recognition. Semin. Immunol., 2007, Vol. 19, pp. 216-224.

43. Xu P.-C., Cui Z., Chen M., Hellmark T., Zhao M.-H. Comparison of characteristics of natural autoantibodies against myeloperoxidase and anti-myeloperoxidase autoantibodies from patients with microscopic polyangiitis. Rheumatology, 2011, Vol. 50, pp. 1236-1243.


Рецензия

Для цитирования:


Харченко Е.П. ИММУНОЭПИТОПНЫЙ КОНТИНУУМ РОДСТВА БЕЛКОВ, ПОЛИРЕАКТИВНОСТЬ И АУТОРЕАКТИВНОСТЬ АНТИТЕЛ. Медицинская иммунология. 2015;17(4):335-346. https://doi.org/10.15789/1563-0625-2015-4-335-346

For citation:


Kharchenko E.P. IMMUNE EPITOPE CONTINUUM OF THE PROTEIN RELATIONSHIPS, POLY- AND AUTOREACTIVITY OF ANTIBODIES. Medical Immunology (Russia). 2015;17(4):335-346. (In Russ.) https://doi.org/10.15789/1563-0625-2015-4-335-346

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