CYTOKINES IN LACRIMAL FLUID AND BLOOD SERUM: EARLY BIOMARKERS OF AGE-RELATED MACULAR DEGENERATION
https://doi.org/10.15789/1563-0625-2015-3-245-252
Abstract
The article presents results of multiplex cytokine assays in blood serum and lacrimal fluid at the initial and intermediate stages of age-related macular degeneration (AMD). Some features of local and systemic disturbances in the cytokine profile were detected in these patients. It was revealed that the initial stage of AMD was associated with elevated IL-17 levels in lacrimal fluid, along with imbalance between the local increase and systemic decrease of TGF-β1 amounts. Intermediate-stage AMD was associated with increased levels of the most cytokines assayed (except of TGF-β1) in blood serum and lacrimal fluid, thus suggesting stimulation of both pro-inflammatory and angiogenic responses, like as activation of anti-inflammatory and anti-infective factors.
About the Authors
O. S. Slepova
H. Helmholtz Research Institute for Ocular Diseases, Moscow
Russian Federation
Russian Federation
PhD, MD (Biology), Professor, Chief, Laboratory of Immunology and Virology.
Address for correspondence: Slepova Olga S. H. Helmholtz Research Institute for Ocular Diseases, Russian Ministry of Health Care 105162,Russian Federation,Moscow, SadovoChernogryazskaya str., 14/19. Phone: 7 (916) 246-97-64. E-mail: slepovaolga@yandex.ru
E. A. Eremeeva
H. Helmholtz Research Institute for Ocular Diseases, Moscow
Russian Federation
Eye Physician, Outpatient Department for Adults
Russian Federation
Eye Physician, Outpatient Department for Adults
M. V. Ryabina
H. Helmholtz Research Institute for Ocular Diseases, Moscow
Russian Federation
PhD (Medicine), Senior Research Associate, Department of Retinal Pathology
Russian Federation
PhD (Medicine), Senior Research Associate, Department of Retinal Pathology
E. S. Sorozhkina
H. Helmholtz Research Institute for Ocular Diseases, Moscow
Russian Federation
Research Associate, Laboratory of Immunology and Virology
Russian Federation
Research Associate, Laboratory of Immunology and Virology
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For citations:
Slepova O.S., Eremeeva E.A., Ryabina M.V., Sorozhkina E.S. CYTOKINES IN LACRIMAL FLUID AND BLOOD SERUM: EARLY BIOMARKERS OF AGE-RELATED MACULAR DEGENERATION. Medical Immunology (Russia). 2015;17(3):245-252. (In Russ.) https://doi.org/10.15789/1563-0625-2015-3-245-252
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