“CVCACS” MODEL FOR PREDICTION OF CARDIOVASCULAR COMPLICATIONS IN HOSPITALIZED PATIENTS WITH ACUTE CORONARY SYNDROME
https://doi.org/10.15789/1563-0625-2015-1-81-86
Abstract
Sixty-eight patients with acute coronary syndrome (ACS) were studied for correlations between the levels of interleukin IL-6 and IL-10 in blood and saliva, highly sensitive C-reactive protein (hs-CRP) and brain natriuretic peptide (NtproBNP) in the blood serum with the development of cardiovascular complications (CVC) during hospital period of the disease. It has been revealed that the patients with CVC had higher concentration of IL-6 in blood, IL-6, IL-10 in saliva, hs-CRP and NtproBNP in blood samples. Meanwhile, excess of IL-6 levels in saliva over those in blood was a significant predictor of CVC development. In order to facilitate the prediction values of CVC during ACS hospital period we have proposed a “CVCACS” model that employed the parameters of patient’s age, IL-10 level in the saliva, IL-6, and hs-CRP amounts in blood. It should be mentioned that the variable value of > -0,657 obtained with “CVCACS” model was predictive for development of CVC during ACS hospital period, while ≤ -0,657 was associated with favorable course of ACS hospital period.
About the Authors
E. T. Manyukova
Municipal Clinical Hospital N 38
603000, Russian Federation, N. Novgorod, Chernyshevsky str., 22.
Russian Federation
Russian Federation
Physician, Municipal Clinical Hospital N 38, N. Novgorod, Russian Federation
M. A. Shalenkova
Municipal Clinical Hospital N 38
603000, Russian Federation, N. Novgorod, Chernyshevsky str., 22.
Russian Federation
Russian Federation
PhD, MD (Medicine), Consulting Physician, Municipal Clinical Hospital N 38, N. Novgorod, Russian Federation
Z. D. Mikhailova
Municipal Clinical Hospital N 38
603000, Russian Federation, N. Novgorod, Chernyshevsky str., 22.
Russian Federation
Competing Interests:
Russian Federation
PhD (Medicine), Consulting Physician, Municipal Clinical Hospital N 38, N. Novgorod, Russian Federation
Competing Interests:
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Review
For citations:
Manyukova E.T., Shalenkova M.A., Mikhailova Z.D. “CVCACS” MODEL FOR PREDICTION OF CARDIOVASCULAR COMPLICATIONS IN HOSPITALIZED PATIENTS WITH ACUTE CORONARY SYNDROME. Medical Immunology (Russia). 2015;17(1):81-86. (In Russ.) https://doi.org/10.15789/1563-0625-2015-1-81-86
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