BLOOD LEVELS OF INTERLEUKIN-6 AND INTERLEUKIN-10 IN SERUM AND BIOMARKERS OF ACUTE KIDNEY INJURY IN ACUTE CORONARY SYNDROME
https://doi.org/10.15789/1563-0625-2015-1-47-52
Abstract
Certain correlations between changes of cytokine levels and kidney dysfunction, as well as their prognostic significance for development of acute kidney injury (АКI) in different clinical forms of ischemic heart disease (IHD) seem to be worth of further studies. The levels of IL-6 and IL-10 and their correlation with serum creatinine (sCr) and lipocalin levels in urine (u-NGAL) were studied in 98 IHD patients, of them 93 presented with acute coronary syndrome (ACS) and 5, with stable angina pectoris. ACS patients were found to have increased levels of IL-6, IL-10, sCr, u-NGAL. IL-6 and IL-10 contents proved to be increased in cases of non-ST-segment elevation ACS (NSTE-ACS), and during AKI development. According to serum creatinin levels, AKI was more frequently revealed in patients with NSTE-ACS. Urinary NGAL levels were found to be higher in ACS with ST segment elevation.
About the Authors
M. A. Shalenkova
Municipal Clinical Hospital N 38
603000, Russian Federation, N. Novgorod, Chernyshevsky str., 22.
Russian Federation
Russian Federation
PhD, MD (Medicine), Consulting Physician, Municipal Clinical Hospital N 38, N. Novgorod, Russian Federation
Z. D. Mikhailova
Municipal Clinical Hospital N 38
603000, Russian Federation, N. Novgorod, Chernyshevsky str., 22.
Russian Federation
Russian Federation
PhD (Medicine), Consulting Physician, Municipal Clinical Hospital N 38, N. Novgorod, Russian Federation
P. F. Klimkin
Municipal Clinical Hospital N 38
603000, Russian Federation, N. Novgorod, Chernyshevsky str., 22.
Russian Federation
Russian Federation
Physician, Municipal Clinical Hospital N 38, N. Novgorod, Russian Federation
E. T. Manyukova
Municipal Clinical Hospital N 38
603000, Russian Federation, N. Novgorod, Chernyshevsky str., 22.
Russian Federation
Russian Federation
Physician, Municipal Clinical Hospital N 38, N. Novgorod, Russian Federation
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For citations:
Shalenkova M.A., Mikhailova Z.D., Klimkin P.F., Manyukova E.T. BLOOD LEVELS OF INTERLEUKIN-6 AND INTERLEUKIN-10 IN SERUM AND BIOMARKERS OF ACUTE KIDNEY INJURY IN ACUTE CORONARY SYNDROME. Medical Immunology (Russia). 2015;17(1):47-52. (In Russ.) https://doi.org/10.15789/1563-0625-2015-1-47-52
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