STUDY OF CYTOKINE PROFILE IN INFLUENZA COMPLICATED BY PNEUMONIA
https://doi.org/10.15789/1563-0625-2014-3-265-272
Abstract
The goal of present study was to perform a comparative evaluation of cytokine levels in blood of 123 patients with uncomplicated influenza versus a group of cases complicated by subsequent pneumonia. Higher levels of TNFα, IL-10, IL-6, IL-8 and lower levels of IFNγ were found in blood serum of those patients who developed pneumonia during acute phase of influenza. We have revealed a correlation between the severity and duration of symptoms of both uncomplicated and pneumonia-conplicated flu, and serum concentrations of proinflammatory (TNFα, IL-1β, IL-6, IL-8) and anti-inflammatory cytokines (IL-1rа, и IL-10), as well as with indexes of interferon profile (antiIFNα, IFNα и IFNγ) in the patients.
About the Authors
L. V. Voloshchuk
Research Institute of Influenza, Ministry of Health Care of Russian Federation, St. Petersburg
Russian Federation
Russian Federation
PhD (Medicine), Senior Research Associate, Division
of Viral Respiratory Infections in Adults, Research Institute of Influenza, Ministry of Health Care of Russian Federation
E. G. Golovacheva
Research Institute of Influenza, Ministry of Health Care of Russian Federation, St. Petersburg
Russian Federation
Russian Federation
Research Associate, Division of Viral Respiratory
Infections in Adults, Research Institute of Influenza, Ministry of Health Care of Russian Federation
A. L. Mushkatina
Research Institute of Influenza, Ministry of Health Care of Russian Federation, St. Petersburg
Russian Federation
Russian Federation
PhD (Medicine), Senior Research Associate, Division of Viral Respiratory Infections in Children, Research Institute of Influenza, Ministry of Health Care of Russian Federation
L. V. Osidak
Research Institute of Influenza, Ministry of Health Care of Russian Federation, St. Petersburg
Russian Federation
Russian Federation
PhD, MD (Medicine), Professor, Leading Research Associate, Division of Viral Respiratory Infections in Children, Research Institute of Influenza, Ministry of Health Care of Russian Federation
P. V. Zarishnuk
Research Institute of Influenza, Ministry of Health Care of Russian Federation, St. Petersburg
Russian Federation
Russian Federation
PhD, MD (Medicine), Senior Research Associate,
Division of Viral Respiratory Infections in Adults, Research Institute of Influenza, Ministry of Health Care of Russian Federation
E. G. Rozhkova
Research Institute of Influenza, Ministry of Health Care of Russian Federation, St. Petersburg
Russian Federation
Russian Federation
PhD (Medicine), Leading Research Associate. Division
of Viral Respiratory Infections in Adults, Research Institute of Influenza, Ministry of Health Care of Russian Federation
T. L. Tumina
Research Institute of Influenza, Ministry of Health Care of Russian Federation, St. Petersburg
Russian Federation
Russian Federation
Research Associate, Division of Viral Respiratory
Infections in Adults, Research Institute of Influenza, Ministry of Health Care of Russian Federation
A. A. Go
Research Institute of Influenza, Ministry of Health Care of Russian Federation, St. Petersburg
Russian Federation
Russian Federation
PhD (Medicine), Chief, Division of Viral Respiratory Infections in Adults Research Institute of Influenza, Ministry of Health Care of Russian Federation
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Review
For citations:
Voloshchuk L.V., Golovacheva E.G., Mushkatina A.L., Osidak L.V., Zarishnuk P.V., Rozhkova E.G., Tumina T.L., Go A.A. STUDY OF CYTOKINE PROFILE IN INFLUENZA COMPLICATED BY PNEUMONIA. Medical Immunology (Russia). 2014;16(3):265-272. (In Russ.) https://doi.org/10.15789/1563-0625-2014-3-265-272
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