СЕКРЕЦИЯ ИНТЕРЛЕЙКИНОВ IL-12, IL-27 МОНОНУКЛЕАРНЫМИ ЛЕЙКОЦИТАМИ И ЭКСПРЕССИЯ ИХ РЕЦЕПТОРОВ НА Т-ЛИМФОЦИТАХ В УСЛОВИЯХ НАПРАВЛЕННОЙ ИНДУКЦИИ КЛЕТОК IN VITRO ПРИ ТУБЕРКУЛЕЗЕ ЛЕГКИХ

В статье представлены результаты исследования у больных туберкулезом легких секреции цитокинов семейства интерлейкина (IL) 12 – IL-12р70, IL-12р40, IL-12р35 и IL-27 мононуклеарными лейкоцитами крови и экспрессии комплементарных им рецепторов на Т-лимфоцитах в условиях направленной (антиген- и цитокин-опосредованной соответственно) индукции клеток in vitro. У больных туберкулезом легких установлено угнетение спонтанной и BCG-индуцированной секреции IL- 12р70 и IL-12р35 на фоне гиперпродукции IL-12р40 и IL-27, снижение относительного количества СD3+gp130+, CD3+IL12Rβ2+ лимфоцитов и увеличение содержания Т-клеток с высокой экспрессией ингибиторной молекулы WSX-1 (CD3+WSX-1+hi) при IL-12/IL-27-индукции in vitro. Показано, что выявленные изменения в большинстве случаев носят однонаправленный характер и варьируют в зависимости от клинической формы заболевания и чувствительности возбудителя инфекции к противотуберкулезным препаратам.

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