INDUCTION OF IL-8 PRODUCTION BY THE METAL COMPLEXES OF γ-GLOBULIN FORMED WITH ZINC IONS
https://doi.org/10.15789/1563-0625-2013-5-431-438
Abstract
Abstract. This study has shown detectable production of IL-8, as a fraction of cytokine pool induced in culture of human peripheral blood cells (PBCs). Mean amounts of IL8 produced in presence of γ-globulin fraction proteins and/or their metal complexes with zinc ions varied from 575.0±27.77 to 6355.0±480.98 pg/ ml. The complexes of γ-globulin with zinc (48 h of culture) caused increase of IL-8 production that was 1.8-fold higher than with control γ-globulin and 1.4-fold higher than with of zinc ions alone (p < 0.02). Dynamic tracking of the cytokine levels has shown that PBCs induced with γ-globulin/metal complexes produced IL8 as a factor of prolonged or late-type response.
About the Authors
M. A. Apresova
Federal State Gamaleya Research Institute for Epidemiology and Microbiology, Russian Ministry of Health Care, Moscow
Russian Federation
Russian Federation
Research Associate, Laboratory of Cell-to-Cell Interactions
I. E. Efremova
Federal State Gamaleya Research Institute for Epidemiology and Microbiology, Russian Ministry of Health Care, Moscow
Russian Federation
Russian Federation
Research Associate, Laboratory of Cellto-Cell Interactions
A. A. Babayants
Federal State Gamaleya Research Institute for Epidemiology and Microbiology, Russian Ministry of Health Care, Moscow
Russian Federation
Russian Federation
PhD (Medicine), Research Associate, Laboratory of Cell-to-Cell Interactions
S. B. Cheknev
Federal State Gamaleya Research Institute for Epidemiology and Microbiology, Russian Ministry of Health Care, Moscow
Russian Federation
Russian Federation
PhD, MD (Medicine), Chief, Laboratory of Cell-to-Cell Interactions, Deputy Director for Research
123098, Gamaleya str., 18. Phone: 7 (499) 190-43-88. Fax: 7 (499) 193-61-83
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Review
For citations:
Apresova M.A., Efremova I.E., Babayants A.A., Cheknev S.B. INDUCTION OF IL-8 PRODUCTION BY THE METAL COMPLEXES OF γ-GLOBULIN FORMED WITH ZINC IONS. Medical Immunology (Russia). 2013;15(5):431-438. (In Russ.) https://doi.org/10.15789/1563-0625-2013-5-431-438
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