STUDYING ASSOCIATIONS OF TWO COMMON S27P AND -15С→T POLYMORPHISMS OF THE INTERLEUKIN-3 GENE WITH DEVELOPMENT OF ALLERGIC AND NON-ALLERGIC BRONCHIAL ASTHMA IN RUSSIANS FROM THE CENTRAL-CHERNOZEM REGION
https://doi.org/10.15789/1563-0625-2006-5-6-731-736
Abstract
Abstract. The purpose of our study was to investigate whether S27P and -15С→T single nucleotide polymorphisms of the IL3 gene are associated with susceptibility to bronchial asthma (BA) in Russians living in the Central-Chernozem region of Russia. DNA samples obtained from 216 unrelated patients with BA and 214 healthy controls were typed for S27P and -15С→T polymorphisms in the IL3 gene by PCR-RFLP methods. Gender-based differences in the distribution of IL3 genotypes have been revealed between controls and patients with asthma. Both S27P and -15С→T polymorphisms were found to associate with common susceptibility to BA predominantly in females (p=0,05). Studied genetic variants of IL3 gene were in strong linkage disequilibrium with each other (p<0,0001). Further studies are required to investigate phenotypic expression of S27P and -15С→T polymorphisms of IL3 gene and to clarify their roles in the pathogenesis of bronchial asthma.
About the Authors
A. V. Polonikov
Курский государственный медицинский университет
Russian Federation
Russian Federation
V. P. Ivanov
Курский государственный медицинский университет
Russian Federation
Russian Federation
D. A. Belugin
Курский государственный университет
Russian Federation
Russian Federation
I. V. Khoroshaya
Курский государственный медицинский университет
Russian Federation
Russian Federation
M. A. Solodilova
Курский государственный медицинский университет
Russian Federation
Russian Federation
V. I. Panfilov
Курская областная клиническая больница, г. Курск
Russian Federation
Russian Federation
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For citations:
Polonikov A.V., Ivanov V.P., Belugin D.A., Khoroshaya I.V., Solodilova M.A., Panfilov V.I. STUDYING ASSOCIATIONS OF TWO COMMON S27P AND -15С→T POLYMORPHISMS OF THE INTERLEUKIN-3 GENE WITH DEVELOPMENT OF ALLERGIC AND NON-ALLERGIC BRONCHIAL ASTHMA IN RUSSIANS FROM THE CENTRAL-CHERNOZEM REGION. Medical Immunology (Russia). 2006;8(5-6):731-736. (In Russ.) https://doi.org/10.15789/1563-0625-2006-5-6-731-736
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