ИЗУЧЕНИЕ СВЯЗИ ДВУХ РАСПРОСТРАНЕННЫХ ПОЛИМОРФИЗМОВ S27P И -15С→T ГЕНА IL3 С РАЗВИТИЕМ АЛЛЕРГИЧЕСКОЙ И НЕАЛЛЕРГИЧЕСКОЙ БРОНХИАЛЬНОЙ АСТМЫ У РУССКИХ ЖИТЕЛЕЙ ЦЕНТРАЛЬНОГО ЧЕРНОЗЕМЬЯ

Резюме. The purpose of our study was to investigate whether S27P and -15С→T single nucleotide polymorphisms of the IL3 gene are associated with susceptibility to bronchial asthma (BA) in Russians living in the Central-Chernozem region of Russia. DNA samples obtained from 216 unrelated patients with BA and 214 healthy controls were typed for S27P and -15С→T polymorphisms in the IL3 gene by PCR-RFLP methods. A genderbased dimorphism in distribution of IL3 genotypes has been revealed for various clinical and pathogenetic BA variants. Both S27P and -15С→T polymorphisms were found to be associated with general susceptibility to BA, predominantly in females (p=0,05). The studied genetic variants of IL3 gene were in strong linkage disequilibrium with each other (p<0,0001). Further studies are required to investigate phenotypic expression of S27P and -15С→T polymorphisms of IL3 gene and to clarify their roles in the pathogenesis of bronchial asthma.

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