CLINICAL AND IMMUNOLOGICAL EFFICIENCY OF BETALEUKIN IN PATIENTS WITH INFLUENZA AND FLU-LIKE DISEASES COMPLICATED BY PNEUMONIA
https://doi.org/10.15789/1563-0625-2013-1-29-36
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Abstract
This investigation was aimed for studying efficacy of Betaleukin in combined therapy of influenza and flu-like respiratory diseases complicated by pneumonia, and development of inclusion criteria. Treatment with Betaleukin was significantly associated with shorter duration of catarrhal syndrome and decreased resolution terms of lung infiltrates. Usage of Betaleukin was shown to influence the levels of pro- and anti-inflammatory cytokines and interferons. Betaleukin is effective in patients under 50 years old, independent on initial volume of lung infiltrates. Full resolution of pneumonia treated with Betaleukin was observed in patients with initial IL-1β concentrations under 80 pg/ml, or 80-120 pg/ml, and IL-1rа concentrations of 500-1000 pg/ml in blood serum.
About the Authors
L. V. Voloschchuk
ФГБУ «НИИ гриппа» Минздрава России, Санкт-Петербург
Russian Federation
Russian Federation
E. G. Golovacheva
ФГБУ «НИИ гриппа» Минздрава России, Санкт-Петербург
Russian Federation
Russian Federation
A. L. Mushkatina
ФГБУ «НИИ гриппа» Минздрава России, Санкт-Петербург
Russian Federation
Russian Federation
L. V. Osidak
ФГБУ «НИИ гриппа» Минздрава России, Санкт-Петербург
Russian Federation
Russian Federation
P. V. Zarishnyuk
ФГБУ «НИИ гриппа» Минздрава России, Санкт-Петербург
Russian Federation
Russian Federation
A. A. Go
ФГБУ «НИИ гриппа» Минздрава России, Санкт-Петербург
Russian Federation
Russian Federation
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Review
For citations:
Voloschchuk L.V., Golovacheva E.G., Mushkatina A.L., Osidak L.V., Zarishnyuk P.V., Go A.A. CLINICAL AND IMMUNOLOGICAL EFFICIENCY OF BETALEUKIN IN PATIENTS WITH INFLUENZA AND FLU-LIKE DISEASES COMPLICATED BY PNEUMONIA. Medical Immunology (Russia). 2013;15(1):29-36. (In Russ.) https://doi.org/10.15789/1563-0625-2013-1-29-36
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ISSN 1563-0625 (Print)
ISSN 2313-741X (Online)
ISSN 2313-741X (Online)
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