ACTIVATION OF CELLS FROM HYPOTHALAMIC STRUCTURES AFTER INJECTION OF ANTIGENS DIFFERENT IN THEIR NATURE (by the c-Fos expression)
https://doi.org/10.15789/1563-0625-2006-5-6-631-636
Abstract
Abstract. Activation levels of hypothalamic structures (AHN, PVH, DMH, VMH, LHA, PH) were analyzed within first hours after injection of antigens [lipopolysaccharide (LPS) and bovine serum albumine [BSA]). For all investigated hypothalamic structures, an increase of c-Fos positive cells numbers was observed after injection of the antigens, as compared to the controls. LPS injection caused activation of more multiple neuron populations. AHN, PVH, LHA, and PH structures exhibited the highest levels of c-Fos activation upon LPS application. BSA injection induced activation of lesser cells quantities, but their enrichment in c-Fos protein was higher, thus resulting into increased optical density of VMH, LHA and PH neurons. Hence, the present work has shown that activation pattern of hypothalamic structures differs upon application of antigens that are different by their origin.
About the Authors
S. V. Perekrest
ГУ НИИ Экспериментальной медицины РАМН, Санкт-Петербург
Russian Federation
Russian Federation
Yu. V. Gavrilov
ГУ НИИ Экспериментальной медицины РАМН, Санкт-Петербург
Russian Federation
Russian Federation
T. V. Abramova
ГУ НИИ Экспериментальной медицины РАМН, Санкт-Петербург
Russian Federation
Russian Federation
N. S. Novikova
ГУ НИИ Экспериментальной медицины РАМН, Санкт-Петербург
Russian Federation
Russian Federation
E. A. Korneva
ГУ НИИ Экспериментальной медицины РАМН, Санкт-Петербург
Russian Federation
Russian Federation
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Review
For citations:
Perekrest S.V., Gavrilov Yu.V., Abramova T.V., Novikova N.S., Korneva E.A. ACTIVATION OF CELLS FROM HYPOTHALAMIC STRUCTURES AFTER INJECTION OF ANTIGENS DIFFERENT IN THEIR NATURE (by the c-Fos expression). Medical Immunology (Russia). 2006;8(5-6):631-636. (In Russ.) https://doi.org/10.15789/1563-0625-2006-5-6-631-636
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