Preview

Medical Immunology (Russia)

Advanced search

REACTOGENITY OF TICK-BORNE ENCEPHALITIS VACCINE ENCEPUR ADULT AND IMMUNE RESPONSE

https://doi.org/10.15789/1563-0625-2005-4-391-396

Abstract

Abstract. The comprehensive clinical-immunological characteristic of a tick-borne encephalitis vaccine En-cepur Adult (Germany), which was studied on a group of residents of Far East of Russia was discussed. Reactogenity in 32,4% of vaccinees was characterized by minor clinical manifestations and was due to the reaction to specific vaccine albumin. Expression of immune response (mean geometric titers) was evaluated in a neutralization test. A group with the reactogenity showed higher geometric mean antibody titers (1:182) compared with a group without the reactogenity (1:97).

All of vaccinees with various levels (high, middle, low) of specific immune response had an increased quantity of CD20+ and CD25+ lymphocytes. We showed a difference in immunologic reactivity of people with high and low levels of specific antibody response. As compared with a low level group the group with a high level of specific response showed significantly higher quantity of lymphocytes and their subpopulations (CD3+, CD4+, CD45RA+) as well as higher levels of IgM, IgG.

We conclude that vaccine Encepur Adult (Germany) possesses a high immunologic activity. It is recommended to use this vaccine as a safe and effective specific preventive remedy in TBE endemic areas.

About the Authors

G. N. Leonova
ГУ НИИ эпидемиологии и микробиологии СО РАМН, г. Владивосток
Russian Federation


N. V. Krylova
ГУ НИИ эпидемиологии и микробиологии СО РАМН, г. Владивосток
Russian Federation


E. V. Pavlenko
ГУ НИИ эпидемиологии и микробиологии СО РАМН, г. Владивосток
Russian Federation


O. S. Maystrovskaya
ГУ НИИ эпидемиологии и микробиологии СО РАМН, г. Владивосток
Russian Federation


References

1. Буковская С.Н., Воробьева М.С., Карпович Л.Г., Шаламберидзе Т.Д. Изучение некоторых количественных показателей иммунного статуса людей, привитых различными вакцинами против КЭ // Вопр. вирусол. -1983. -№4. -С.100-103.

2. Ворошилова М.К., Жевандрова В.И., Балаян М.С. Методы лабораторной диагностики энтеровирусных инфекций//М., 1964.

3. Костинов М.П. Ревматические заболевания//Вакцинопрофилактика при нарушении здоровья. М., 2001. -С.165-173.

4. Леонова Г.Н. Клещевой энцефалит в Приморском крае//Дальнаука, Владивосток. -1997.

5. Леонова Г.Н., Мизеров К.С., Крылова Н.В., Павленко Е.Н., Майстровская О.С., Борисова О.Н., Дитер Гниель. Клинико-иммунологическая эффективность вакцины "Энцепур" при вакцинации против клещевого энцефалита жителей Приморского края//Журн. "Биопрепараты" -2004. -№2 (14). -С.24-28.

6. Мазуров Д.В., Мастернак Ю.А., Пинегин Б.В. Возрастные изменения Т-лимфоцитов человека, несущих маркеры CD45RO и HLA-DR//Иммунология. -2002. -№5. -С.268-271.

7. Михайленко А.А., Базанов Г.А., Покровский В.И., Коненков В.И. Профилактическая иммунология. -М., 2004.

8. Найхин А.Н., Рекстин А.Р., Кац Дж. Пролиферативная активность лимфоцитов лиц пожилого возраста in vitro при раздельной и сочетанной иммунизации живой и инактивированной гриппозными вакцинами//Вопр. Вирусол. -2000. -№2. -С.41-45.

9. Digeon M., Laver M., Riza//J. Immunol. Meth. -1977. -16. -Р.165-183.

10. Eder G., Kollaritsch H. Antigenic dependent adverse reactions and serocoversion of a tick-borne encephalitis vaccine children//Vaccine. -2003. -Vol.21. -Р.3575-3583.

11. Gorse G.J., Belshe R.B. Enhanced lymphoproliferation to influenza A virus following vaccination of older, chronically ill adults with live attenuated viruses//Scand. J. infect. Dis. -1991. -Vol.23. -P.7-17.

12. Heinz F.X., Kunz C. Tick-borne encephalitis and the impact of vaccination//Archives of Virology. -2004. [Suppl]. -Vol.18. -Р.201-205.

13. Jiri Beran, Petr Dauda, Dieter Gniel, Olaf Zent Long-term immunity after vaccination against tick-borne encephalitis with Encepur® using rapid vaccination schedule//J.Med.Micobiol. -2004. -293, Suppl. -37.-Р.130-133.

14. Leonova G.N., Borisevich V.G, Pavlenko E.V., Kulakova N.V., Belikov S.I., D. Gniel. Tick-borne encephalitis in the Russian Far East//VII International Potsdam symposium on tick-borne diseases. Berlin (Germany), 13-14 March. -2003.

15. Manchini G., Carbonara A.O., Heremans J.E.//Immunochemistry. -1965. -Vol.2.-Р.235-254.

16. Schwab R., Russo C, Weksler M.E. Loss of MHC-restricted T-cell recognition of influenza antigens in aging//Aging Immunol. Infect. Dis. -1990.-Vol.2.-P.111-116.

17. Zent O., Jiri Beran, Wolfgang Jilg, Tomasz Mach, Angelika Banzhoff. Clinical evaluation of a polygeline-free encephalitis vaccine for adolescents and adults. Vaccine. -2003. -Vol.21. -P. 738-746.

18. Zent O., Banzhoff A., Hilbert A.K., Meriste S., Sluzewski W., Ch. Wittermann Safety, immunogenicity and tolerability of a new pediatric tick-borne encephalitis (TBE) vaccine, free of protein-derived stabilizer // Vaccine. -2003. -Vol.21. -Р. 3584-3592.


Review

For citations:


Leonova G.N., Krylova N.V., Pavlenko E.V., Maystrovskaya O.S. REACTOGENITY OF TICK-BORNE ENCEPHALITIS VACCINE ENCEPUR ADULT AND IMMUNE RESPONSE. Medical Immunology (Russia). 2005;7(4):391-396. (In Russ.) https://doi.org/10.15789/1563-0625-2005-4-391-396

Views: 1319


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 1563-0625 (Print)
ISSN 2313-741X (Online)