REACTOGENITY OF TICK-BORNE ENCEPHALITIS VACCINE ENCEPUR ADULT AND IMMUNE RESPONSE
https://doi.org/10.15789/1563-0625-2005-4-391-396
Abstract
Abstract. The comprehensive clinical-immunological characteristic of a tick-borne encephalitis vaccine En-cepur Adult (Germany), which was studied on a group of residents of Far East of Russia was discussed. Reactogenity in 32,4% of vaccinees was characterized by minor clinical manifestations and was due to the reaction to specific vaccine albumin. Expression of immune response (mean geometric titers) was evaluated in a neutralization test. A group with the reactogenity showed higher geometric mean antibody titers (1:182) compared with a group without the reactogenity (1:97).
All of vaccinees with various levels (high, middle, low) of specific immune response had an increased quantity of CD20+ and CD25+ lymphocytes. We showed a difference in immunologic reactivity of people with high and low levels of specific antibody response. As compared with a low level group the group with a high level of specific response showed significantly higher quantity of lymphocytes and their subpopulations (CD3+, CD4+, CD45RA+) as well as higher levels of IgM, IgG.
We conclude that vaccine Encepur Adult (Germany) possesses a high immunologic activity. It is recommended to use this vaccine as a safe and effective specific preventive remedy in TBE endemic areas.
About the Authors
G. N. LeonovaRussian Federation
N. V. Krylova
Russian Federation
E. V. Pavlenko
Russian Federation
O. S. Maystrovskaya
Russian Federation
References
1. Буковская С.Н., Воробьева М.С., Карпович Л.Г., Шаламберидзе Т.Д. Изучение некоторых количественных показателей иммунного статуса людей, привитых различными вакцинами против КЭ // Вопр. вирусол. -1983. -№4. -С.100-103.
2. Ворошилова М.К., Жевандрова В.И., Балаян М.С. Методы лабораторной диагностики энтеровирусных инфекций//М., 1964.
3. Костинов М.П. Ревматические заболевания//Вакцинопрофилактика при нарушении здоровья. М., 2001. -С.165-173.
4. Леонова Г.Н. Клещевой энцефалит в Приморском крае//Дальнаука, Владивосток. -1997.
5. Леонова Г.Н., Мизеров К.С., Крылова Н.В., Павленко Е.Н., Майстровская О.С., Борисова О.Н., Дитер Гниель. Клинико-иммунологическая эффективность вакцины "Энцепур" при вакцинации против клещевого энцефалита жителей Приморского края//Журн. "Биопрепараты" -2004. -№2 (14). -С.24-28.
6. Мазуров Д.В., Мастернак Ю.А., Пинегин Б.В. Возрастные изменения Т-лимфоцитов человека, несущих маркеры CD45RO и HLA-DR//Иммунология. -2002. -№5. -С.268-271.
7. Михайленко А.А., Базанов Г.А., Покровский В.И., Коненков В.И. Профилактическая иммунология. -М., 2004.
8. Найхин А.Н., Рекстин А.Р., Кац Дж. Пролиферативная активность лимфоцитов лиц пожилого возраста in vitro при раздельной и сочетанной иммунизации живой и инактивированной гриппозными вакцинами//Вопр. Вирусол. -2000. -№2. -С.41-45.
9. Digeon M., Laver M., Riza//J. Immunol. Meth. -1977. -16. -Р.165-183.
10. Eder G., Kollaritsch H. Antigenic dependent adverse reactions and serocoversion of a tick-borne encephalitis vaccine children//Vaccine. -2003. -Vol.21. -Р.3575-3583.
11. Gorse G.J., Belshe R.B. Enhanced lymphoproliferation to influenza A virus following vaccination of older, chronically ill adults with live attenuated viruses//Scand. J. infect. Dis. -1991. -Vol.23. -P.7-17.
12. Heinz F.X., Kunz C. Tick-borne encephalitis and the impact of vaccination//Archives of Virology. -2004. [Suppl]. -Vol.18. -Р.201-205.
13. Jiri Beran, Petr Dauda, Dieter Gniel, Olaf Zent Long-term immunity after vaccination against tick-borne encephalitis with Encepur® using rapid vaccination schedule//J.Med.Micobiol. -2004. -293, Suppl. -37.-Р.130-133.
14. Leonova G.N., Borisevich V.G, Pavlenko E.V., Kulakova N.V., Belikov S.I., D. Gniel. Tick-borne encephalitis in the Russian Far East//VII International Potsdam symposium on tick-borne diseases. Berlin (Germany), 13-14 March. -2003.
15. Manchini G., Carbonara A.O., Heremans J.E.//Immunochemistry. -1965. -Vol.2.-Р.235-254.
16. Schwab R., Russo C, Weksler M.E. Loss of MHC-restricted T-cell recognition of influenza antigens in aging//Aging Immunol. Infect. Dis. -1990.-Vol.2.-P.111-116.
17. Zent O., Jiri Beran, Wolfgang Jilg, Tomasz Mach, Angelika Banzhoff. Clinical evaluation of a polygeline-free encephalitis vaccine for adolescents and adults. Vaccine. -2003. -Vol.21. -P. 738-746.
18. Zent O., Banzhoff A., Hilbert A.K., Meriste S., Sluzewski W., Ch. Wittermann Safety, immunogenicity and tolerability of a new pediatric tick-borne encephalitis (TBE) vaccine, free of protein-derived stabilizer // Vaccine. -2003. -Vol.21. -Р. 3584-3592.
Review
For citations:
Leonova G.N., Krylova N.V., Pavlenko E.V., Maystrovskaya O.S. REACTOGENITY OF TICK-BORNE ENCEPHALITIS VACCINE ENCEPUR ADULT AND IMMUNE RESPONSE. Medical Immunology (Russia). 2005;7(4):391-396. (In Russ.) https://doi.org/10.15789/1563-0625-2005-4-391-396