FEATURES OF SPECIFIC IMMUNE RESPONSE IN THE PATIENTS WITH FIBROUS/CAVERNOUS TUBERCULOSIS OF LUNGS
https://doi.org/10.15789/1563-0625-2006-4-501-510
Abstract
Abstract. The aim of the present study was to determine the different profiles of the immune responsiveness of the patients with fibro-cavernous pulmonary tuberculosis to PPD from M.tuberculosis in comparison with their response to standart mitogen and IFNγ. A pronounced specific Th1 response was found, evidenced by the enhanced proliferation and IL-2 and IFNγ production after contact of their peripheral blood mononuclear cells (PBMCs) with PPD. At the same time a high frequency of PPD-anergy was shown: сonsiderable proportion of TB patients was characterized by low proliferative response to PPD coupled with the low levels of IL-2 and IFNγ. Most of the patients revealed failure of monocyte/macrophage oxidative burst in response to PPD. Additionally a positive correlation was found between the levels of their PBMC’s oxidative burst and IL-4 production.
About the Authors
T. E. Kissina
ГУ Научно-исследовательский институт экспериментальной медицины РАМН
Russian Federation
Russian Federation
I. S. Freidlin
ГУ Научно-исследовательский институт экспериментальной медицины РАМН
Russian Federation
Russian Federation
B. E. Knoring
ФГУ НИИ Фтизиопульмонологии Росздрава
Russian Federation
Russian Federation
T. S. Basek
ФГУ НИИ Фтизиопульмонологии Росздрава
Russian Federation
Russian Federation
A. B. Elkin
ФГУ НИИ Фтизиопульмонологии Росздрава
Russian Federation
Russian Federation
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Review
For citations:
Kissina T.E., Freidlin I.S., Knoring B.E., Basek T.S., Elkin A.B. FEATURES OF SPECIFIC IMMUNE RESPONSE IN THE PATIENTS WITH FIBROUS/CAVERNOUS TUBERCULOSIS OF LUNGS. Medical Immunology (Russia). 2006;8(4):501-510. (In Russ.) https://doi.org/10.15789/1563-0625-2006-4-501-510
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