mimmunМедицинская иммунологияMedical Immunology (Russia)1563-06252313-741XSPb RAACI10.15789/1563-0625-2006-4-501-510mimmun-462Research ArticleОРИГИНАЛЬНЫЕ СТАТЬИORIGINAL ARTICLESОСОБЕННОСТИ СПЕЦИФИЧЕСКОГО ИММУННОГО ОТВЕТА У ОТДЕЛЬНЫХ БОЛЬНЫХ ФИБРОЗНО4КАВЕРНОЗНЫМ ТУБЕРКУЛЕЗОМ ЛЕГКИХFEATURES OF SPECIFIC IMMUNE RESPONSE IN THE PATIENTS WITH FIBROUS/CAVERNOUS TUBERCULOSIS OF LUNGSКисинаТ. Е.KissinaT. E.

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tkissina@yandex.ruФрейдлинИ. С.FreidlinI. S.tkissina@yandex.ruКнорингБ. Е.KnoringB. E.tkissina@yandex.ruБасекТ. С.BasekT. S.tkissina@yandex.ruЕлькинА. В.ElkinA. B.tkissina@yandex.ruГУ Научно-исследовательский институт экспериментальной медицины РАМНRussian FederationФГУ НИИ Фтизиопульмонологии РосздраваRussian Federation20062107201484501510Copyright © Кисина Т.Е., Фрейдлин И.С., Кноринг Б.Е., Басек Т.С., Елькин А.В., 20142014Кисина Т.Е., Фрейдлин И.С., Кноринг Б.Е., Басек Т.С., Елькин А.В.Kissina T.E., Freidlin I.S., Knoring B.E., Basek T.S., Elkin A.B.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.mimmun.ru/mimmun/article/view/462

Резюме. Работа посвящена изучению различных проявлений ответа мононуклеаров крови больных фиброзно-кавернозным туберкулезом (ФКТ) легких на контакт со специфическими антигенами в составе туберкулина, в сопоставлении с ответом тех же клеток на стандартные митогены и на цитокин IFNγ. У больных туберкулезом обнаружены проявления выраженного клеточного специфического иммунного ответа, судя по повышенной пролиферации лимфоцитов крови в ответ на PPD и усиленной секреции этими клетками IL-2 и IFNγ в ответ на PPD. Вместе с тем показана высокая частота PPD-анергии среди больных ФКТ: выявлена подгруппа с низкой пролиферацией на PPD в сочетании со сниженными уровнями секреции IL-2 и IFNγ. У значительной части больных выявлен дефект ответа моноцитов/макрофагов окислительным взрывом на PPD. При этом показана корреляция выраженности окислительного взрыва мононуклеаров больных с уровнями продукции теми же клетками IL-4.

Abstract. The aim of the present study was to determine the different profiles of the immune responsiveness of the patients with fibro-cavernous pulmonary tuberculosis to PPD from M.tuberculosis in comparison with their response to standart mitogen and IFNγ. A pronounced specific Th1 response was found, evidenced by the enhanced proliferation and IL-2 and IFNγ production after contact of their peripheral blood mononuclear cells (PBMCs) with PPD. At the same time a high frequency of PPD-anergy was shown: сonsiderable proportion of TB patients was characterized by low proliferative response to PPD coupled with the low levels of IL-2 and IFNγ. Most of the patients revealed failure of monocyte/macrophage oxidative burst in response to PPD. Additionally a positive correlation was found between the levels of their PBMC’s oxidative burst and IL-4 production.

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The authors declare that there are no conflicts of interest present.