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ФУНДАМЕНТАЛЬНАЯ ИММУНОБИОЛОГИЯ ПРОВОСПАЛИТЕЛЬНЫХ ЦИТОКИНОВ И MIF

https://doi.org/10.15789/1563-0625-2006-1-5-22

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Аннотация

Резюме. Сравнение цитокинов и MIF по основным общебиологическим свойствам показывает наличие, как сходства, так и существенных различий. Особенностями MIF являются уникальность его структуры, повсеместная распространенность в органах и тканях организма, исключительно широкое разнообразие функций (провоспалительный цитокин, фермент, гормон), способность индуцироваться глюкокортикои дами и оказывать контррегулирующее действие на их иммуносупрессивные эффекты. MIF находится в преформированном состоянии в лимфоцитах, макрофагах и клетках эндотелия. Он выделяется этими клетками и функционирует как фактор мобилизации защитной системы уже в первые минуты чужеродного воздействия. MIF проявляет свойства суперлиганда, связываясь со множеством биологически важных молекул, Этот фактор осуществляет функции, важные для активации клетки, ее размножения и гибели, используя разнообразные внутриклеточные сигнальные пути. В эволюции гомологи MIF обнаруживают уже у растений и бактерий, то есть до появления адоптивной и врожденной иммунной системы. В онтогенезе MIF появляется уже на стадии первых клеточных делений. Широта функций MIF многообразие его лига дных связей, разнообразие путей реализации функций, повсеместное распространения в организме, раннее появление в онтогенезе и филогенезе, а также в ходе защитной реакции клетки и организма в целом – все эти факторы вместе взятые позволяют позиционировать MIF как особый тип цитокина – эоцитокин (от греческого эо – ранний). Предполагается, что MIF может функционировать как ключевой фактор «естественной устойчивости» клетки и организма.

Об авторах

А. П. Суслов
ГУ НИИЭМ им.Н.Ф.Гамалеи РАМН, Москва
Россия

лаборатория эффекторов и медиаторов воспаления

123098, ул.Гамалеи, д.18. Тел.: (495)193‑61‑31, факс (495) 193‑43‑50



М. В. Коноплева
ГУ НИИЭМ им.Н.Ф.Гамалеи РАМН, Москва
Россия

лаборатория эффекторов и медиаторов воспаления



О. Ю. Третьяков
ГУ НИИЭМ им.Н.Ф.Гамалеи РАМН, Москва
Россия

лаборатория эффекторов и медиаторов воспаления



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Для цитирования:


Суслов А.П., Коноплева М.В., Третьяков О.Ю. ФУНДАМЕНТАЛЬНАЯ ИММУНОБИОЛОГИЯ ПРОВОСПАЛИТЕЛЬНЫХ ЦИТОКИНОВ И MIF. Медицинская иммунология. 2006;8(1):5-22. https://doi.org/10.15789/1563-0625-2006-1-5-22

For citation:


Suslov A.P., Konopleva M.V., Tretiakov O.Yu. FUNDAMENTAL IMMUNOBIOLOGY OF PRO-INFLAMMATORY CYTOKINES AND MIF. Medical Immunology (Russia). 2006;8(1):5-22. (In Russ.) https://doi.org/10.15789/1563-0625-2006-1-5-22

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