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CLINICAL AND IMMUNOLOGICAL ASPECTS OF T C ELL-BASED VACCINE THERAPY IN PATIENTS WITH PROGREDIENT MULTIPLE SCLEROSIS

https://doi.org/10.15789/1563-0625-2012-1-2-103-108

Abstract

Abstract. Thirty-nine patients with a progredient clinical form of chronic multiple sclerosis (MS) were subject to multiple immunization with autologous polyclonal T-cell vaccines. Two years after initiating the vaccine therapy, no evidence for disease progression was noted in 16 patients (41% of total). Neurological improvement was observed in five cases (13%) from the vaccine-treated group. Of 22 control MS patients who did not receive the immunotherapy, only 6 persons (27%) exhibited stabilization of their clinical state. Clinical improvement was not detectable among this group of MS patients. A group of twenty-six MS patients was treated with Rebif, without evidence of disease progression in eleven cases (42%), and distinct neurological improvement noted in one patient (4%) from this group. One year after starting the vaccine therapy, a rise in serum IL-10 was detected in vaccine-treated patients, whereas IL-17 and IL-18 serum levels remained within the initial ranges. A correlation between the serum levels of anti-myelin antibodies and appropriate anti-idiotypic antibodies was revealed in these patients. In general, the results obtained suggest polyclonal T-cell vaccination as a potentially effective treatment approach, both at early and more advanced stages of the disorder.

About the Authors

G. Seledtsova
НИИ клинической иммунологии CО РАМН, г. Новосибирск
Russian Federation


I. Ivanova
НИИ клинической иммунологии CО РАМН, г. Новосибирск
Russian Federation


S. Mamaev
Клиническая больница № 85, Москва
Russian Federation


D. Seledtsov
НИИ клинической иммунологии CО РАМН, г. Новосибирск
Russian Federation


N. Malkova
Областной центр рассеянного склероза, г. Новосибирск
Russian Federation


V. Seledtsov
Балтийский федеральный университет им. И. Канта, г. Калининград
Russian Federation


V. I. Seledtsov
Балтийский федеральный университет им. И. Канта, г. Калининград


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Review

For citations:


Seledtsova G., Ivanova I., Mamaev S., Seledtsov D., Malkova N., Seledtsov V., Seledtsov V.I. CLINICAL AND IMMUNOLOGICAL ASPECTS OF T C ELL-BASED VACCINE THERAPY IN PATIENTS WITH PROGREDIENT MULTIPLE SCLEROSIS. Medical Immunology (Russia). 2012;14(1-2):103-108. (In Russ.) https://doi.org/10.15789/1563-0625-2012-1-2-103-108

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ISSN 1563-0625 (Print)
ISSN 2313-741X (Online)