<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">mimmun</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинская иммунология</journal-title><trans-title-group xml:lang="en"><trans-title>Medical Immunology (Russia)</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1563-0625</issn><issn pub-type="epub">2313-741X</issn><publisher><publisher-name>SPb RAACI</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.15789/1563-0625-2012-1-2-103-108</article-id><article-id custom-type="elpub" pub-id-type="custom">mimmun-303</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ СТАТЬИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL ARTICLES</subject></subj-group></article-categories><title-group><article-title>КЛИНИЧЕСКИЕ И ИММУНОЛОГИЧЕСКИЕ АСПЕКТЫ Т-КЛЕТОЧНОЙ ВАКЦИНОТЕРАПИИ У БОЛЬНЫХ ПРОГРЕДИЕНТНОЙ ФОРМОЙ РАССЕЯННОГО СКЛЕРОЗА</article-title><trans-title-group xml:lang="en"><trans-title>CLINICAL AND IMMUNOLOGICAL ASPECTS OF T C ELL-BASED VACCINE THERAPY IN PATIENTS WITH PROGREDIENT MULTIPLE SCLEROSIS</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Селедцова</surname><given-names>Г. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Seledtsova</surname><given-names>G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>630099, г. Новосибирск, ул. Ядринцевская, 14. Тел.: (383) 236-06-40. Факс: (383) 228-26-73.</p></bio><email xlink:type="simple">galina-seledtsova@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Иванова</surname><given-names>И. П.</given-names></name><name name-style="western" xml:lang="en"><surname>Ivanova</surname><given-names>I.</given-names></name></name-alternatives><email xlink:type="simple">galina-seledtsova@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мамаев</surname><given-names>С. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Mamaev</surname><given-names>S.</given-names></name></name-alternatives><email xlink:type="simple">galina-seledtsova@yandex.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Селедцов</surname><given-names>Д. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Seledtsov</surname><given-names>D.</given-names></name></name-alternatives><email xlink:type="simple">galina-seledtsova@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Малкова</surname><given-names>Н. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Malkova</surname><given-names>N.</given-names></name></name-alternatives><email xlink:type="simple">galina-seledtsova@yandex.ru</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Литвинова</surname><given-names>Л. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Seledtsov</surname><given-names>V.</given-names></name></name-alternatives><email xlink:type="simple">galina-seledtsova@yandex.ru</email><xref ref-type="aff" rid="aff-4"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Селедцов</surname><given-names>В. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Seledtsov</surname><given-names>V. I.</given-names></name></name-alternatives><email xlink:type="simple">galina-seledtsova@yandex.ru</email><xref ref-type="aff" rid="aff-4"/></contrib></contrib-group><aff xml:lang="ru" id="aff-1"><institution>НИИ клинической иммунологии CО РАМН, г. Новосибирск</institution><country>Russian Federation</country></aff><aff xml:lang="ru" id="aff-2"><institution>Клиническая больница № 85, Москва</institution><country>Russian Federation</country></aff><aff xml:lang="ru" id="aff-3"><institution>Областной центр рассеянного склероза, г. Новосибирск</institution><country>Russian Federation</country></aff><aff xml:lang="ru" id="aff-4"><institution>Балтийский федеральный университет им. И. Канта, г. Калининград</institution><country>Russian Federation</country></aff><pub-date pub-type="collection"><year>2012</year></pub-date><pub-date pub-type="epub"><day>19</day><month>07</month><year>2014</year></pub-date><volume>14</volume><issue>1-2</issue><fpage>103</fpage><lpage>108</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Селедцова Г.В., Иванова И.П., Мамаев С.В., Селедцов Д.В., Малкова Н.А., Литвинова Л.С., Селедцов В.И., 2014</copyright-statement><copyright-year>2014</copyright-year><copyright-holder xml:lang="ru">Селедцова Г.В., Иванова И.П., Мамаев С.В., Селедцов Д.В., Малкова Н.А., Литвинова Л.С., Селедцов В.И.</copyright-holder><copyright-holder xml:lang="en">Seledtsova G., Ivanova I., Mamaev S., Seledtsov D., Malkova N., Seledtsov V., Seledtsov V.I.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.mimmun.ru/mimmun/article/view/303">https://www.mimmun.ru/mimmun/article/view/303</self-uri><abstract/><trans-abstract xml:lang="en"/><kwd-group xml:lang="ru"><kwd>Т-клеточная вакцинотерапия</kwd><kwd>рассеянный склероз</kwd><kwd>цитокины</kwd><kwd>антимиелиновые антитела</kwd><kwd>антиидиотипические антитела</kwd></kwd-group><kwd-group xml:lang="en"><kwd>Т-cell vaccination</kwd><kwd>multiple sclerosis</kwd><kwd>cytokines</kwd><kwd>antimyelin antibodies</kwd><kwd>anti-idiotypic antibodies</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Иванова И.П.. Селедцов В.И., Банул Н.В., Самарин Д.М., Селедцова Г.В., Савкин И.В., Ширинский В.С., Пронкина Н.В., Козлов В.А. Получение Т-клеточной вакцины и ее применение для лечения рассеянного склероза // Мед. Иммунология. – 2005. – Т. 7, № 1. – С. 27-32.</mixed-citation><mixed-citation xml:lang="en">Иванова И.П.. Селедцов В.И., Банул Н.В., Самарин Д.М., Селедцова Г.В., Савкин И.В., Ширинский В.С., Пронкина Н.В., Козлов В.А. Получение Т-клеточной вакцины и ее применение для лечения рассеянного склероза // Мед. Иммунология. – 2005. – Т. 7, № 1. – С. 27-32.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Иванова И.П., Селедцов В.И., Селедцова Г.В., Мамаев С.В., Потемкин А.В., Селедцов Д.В., Козлов В.А. Индукция антиидиотипического иммунного ответа аутологичной Т-клеточной вакциной у больных рассеянным склерозом // Клеточные технологии в биологии и медицине. – 2008. – № 3. – С. 145-149.</mixed-citation><mixed-citation xml:lang="en">Иванова И.П., Селедцов В.И., Селедцова Г.В., Мамаев С.В., Потемкин А.В., Селедцов Д.В., Козлов В.А. Индукция антиидиотипического иммунного ответа аутологичной Т-клеточной вакциной у больных рассеянным склерозом // Клеточные технологии в биологии и медицине. – 2008. – № 3. – С. 145-149.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Stinissen P., Zhang J., Vandevyver C., Hermans G., Raus J. Gammadelta T cell responses to activated T cells in multiple sclerosis patients induced by T cell vaccination // J. Neuroimmunol. – 1998. – N 87. – P. 94-104.</mixed-citation><mixed-citation xml:lang="en">Stinissen P., Zhang J., Vandevyver C., Hermans G., Raus J. Gammadelta T cell responses to activated T cells in multiple sclerosis patients induced by T cell vaccination // J. Neuroimmunol. – 1998. – N 87. – P. 94-104.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Giuliani F., Yong V. Immune-mediated neurodegeneration and neuroprotection in MS // Int. MS J. – 2003. – N 10. – P. 122-130.</mixed-citation><mixed-citation xml:lang="en">Giuliani F., Yong V. Immune-mediated neurodegeneration and neuroprotection in MS // Int. MS J. – 2003. – N 10. – P. 122-130.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Giuliani F., Goodyer C., Antel J., Yong V. Vulnerability of human neurons to T cell-mediated cytotoxicity // J. Immunol. – 2003. – N. 171. – P. 368-379.</mixed-citation><mixed-citation xml:lang="en">Giuliani F., Goodyer C., Antel J., Yong V. Vulnerability of human neurons to T cell-mediated cytotoxicity // J. Immunol. – 2003. – N. 171. – P. 368-379.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Okun E., Mattson M., Arumugam T. Involvement of Fc receptors in disorders of the central nervous system // Neuromolecular Med. – 2010. – N 12 (2). – Р. 164-178.</mixed-citation><mixed-citation xml:lang="en">Okun E., Mattson M., Arumugam T. Involvement of Fc receptors in disorders of the central nervous system // Neuromolecular Med. – 2010. – N 12 (2). – Р. 164-178.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Correale J., Lund B., McMillan M., Ko D., McCarthy K., Weiner L. T cell vaccination in secondary progressive multiple sclerosis // J. Neuroimmunol. – 2000. – N 107. – P. 130-139.</mixed-citation><mixed-citation xml:lang="en">Correale J., Lund B., McMillan M., Ko D., McCarthy K., Weiner L. T cell vaccination in secondary progressive multiple sclerosis // J. Neuroimmunol. – 2000. – N 107. – P. 130-139.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Correale J., Farez M., Gilmore W. Vaccines for Multiple Sclerosis : Progress to Date // CNS Drugs. – 2008. – N 22. – P. 175-198.</mixed-citation><mixed-citation xml:lang="en">Correale J., Farez M., Gilmore W. Vaccines for Multiple Sclerosis : Progress to Date // CNS Drugs. – 2008. – N 22. – P. 175-198.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Orduno N., Quach T., Sanz1 I. B cells and immunological tolerance // J. Invest. Dermatol. – 2009. – Vol. 129 (2). – P. 278-288.</mixed-citation><mixed-citation xml:lang="en">Orduno N., Quach T., Sanz1 I. B cells and immunological tolerance // J. Invest. Dermatol. – 2009. – Vol. 129 (2). – P. 278-288.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Gutcher I., Urich E., Wolter K., Prinz M., Becher B. Interleukin 18-independent engagement of interleukin 18 receptor-alpha is required for autoimmune inflammation // Nat. Immunol. – 2006. – N 7. – P. 946-953.</mixed-citation><mixed-citation xml:lang="en">Gutcher I., Urich E., Wolter K., Prinz M., Becher B. Interleukin 18-independent engagement of interleukin 18 receptor-alpha is required for autoimmune inflammation // Nat. Immunol. – 2006. – N 7. – P. 946-953.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Nicoletti F., Di Marco R., Mangano K., Patti F., Reggio E., Nicoletti A., Bendtzen K., Reggio A. Increased serum levels of interleukin-18 in patients with multiple sclerosis // Neurology. – 2001. – N 57 (2). – P. 342-344.</mixed-citation><mixed-citation xml:lang="en">Nicoletti F., Di Marco R., Mangano K., Patti F., Reggio E., Nicoletti A., Bendtzen K., Reggio A. Increased serum levels of interleukin-18 in patients with multiple sclerosis // Neurology. – 2001. – N 57 (2). – P. 342-344.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Huang W.X., Huang P., Hillert J. Increased expression of caspase-1 and interleukin-18 in peripheral blood mononuclear cells in patients with multiple sclerosis // Multiple Sclerosis Jornal. – 2004. – N 10. – P. 482-487.</mixed-citation><mixed-citation xml:lang="en">Huang W.X., Huang P., Hillert J. Increased expression of caspase-1 and interleukin-18 in peripheral blood mononuclear cells in patients with multiple sclerosis // Multiple Sclerosis Jornal. – 2004. – N 10. – P. 482-487.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Gutcher I., Becher B. APC-derived cytokines and T cell polarization in autoimmune inflammation // J. Clin. Invest. – 2007. – Vol. 117. – P. 1119-1127.</mixed-citation><mixed-citation xml:lang="en">Gutcher I., Becher B. APC-derived cytokines and T cell polarization in autoimmune inflammation // J. Clin. Invest. – 2007. – Vol. 117. – P. 1119-1127.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
