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Медицинская иммунология

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ГАЛЕКТИН-1: РОЛЬ В ФОРМИРОВАНИИ ОСОБЕННОСТЕЙ ВРОЖДЕННОГО И ПРИОБРЕТЕННОГО ИММУНИТЕТА

https://doi.org/10.15789/1563-0625-2012-1-2-21-32

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Аннотация

Резюме. Галектины – это β-галактозид-связывающие белки, объединенные в одно семейство согласно гомологии их углевод-распознающего домена. Данные лектины связываются с гликанами клеточной поверхности и экстрацеллюлярного матрикса, оказывая, таким образом, влияние на клеточный цикл, адгезию, миграцию, пролиферацию и апоптоз. Кроме того, галектины способны действовать внутриклеточно и принимать участие, например, в сигнальной трансдукции, взаимодействуя с другими белками цитоплазмы и ядра. В регуляции функциональной активности клеток иммунной системы особое значение отводится галектину-1. Данный белок, являясь фактором кооперации иммунокомпетентных клеток, способен модулировать иммунные реакции. В связи с этим, галектин-1 рассматривается в качестве возможного агента или мишени для разработки новых методов коррекции патологических процессов, связанных с дисбалансом клеток иммунной системы. В данной статье приводится обзор работ посвященных изучению роли галектина-1 в формировании особенностей врожденного и приобретенного иммунитета.

Об авторах

В. Д. Якушина
ГБОУ ВПО Сибирский государственный медицинский университет Минздравсоцразвития России, г. Томск
Россия


О. А. Васильева
ГБОУ ВПО Сибирский государственный медицинский университет Минздравсоцразвития России, г. Томск
Россия
634057, г. Томск, ул. Говорова, 11-б, кв. 26. Тел.: (3822) 47-33-57


Н. В. Рязанцева
ГБОУ ВПО Сибирский государственный медицинский университет Минздравсоцразвития России, г. Томск
Россия


В. В. Новицкий
ГБОУ ВПО Сибирский государственный медицинский университет Минздравсоцразвития России, г. Томск
Россия


О. Е. Савельева
ГБОУ ВПО Сибирский государственный медицинский университет Минздравсоцразвития России, г. Томск
Россия


Т. С. Прохоренко
ГБОУ ВПО Сибирский государственный медицинский университет Минздравсоцразвития России, г. Томск
Россия


Е. Г. Старикова
ГБОУ ВПО Сибирский государственный медицинский университет Минздравсоцразвития России, г. Томск
Россия


А. П. Зима
ГБОУ ВПО Сибирский государственный медицинский университет Минздравсоцразвития России, г. Томск
Россия


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Для цитирования:


Якушина В.Д., Васильева О.А., Рязанцева Н.В., Новицкий В.В., Савельева О.Е., Прохоренко Т.С., Старикова Е.Г., Зима А.П. ГАЛЕКТИН-1: РОЛЬ В ФОРМИРОВАНИИ ОСОБЕННОСТЕЙ ВРОЖДЕННОГО И ПРИОБРЕТЕННОГО ИММУНИТЕТА. Медицинская иммунология. 2012;14(1-2):21-32. https://doi.org/10.15789/1563-0625-2012-1-2-21-32

For citation:


Yakushina V.D., Vasilyeva O.A., Ryazantseva N.V., Novitsky V.V., Savelyeva O.E., Prokhorenko T.S., Starikova E.G., Zima A.P. GALECTIN-1 AND ITS ROLE IN DEVELOPMENT OF INNATE AND ADAPTIVE IMMUNITY. Medical Immunology (Russia). 2012;14(1-2):21-32. (In Russ.) https://doi.org/10.15789/1563-0625-2012-1-2-21-32

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