mimmunМедицинская иммунологияMedical Immunology (Russia)1563-06252313-741XSPb RAACI10.15789/1563-0625-2012-1-2-21-32mimmun-288Research ArticleОБЗОРЫREVIEWSГАЛЕКТИН-1: РОЛЬ В ФОРМИРОВАНИИ ОСОБЕННОСТЕЙ ВРОЖДЕННОГО И ПРИОБРЕТЕННОГО ИММУНИТЕТАGALECTIN-1 AND ITS ROLE IN DEVELOPMENT OF INNATE AND ADAPTIVE IMMUNITYЯкушинаВ. Д.YakushinaV. D.vasiljeva-24@yandex.ruВасильеваО. А.VasilyevaO. A.

634057, г. Томск, ул. Говорова, 11-б, кв. 26. Тел.: (3822) 47-33-57

vasiljeva-24@yandex.ruРязанцеваН. В.RyazantsevaN. V.vasiljeva-24@yandex.ruНовицкийВ. В.NovitskyV. V.vasiljeva-24@yandex.ruСавельеваО. Е.SavelyevaO. E.vasiljeva-24@yandex.ruПрохоренкоТ. С.ProkhorenkoT. S.vasiljeva-24@yandex.ruСтариковаЕ. Г.StarikovaE. G.vasiljeva-24@yandex.ruЗимаА. П.ZimaA. P.vasiljeva-24@yandex.ruГБОУ ВПО Сибирский государственный медицинский университет Минздравсоцразвития России, г. ТомскRussian Federation201219072014141-22132Copyright © Якушина В.Д., Васильева О.А., Рязанцева Н.В., Новицкий В.В., Савельева О.Е., Прохоренко Т.С., Старикова Е.Г., Зима А.П., 20142014Якушина В.Д., Васильева О.А., Рязанцева Н.В., Новицкий В.В., Савельева О.Е., Прохоренко Т.С., Старикова Е.Г., Зима А.П.Yakushina V.D., Vasilyeva O.A., Ryazantseva N.V., Novitsky V.V., Savelyeva O.E., Prokhorenko T.S., Starikova E.G., Zima A.P.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.mimmun.ru/mimmun/article/view/288

Резюме. Галектины – это β-галактозид-связывающие белки, объединенные в одно семейство согласно гомологии их углевод-распознающего домена. Данные лектины связываются с гликанами клеточной поверхности и экстрацеллюлярного матрикса, оказывая, таким образом, влияние на клеточный цикл, адгезию, миграцию, пролиферацию и апоптоз. Кроме того, галектины способны действовать внутриклеточно и принимать участие, например, в сигнальной трансдукции, взаимодействуя с другими белками цитоплазмы и ядра. В регуляции функциональной активности клеток иммунной системы особое значение отводится галектину-1. Данный белок, являясь фактором кооперации иммунокомпетентных клеток, способен модулировать иммунные реакции. В связи с этим, галектин-1 рассматривается в качестве возможного агента или мишени для разработки новых методов коррекции патологических процессов, связанных с дисбалансом клеток иммунной системы. В данной статье приводится обзор работ посвященных изучению роли галектина-1 в формировании особенностей врожденного и приобретенного иммунитета.

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The authors declare that there are no conflicts of interest present.