FUNCTIONAL ACTIVITY OF NEUTROPHILS IN CHRONIC RECURRENT FURUNCULOSIS
https://doi.org/10.15789/1563-0625-2014-1-81-88
Abstract
Functional characteristics of neutrophils were evaluated in fifty-two patients with severe form of
chronic recurrent furunculosis, i.e., intensity of oxygen- and nitric oxide production, apoptosis rates, NET-
forming properties, as well as phagocytic and bactericidal capacity. We have detected reduced efficiency of
intracellular pathogen killing, accompanied by a suppression of oxygen- and nitric oxide-producing reserve of
neutrophils. A compensatory increase in functional reserve of NET formation activity was also revealed, thus
being a potential extracellular bactericidal mechanism for neutrophils. At the time of the disease exacerbation,
we have found a decreased readiness for both spontaneous and stimulated neutrophil apoptosis.
About the Authors
I. A. Novikovа
State Medical University, Gomel
Belarus
Belarus
PhD, MD (Medicine), Professor, Chief, Department of Clinical Laboratory Diagnostics, Allergy and Immunology
N, V. Gusakova
State Medical University, Gomel
Belarus
Belarus
Postgraduate Student, Department of Clinical Laboratory Diagnostics, Allergy and Immunology
A. V. Hamaliaka
State Medical University, Gomel
Belarus
Belarus
PhD (Medicine), Assistant Professor, Department of Clinical Laboratory Diagnostics, Allergy and Immunology
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Review
For citations:
Novikovа I.A., Gusakova N.V., Hamaliaka A.V. FUNCTIONAL ACTIVITY OF NEUTROPHILS IN CHRONIC RECURRENT FURUNCULOSIS. Medical Immunology (Russia). 2014;16(1):81-88. (In Russ.) https://doi.org/10.15789/1563-0625-2014-1-81-88
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