ROLE OF MACROPHAGES IN REGULATION OF HEMATOPOIETIC STEM CELL MIGRATION IN BONE MARROW PERIPHERAL BLOOD SYSTEM
https://doi.org/10.15789/1563-0625-2010-1-2-7-12
Abstract
Mechanisms by which HSCs mobilize into damaged organs are currently under scrutiny.
Macrophage role in these processes is investigated. In this study, we performed a flow cytometry analysis of
CD117+CD38+ and CD117+CD90low HSCs quantity in murine peripheral blood and bone marrow after liver
and kidney injury under stimulation of phagocyte mononuclear system by injection of tamerit. This study have
demonstrated increased levels of CD117+CD38+ HSCs in bone marrow after partial hepatectomy, along with
their migration to peripheral blood in response to tamerit injection. We also demonstrated that peripheral
blood CD117+CD38+ HSCs levels were elevated after kidney injury. After partial hepatectomy, nochanges
of CD117+CD90low HSCs quantity in investigated tissues were detected. We observed increased number of
CD117+CD90low HSCs in murine blood following kidney injury. Thus, we observed different influence of
macrophage stimulation on the quantity of CD117+CD38+ and CD117+CD90low cells. These data suggest
that HSCs mobilization from the bone marrow to peripheral blood depends, at least in part, on phagocyte
mononuclear system, and that macrophage stimulation is important for proliferation and migration of various
HSCs populations following liver and kidney injury.
About the Authors
B. G. Yushkov
Институт иммунологии и физиологии УрО РАН, г. Екатеринбург
Russian Federation
Russian Federation
I. G. Danilova
Институт иммунологии и физиологии УрО РАН, г. Екатеринбург
Russian Federation
Russian Federation
I. A. Pashnina
Институт иммунологии и физиологии УрО РАН, г. Екатеринбург
Russian Federation
Russian Federation
I. A. Brykina
Институт иммунологии и физиологии УрО РАН, г. Екатеринбург
Russian Federation
Russian Federation
M. T. Abidov
Институт иммунопатологии, Москва
Russian Federation
Russian Federation
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Review
For citations:
Yushkov B.G., Danilova I.G., Pashnina I.A., Brykina I.A., Abidov M.T. ROLE OF MACROPHAGES IN REGULATION OF HEMATOPOIETIC STEM CELL MIGRATION IN BONE MARROW PERIPHERAL BLOOD SYSTEM. Medical Immunology (Russia). 2010;12(1-2):7-12. (In Russ.) https://doi.org/10.15789/1563-0625-2010-1-2-7-12
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