ANALYSIS OF CONTROL MEASUREMENTS OF «T-CELL REPLICATES» AND «T-CELL SUMMARY» IN INVESTIGATION OF THE IMMUNE STATUS OF HIV-INFECTED PATIENTS AND DETECTION DOUBLE NEGATIVE SUBPOPULATION OF T-LYMPHOCYTES (CD45+CD3+CD4–CD8–)
https://doi.org/10.15789/1563-0625-2008-4-5-463-466
Abstract
Abstract. We analyzed efficiency of application for analytic control parameters, i.e., «T-cell replicates» and «T-cell summary» in a sample of 174 HIV-infected patients, independently of age or disease stage. The patients were divided in two groups. Group 1 consisted of patients with total CD45+CD3+CD4+ and CD45+CD3+CD8+ lymphocyte concentrations being similar to relative and absolute concentrations of CD45+CD3+ lymphocytes, or the difference between absolute measurements not exceeding «T-cell replicates» differences. Group 1 included 36.78% of the whole cohort. Group 2 consisted of patients with total CD45+CD3+CD4+ & CD45+CD3+CD8+ lymphocytes concentrations being lower than relative and absolute concentrations of CD45+CD3+ lymphocytes, and the differences in absolute values being higher than «T-cell replicates» differences (41.38% of total sample). Such difference between control sums may be connected with high concentrations of double-negative γδ-T-cells (CD45+CD3+CD4–CD8–) in the specimens under study. (Med. Immunol., 2008, vol. 10, N 4-5, pp 463-466).
About the Authors
E. V. Shestakova
Клиника ГОУ ВПО Челябинской государственной медицинской академии, г. Челябинск
Russian Federation
Russian Federation
A. V. Zurochka
ГОУ ВПО Челябинская государственная медицинская академия, г. Челябинск
Russian Federation
Russian Federation
S. V. Kviatkovskaya
Клиника ГОУ ВПО Челябинской государственной медицинской академии, г. Челябинск
Russian Federation
Russian Federation
S. G. Betskov
Клиника ГОУ ВПО Челябинской государственной медицинской академии, г. Челябинск
Russian Federation
Russian Federation
V. V. Dukardt
Клиника ГОУ ВПО Челябинской государственной медицинской академии, г. Челябинск
Russian Federation
Russian Federation
S. V. Haidukov
Институт биоорганической химии им. акад. М.М. Шемякина и Ю.А. Овчинникова РАН, Москва
Russian Federation
Russian Federation
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Review
For citations:
Shestakova E.V., Zurochka A.V., Kviatkovskaya S.V., Betskov S.G., Dukardt V.V., Haidukov S.V. ANALYSIS OF CONTROL MEASUREMENTS OF «T-CELL REPLICATES» AND «T-CELL SUMMARY» IN INVESTIGATION OF THE IMMUNE STATUS OF HIV-INFECTED PATIENTS AND DETECTION DOUBLE NEGATIVE SUBPOPULATION OF T-LYMPHOCYTES (CD45+CD3+CD4–CD8–). Medical Immunology (Russia). 2008;10(4-5):463-466. (In Russ.) https://doi.org/10.15789/1563-0625-2008-4-5-463-466
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