АNALYSIS OF THE EXPRESSION LEVEL OF T-CELL GENES AND OXIDATIVE PROCESSES IN STROKE

H. V. Zanginyan; L. M. Hovsepyan; G. S. Kazaryan; G. V. Zakaryan

doi:10.15789/1563-0625-2019-2-251-256

АNALYSIS OF THE EXPRESSION LEVEL OF T-CELL GENES AND OXIDATIVE PROCESSES IN STROKE

H. V. Zanginyan, L. M. Hovsepyan, G. S. Kazaryan, G. V. Zakaryan

https://doi.org/10.15789/1563-0625-2019-2-251-256

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Abstract

The level of expression of genes of transcription factors (GATA-3, TBX21, IL-2PG), and changing of oxidative processes in ischemic stroke were studied.

It was found that activation of Th2 cells (increase in the expression of transcription factor GATA-3) is observed in stroke, and suppression of Th1 cells (a decrease in the expression of IL-2 and its receptors, as well as the TBX21 gene). Increasing the expression of transcription factor GATA-3 in stroke patients underlies the increase in production in these patients of Th2-cytokines.

A comparative analysis of protein oxidation in blood plasma revealed an increase in the intensity of oxidative modification of proteins in stroke patients.

Investigation of glutathione content, activity of glutathione peroxidase enzymes, glutathione reductase in erythrocytes in stroke revealed a decrease in the content of glutathione and glutathione reductase and an increase in the activity of glutathione peroxidase.

The findings may be useful for a better understanding of the mechanisms of stroke.

Keywords

stroke, gene expression, oxidative modification of protein, glutathione

About the Authors

H. V. Zanginyan

Institute of Molecular Biology, National Academy of Sciences
Armenia
PhD (Biology), Research Associate, Laboratory of Molecular Membranology

L. M. Hovsepyan

Institute of Molecular Biology, National Academy of Sciences
Armenia
PhD (Biology), Leading Research Associate, Laboratory of Molecular Membranology

G. S. Kazaryan

Institute of Molecular Biology, National Academy of Sciences
Armenia
PhD (Biology), Research Associate, Laboratory of Molecular Membranology

G. V. Zakaryan

Institute of Molecular Biology, National Academy of Sciences
Armenia
PhD (Biology), Research Associate, Laboratory of Molecular Membranology

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For citations:

Zanginyan H.V., Hovsepyan L.M., Kazaryan G.S., Zakaryan G.V. АNALYSIS OF THE EXPRESSION LEVEL OF T-CELL GENES AND OXIDATIVE PROCESSES IN STROKE. Medical Immunology (Russia). 2019;21(2):251-256. (In Russ.) https://doi.org/10.15789/1563-0625-2019-2-251-256

This work is licensed under a Creative Commons Attribution 4.0 License.

ISSN 1563-0625 (Print)
ISSN 2313-741X (Online)

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	Title	подрисуночные подписи
	Date	2018-06-14

	Title	английский перевод заголовков и содержания таблиц и рисунков
	Date	2018-06-14

	Title	список использованной литературы
	Date	2018-06-14

	Title	оригинальная статья
	Date	2018-06-14

	Title	Неозаглавлен
	Type	Исследовательские инструменты
	Date	2018-06-06

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Medical Immunology (Russia)

АNALYSIS OF THE EXPRESSION LEVEL OF T-CELL GENES AND OXIDATIVE PROCESSES IN STROKE

Full Text:

Abstract

Keywords

About the Authors

References

Supplementary files

Review

For citations:

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