ОСОБЕННОСТИ МЕСТНОГО И СИСТЕМНОГО ИММУНИТЕТА И МОРФОФУНКЦИОНАЛЬНОЕ СОСТОЯНИЕ ЭНДОМЕТРИЯ У ЖЕНЩИН С АНОВУЛЯТОРНЫМ СИНДРОМОМ

Резюме. У женщин с ановуляторным синдромом и нарушением репродуктивной функции персистирующая ациклическая гипоэстрогенемия и недостаточность прогестерона связаны с нарушением морфологической структуры эндометрия, повышенной экспрессией рецепторов эстрогенов, прогестерона, перераспределением NK-клеток с преобладанием CD16+NK-клеток в эндометрии, при этом сниженное количество CD16+NK-клеток и цитотоксических CD8+Т-лимфоцитов в крови сочеталось с повышением уровнем IFNγ в сыворотке и увеличением спонтанной продукции TNFα.

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