mimmunМедицинская иммунологияMedical Immunology (Russia)1563-06252313-741XSPb RAACI10.15789/1563-0625-2008-4-5-353-360mimmun-189Research ArticleОРИГИНАЛЬНЫЕ СТАТЬИORIGINAL ARTICLESОСОБЕННОСТИ МЕСТНОГО И СИСТЕМНОГО ИММУНИТЕТА И МОРФОФУНКЦИОНАЛЬНОЕ СОСТОЯНИЕ ЭНДОМЕТРИЯ У ЖЕНЩИН С АНОВУЛЯТОРНЫМ СИНДРОМОМFEATURES OF LOCAL AND SYSTEMIC IMMUNITY, AND MORPHO-FUNCTIONAL STATE OF ENDOMETRIUM IN WOMEN WITH ANOVULATORY SYNDROMEМихнинаЕ. А.MichninaE. A.kalinina@arcem.spb.ruКомаровЕ. К.KomarovE. K.kalinina@arcem.spb.ruДавыдоваН. И.DavydovaN. I.kalinina@arcem.spb.ruЭллинидиВ. Н.EllinidyV. N.kalinina@arcem.spb.ruКалининаН. М.KalininaN. M.kalinina@arcem.spb.ruДобротворцеваО. А.DobrotvorcevaO. A.kalinina@arcem.spb.ruНаучно-исследовательский институт акушерства и гинекологии им. Д.О. Отта РАМН, Санкт-ПетербургRussian FederationВсероссийский Центр экстренной и радиационной медицины МЧС России им. А.С. Никифорова, Санкт-ПетербургRussian Federation200817072014104-5353360Copyright © Михнина Е.А., Комаров Е.К., Давыдова Н.И., Эллиниди В.Н., Калинина Н.М., Добротворцева О.А., 20142014Михнина Е.А., Комаров Е.К., Давыдова Н.И., Эллиниди В.Н., Калинина Н.М., Добротворцева О.А.Michnina E.A., Komarov E.K., Davydova N.I., Ellinidy V.N., Kalinina N.M., Dobrotvorceva O.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.mimmun.ru/mimmun/article/view/189

Резюме. У женщин с ановуляторным синдромом и нарушением репродуктивной функции персистирующая ациклическая гипоэстрогенемия и недостаточность прогестерона связаны с нарушением морфологической структуры эндометрия, повышенной экспрессией рецепторов эстрогенов, прогестерона, перераспределением NK-клеток с преобладанием CD16+NK-клеток в эндометрии, при этом сниженное количество CD16+NK-клеток и цитотоксических CD8+Т-лимфоцитов в крови сочеталось с повышением уровнем IFNγ в сыворотке и увеличением спонтанной продукции TNFα.

Abstract. Persisting acyclic hypoestrogenemia and progesterone insufficiency in the women with anovulatory syndrome and altered reproductive functions are associated with disturbed endometrial morphology, increased expression of receptors for estrogenes, progesterone, redistribution of NK cells with predominance of CD16+NK cells in endometrium. Meanwhile, decreased number of CD16+ NK cells and cytotoxic CD8+ T cells in blood was accompanied by increased serum IFNγ levels, and enhanced spontaneous production of TNFα. (Med. Immunol., vol. 10, N 4-5, pp 353-360).

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The authors declare that there are no conflicts of interest present.