CYTOKINE PROFILE IN PREGNANT WOMEN WITH METABOLIC DISORDERS
https://doi.org/10.15789/1563-0625-2017-3-301-306
Abstract
Serum concentrations of cytokines (IL-2, IL-6, IL-8, IL-10, GM-CSF, IFNγ, TNFα) were determined in blood serum of pregnant women with different types of metabolic disorders, i.e., gestational diabetes, obesity, and a combination of those disorders. The study was performed by means of flow fluorimetry, using a multiplex test system. Changes of cytokine profiles in pregnant women with overweight or obesity, and pregnant women with gestational diabetes showed some similarities. In pregnant women with overweight or obesity we have found an increase in blood concentrations of IL-2, IL-6, IL-10, IFNγ, and TNFa. Meanwhile, an increase in blood levels of IL-2, IL-6, IL-10 and TNFα was revealed in pregnant women with gestational diabetes. The changes in cytokine profile were most pronounced in cases of pregnancy complicated with gestational diabetes and obesity. In these women, increased IL-6, TNFα, GM-CSF and IFNg concentrations were revealed in blood, along with low contents of IL-2 and IL-10. Potential causes and consequences of suggested subclinical inflammation in pregnant women are discussed. We conclude that pregnant women with metabolic disorders may develop a subclinical inflammation at the early stages of obesity, or metabolic disturbances.
About the Authors
T. S. Prokhorenko
Siberian State Medical University, Tomsk
Russian Federation
PhD (Medicine), Research Associate, Central Research Laboratory
Russian Federation
PhD (Medicine), Research Associate, Central Research Laboratory
A. P. Zima
Siberian State Medical University, Tomsk
Immanuel Kant Baltic Federal University, Kaliningrad
Russian Federation
PhD, MD (Medicine), Main Research Associate, Central Research Laboratory, Professor, Department of Pathophysiology, Siberian State Medical University, Tomsk; Senior Research Associate, Laboratory of Immunology and Cell Biotechnolog, Immanuel Kant Baltic Federal University, Kaliningrad
Russian Federation
PhD, MD (Medicine), Main Research Associate, Central Research Laboratory, Professor, Department of Pathophysiology, Siberian State Medical University, Tomsk; Senior Research Associate, Laboratory of Immunology and Cell Biotechnolog, Immanuel Kant Baltic Federal University, Kaliningrad
T. V. Saprina
Siberian State Medical University, Tomsk
Russian Federation
PhD, MD (Medicine), Professor, Department of Endocrinology and Diabetology
Russian Federation
PhD, MD (Medicine), Professor, Department of Endocrinology and Diabetology
V. V. Novitskiy
Siberian State Medical University, Tomsk
Russian Federation
PhD, MD (Medicine), Professor, Full Member, Russian Academy of Sciences, Head, Department of Pathophysiology
Russian Federation
PhD, MD (Medicine), Professor, Full Member, Russian Academy of Sciences, Head, Department of Pathophysiology
N. M. Todosenko
Immanuel Kant Baltic Federal University, Kaliningrad
Russian Federation
Junior Research Associate, Laboratory of Immunology and Cell Biotechnologies
Russian Federation
Junior Research Associate, Laboratory of Immunology and Cell Biotechnologies
L. S. Litvinova
Immanuel Kant Baltic Federal University, Kaliningrad
Russian Federation
PhD, MD (Medicine), Head, Laboratory of Immunology and Cell Biotechnology
Russian Federation
PhD, MD (Medicine), Head, Laboratory of Immunology and Cell Biotechnology
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Review
For citations:
Prokhorenko T.S., Zima A.P., Saprina T.V., Novitskiy V.V., Todosenko N.M., Litvinova L.S. CYTOKINE PROFILE IN PREGNANT WOMEN WITH METABOLIC DISORDERS. Medical Immunology (Russia). 2017;19(3):301-306. (In Russ.) https://doi.org/10.15789/1563-0625-2017-3-301-306
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