CYTOKINE CONTENTS IN Th1- AND Th17-TYPE LYMPHOCYTES IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE
https://doi.org/10.15789/1563-0625-2016-3-287-290
Abstract
We studied cytokine profiles relevant to the Th1 and Th17 modes of immune response in 116 patients with mild, moderate and severe chronic obstructive pulmonary disease (COPD). Relative contents of Th1- and Th17-type lymphocytes were evaluated by serum levels of specific cytokines: TNFα, IL-6, IL-10,IL-17A, IL-21, IFNγ, TGF-β1. We found that the shift in balance of pro- and anti-inflammatory cytokines is typical to both Th1 and Th17 immune response types in COPD of different severity. The variety of immune response types was achieved due to activation of different effector cells. I.e., the Th1 response was associated with macrophage activation and IFNγ induction, whereas domination of Th17 response was accompanied by activation of neutrophils, and increased synthesis of IL-17, IL-21. The Th17 type of immune response was shown to prevail in severe COPD. Thus, the certain types of immune disorders in COPD presume application of combined therapy including immunocorrective drugs which are able to suppress inflammation and correct the cytokine imbalances.
About the Authors
E. G. Lobanova
Far Eastern Research Centre of Respiratory Physiology and Pathology – Institute of Medical Climatology and Rehabilitation, Vladivostok Branch, Vladivostok, Russian Federation
Russian Federation
Russian Federation
690105, Russian Federation, Vladivostok, Russkaya str., 73g. Phone: 7 (423) 278-82-01 PhD (Medicine), Research Associate, Laboratory of Biomedical Research
E. P. Kalinina
Far Eastern Research Centre of Respiratory Physiology and Pathology – Institute of Medical Climatology and Rehabilitation, Vladivostok Branch, Vladivostok, Russian Federation
Russian Federation
Russian Federation
PhD, MD (Medicine), Senior Research Associate, Laboratory of Rehabilitation Treatment
Yu. K. Denisenko
Far Eastern Research Centre of Respiratory Physiology and Pathology – Institute of Medical Climatology and Rehabilitation, Vladivostok Branch, Vladivostok, Russian Federation
Russian Federation
Russian Federation
PhD, MD (Biology), Head, Laboratory of Biomedicine Researches
References
1. Всемирная организация здравоохранения. Хроническая обструктивная болезнь легких (ХОБЛ) // Информационный бюллетень, 2011. № 315. [World Health Organization. Chronic obstructive pulmonary disease (COPD). Informatsionnyy byulleten’ = News Bulletin, 2011, no. 315. (In Russ.)]
2. Зарембо И.А. Хроническая обструктивная болезнь легких: распространенность и смертность // Аллергология, 2006. № 1. С. 39-43. Zarembo I.A. Chronic obstructive pulmonary disease: prevalence and mortality. Allergologiya = Allergology , 2006, no. 1, pp. 39-43. (In Russ.)]
3. Калинина Е.П., Лобанова Е.Г., Антонюк М.В. Иммунометаболические фенотипы хронической обструктивной болезни легких у мужчин // Медицинская иммунология, 2014. Т.16, № 4. С. 375-380. [Kalinina E.P., Lobanova E.G., Antonyuk M.V. Immune phenotypes of chronic obstructive pulmonary disease in men. Meditsinskaya immunologiya = Medical Immunology (Russia), 2014, Vol. 16, no. 4, pp. 375-380. (In Russ.)] http://dx.doi.org/10.15789/1563-0625-2014-4-375-380
4. Лобанова Е.Г., Калинина Е.П., Кнышова В.В., Антонюк М.В., Гельцер Б.И., Денисенко Ю.К., Гвозденко Т.А. Особенности регуляции иммунного ответа у пациентов с коморбидным течением хронической обструктивной болезни легких и бронхиальной астмы // Пульмонология, 2014. № 6. С. 5-10. [Lobanova E.G., Kalinina E.P., Knyshova V.V., Antonyuk M.V., Geltser B.I., Denisenko Yu.K., Gvozdenko T.A. Features of the regulation of the immune response in patients with chronic obstructive pulmonary disease and concomitant asthma. Pul`monologiya = Pulmonology, 2014, no. 6, pp. 5-10. (In Russ.)]
5. Afzali B., Lombardi G., Lecher R.I., Lord G.M. The role of T helper 17 (Th17) and regulatory T cells (Treg) in human organ transplantation and autoimmune disease. J. Clinical and Experimental Immunology, 2007, Vol. 148, pp. 32-46.
6. Annunziato F., Cosmi L., Santarlasci V., Maggi L., Liotta F., Mazzinghi B., Parente E., Fili L., Ferri S., Frosali F., Giudici F., Romagnani P., Parronchi P., Tonelli F., Maggi E., Romagnani S. Phenotypic and functional features of human Th17 cells. J. Exp. Med., 2007, Vol. 204, pp. 1849-1861.
Review
For citations:
Lobanova E.G., Kalinina E.P., Denisenko Yu.K. CYTOKINE CONTENTS IN Th1- AND Th17-TYPE LYMPHOCYTES IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE. Medical Immunology (Russia). 2016;18(3):287-290. (In Russ.) https://doi.org/10.15789/1563-0625-2016-3-287-290
Views:
1187
Email this article 