Preview

Medical Immunology (Russia)

Advanced search

EXPERIENCE IN LOCAL IMMUNOCORRECTION IN TREATMENT OF CHRONIC WOUNDS

https://doi.org/10.15789/1563-0625-2010-3-227-234

Abstract

 In this article, we present results of local treatment of purulent wounds caused by various agents, in 232 patients, using local immunocorrection techniques combined with therapeutic application of nitrogen monoxide (NO). A series of immunological, cytological, microbiological researches have been carried out, showing a direct antibacterial effect of myelopid has been defined, and appropriate criteria have been developed for scoring intensity of inflammation affecting soft tissues. A justification for combined therapy with NО and myelopid has been obtained, and a method of local treatment of wound infections has been offered and patented. Basing on these experimental and clinical studies, as well as dynamic indices of wound process, we have shown a benefit from local immunocorrection by means of combined NО/myelopid treatment for complex therapy of purulent wounds.

About the Authors

M. A. Khalilov
ГОУ ВПО «Орловский государственный университет», Медицинский институт, г. Орел
Russian Federation


I. A. Snimchsikova
ГОУ ВПО «Орловский государственный университет», Медицинский институт, г. Орел
Russian Federation


References

1. Липатов К.В., Сопромадзе М.А., Шехтер А.Б., Емельянов А.Ю., Грачев С.В. Использование газового потока, содержащего оксид азота (NO-терапия), в комплексном лечении гнойных ран//Хирургия. -2002. -№ 2. -С. 41-43.

2. Ковальчук Л.В., Ганковская Л.В., Мороз А.Ф. Противомикробные пептиды иммунной системы: клинические аспекты//Аллергология и иммунопатология. -2003. -Т. 4, № 2. -С. 20-26.

3. Кокряков В.Н. Очерки о врожденном иммунитете. -СПб.: Наука. -2006. -261 с.

4. Снимщикова И.А., Халилов М.А., Медведев А.И., Новикова Е.П., Гострый А.В. Современные подходы к диагностике и лечению гнойно-воспалительных заболеваний и раневой инфекции//Вестник РГМУ, 2008. -№ 4. -С. 95-98.

5. Стойко Ю.М., Мелехов П.А., Смехов С.Ю. Применение ранних швов в комплексном лечении гнойных ран//Вестник хирургии, 2003. -Т. 162. -№ 3. -С. 10-15.

6. Badiavas E.V., Falanga V. Treatment of chronic wounds with bone marrow-derived cells//Arch. Dermatol. -2003. -N 139. -Р. 510-516.

7. Deepak V. Composition of Wound Fluid from Pressure Ulcers Treated with Negative Pressure Wound Therapy Using V.A.C.//Wounds. -2006. -Vol. 18. -P. 119-126.

8. Drosou A., Falabella A., Kirsner R.S. Antiseptics on wounds: An area of controversy//Wounds. -2003. -Vol. 15, N 5. -Р. 149-166.

9. Falanga V. Wound Bed Preparation in Practice//Ewma Journal. -2004. -Vol. 4, N 2. -Р. 2-5.

10. Falanga V., Isaacs C., Paquette D. Wounding of bioengineered skin: cellular and molecular aspects after injury//J. Invest. Dermatol. -2002. -Vol. 119, N 3. -Р. 653-660.

11. Harder J., Glaser R., Schroder J.M. Review: Human antimicrobial proteins effectors of innate immunity //Innate Immunity. - 2007. - Vol. 13, N 6. - Р. 317-338.

12. Kenshi Yamasaki, Gallo Richard L. Antimicrobial peptides in human skin disease // European Journal of Dermatology. - 2008. - Vol. 18. - P. 11-21.

13. Klebanoff S.J. Myeloperoxidase: friend and foe//Journal of Leukocyte Biology. -2005. -Vol. 77, N 5. -Р. 598-625.

14. Reichner J.S., Meszaros A.J., Louis C.A. Molecular and metabolic evidence for the restricted expression of inducible nitric oxide synthase in healing wounds//American Journal of Pathology. -1999. -N 154. -P. 1097-1104.

15. Valenti P., Antonini G. Lactoferrin: an important host defence against microbial and viral attack//Cell Molecular Life Science. -2005. -Vol. 62. -Р. 2576-2587.

16. Saxena V. Vacuum-assisted closure: microdeformations of wounds and cell proliferation//Plast. Reconstr. Surg. -2004. -Vol. 114, N 5. -Р. 1086-1096.

17. Schultz G., Sibbald G., Falanga V. Wound bed preparation: A systematic approach to wound management.//Wound Rep. Regen. -2003, N 11. -Р. 1-28.

18. Zanetti M. Cathelicidins, multifunctional peptides of the innate immunity//Journal of Leukocyte Biology. -2004. -Vol. 75. -Р. 39-48.


Review

For citations:


Khalilov M.A., Snimchsikova I.A. EXPERIENCE IN LOCAL IMMUNOCORRECTION IN TREATMENT OF CHRONIC WOUNDS. Medical Immunology (Russia). 2010;12(3):227-234. (In Russ.) https://doi.org/10.15789/1563-0625-2010-3-227-234

Views: 818


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 1563-0625 (Print)
ISSN 2313-741X (Online)