PROMOTER POLYMORPHISM OF IL-1β GENE IN PATIENTS WITH A HISTORY OF ACUTE MYOCARDIAL INFARCTION
https://doi.org/10.15789/1563-0625-2010-3-219-226
Abstract
We have performed analysis of associations between IL-1β gene promoter polymorphism (-511C/T and -31 T/C variants), and conventional cardiovascular risk factors in the patients living in the West Siberia who had previously a history of myocardial infarction (MI). We are shown a strong linkage disequilibrium between IL-1β -31C/T (rs1143627), and IL-1β-511T/C (rs16944). Significant differences in frequency distributions of some compound genotypes were observed between healthy and patients with a history of MI. E.g., frequency of IL-1β-31CC/-511CT genotype was detected in 5.5 % of healthy population, while being absent among MI patients. A frequency of IL-1β (-31/-511) CC/CT genotype showed significant differences between MI patients under 55 years, as compared to healthy persons. Hence, the analyzed IL-1β promoter polymorphisms may be considered as an additional constitutional factor predisposing for vascular alterations.
About the Authors
A. V. Shevchenko
Учреждение Российской академии медицинских наук Научно-исследовательский институт клинической и экспериментальной лимфологии Сибирского отделения РАМН, г. Новосибирск
Russian Federation
Russian Federation
O. V. Golovanova
Учреждение Российской академии медицинских наук Научно-исследовательский институт клинической и экспериментальной лимфологии Сибирского отделения РАМН, г. Новосибирск
Russian Federation
Russian Federation
V. I. Konenkov
Учреждение Российской академии медицинских наук Научно-исследовательский институт клинической и экспериментальной лимфологии Сибирского отделения РАМН, г. Новосибирск
Russian Federation
Russian Federation
M. I. Voevoda
Учреждение Российской академии медицинских наук Научно-исследовательский институт терапии
Сибирского отделения РАМН, г. Новосибирск
Russian Federation
Russian Federation
V. N. Maximov
Учреждение Российской академии медицинских наук Научно-исследовательский институт терапии
Сибирского отделения РАМН, г. Новосибирск
Russian Federation
Russian Federation
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Review
For citations:
Shevchenko A.V., Golovanova O.V., Konenkov V.I., Voevoda M.I., Maximov V.N. PROMOTER POLYMORPHISM OF IL-1β GENE IN PATIENTS WITH A HISTORY OF ACUTE MYOCARDIAL INFARCTION. Medical Immunology (Russia). 2010;12(3):219-226. (In Russ.) https://doi.org/10.15789/1563-0625-2010-3-219-226
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