PERIPHERAL BLOOD SUBPOPULATION OF LYMPHOCYTES OF PATIENTS WITH AGE-RELATED MACULAR DEGENERATION
https://doi.org/10.15789/1563-0625-2015-5-461-466
Abstract
The article presents results of studies concerning subрopulations of peripheral blood lymphocyte in the patients at early stages of age-related macular degeneration (AMD), being compared with healthy elderly persons (risk group for AMD), and young adults without ophthalmological problems. We have revealed an increase in absolute counts and percentages of the cytotoxic cells (СD3+СD8+), and double-positive T cell subpopulations (СD3+CD4+СD8+), like as of B-lymphocyte contents, higher frequency of their increased content in peripheral blood of the patients with early and intermediate stages of AMD and healthy older people, as compared with young controls, thus allowing to suggest a potential role of these shifts in lymphocyte subpopulations for the AMD pathogenesis.
About the Authors
N. V. Balatskaya
Moscow Helmholtz Research Institute of Eye Diseases
Russian Federation
Russian Federation
PhD (Biology), Leading Research Associate, Department of Immunology and Virology.
Address for correspondence: Balatskaya Natalia V. The Moscow Helmholtz Research Institute of Eye Diseases 105062,Russian Federation,Moscow, SadovayaChernogryazskaya str., 14/19. Phone: 7 (916) 976-61-27. E-mail: balnat07@rambler.ru
E. A. Eremeeva
Moscow Helmholtz Research Institute of Eye Diseases
Russian Federation
Physician (Ophthalmology), Adult Advisory Out-patient Department
Russian Federation
Physician (Ophthalmology), Adult Advisory Out-patient Department
O. S. Slepova
Moscow Helmholtz Research Institute of Eye Diseases
Russian Federation
PhD, MD (Biology), Professor, Head, Department of Immunology and Virology
Russian Federation
PhD, MD (Biology), Professor, Head, Department of Immunology and Virology
M. V. Ryabina
Moscow Helmholtz Research Institute of Eye Diseases
Russian Federation
PhD (Medicine), Senior Research Associate, Department of Pathology of Retina and Optic Nerve �тельного нерва
Russian Federation
PhD (Medicine), Senior Research Associate, Department of Pathology of Retina and Optic Nerve �тельного нерва
I. G. Kulikova
Moscow Helmholtz Research Institute of Eye Diseases
Russian Federation
Senior Research Associate, Department of Immunology and Virology
Russian Federation
Senior Research Associate, Department of Immunology and Virology
E. S. Sorozhkina
Moscow Helmholtz Research Institute of Eye Diseases
Russian Federation
Research Associate, Department of Immunology and Virology
Russian Federation
Research Associate, Department of Immunology and Virology
References
1. Егоров Е.А., Романенко И.А. Возрастная макулярная дегенерация. Вопросы патогенеза диагностики и лечения // Клиническая офтальмология, 2009. Т. 10, № 1. С. 42-45. [Egorov E.A., Romanenko I.A. Age-related macular degeneration. Issues of pathogenesis, diagnostics and treatment. Klinicheskaya oftal`mologiya = Clinical Ophthalmology, 2009, Vol. 10, no. 1, pp. 42-45. (In Russ.)]
2. Нероев В.В., Рябина М.В., Чиковани К.Р., Нероева Н.В. Современные представления и подходы к лечению возрастной макулярной дегенерации // Российский офтальмологический журнал, 2008. Т. 1, № 1. С. 6-9. [Neroyev V.V., Ryabina M.V., Chikovani K.R., Neroyeva N.V. Modern ideas and approaches to the treatment of age-related macular degeneration. Rossiyskiy oftal`mologicheskiy zhurnal = Russian Ophthalmology Journal, 2008, Vol. 1, no. 1, pp. 6-9. (In Russ.)]
3. Панова И.Е., Тонких Н.А., Прокопьева М.Ю., Бухтиярова Н.В. Возрастная макулярная дегенерация с неоваскулярным ответом: особенности клинического течения, характеристика клеточного иммунитета // Вестник ОГУ, 2004. № 13. Специальный выпуск. С. 246-248. [Panova I.E., Tonkih N.A., Prokopyeva M.Y., Bukhtiyarov N.V. Age-related macular degeneration with neovascular response: clinical features, characteristic of cellular immunity. Vestnik OGU = Bulletin of OSU, 2004, no. 13, Special edition, pp. 246-248. (In Russ.)]
4. Петруня А.М., Евсюкова О.А. Влияние иммунотропных препаратов на клеточный иммунитет у пациентов с сухой формой ВМД // Український медичний альманах, 2012. Том 15, № 5. С. 128-132. [Petrunya A.M., Evsyukov A.A. The influence of immunotropic drugs on cellular immunity in patients with the dry form of AMD. Ukraїns`kiy medichniy al`manakh = Ukrainian Medical Almanac, 2012, Vol. 15, no. 5, pp. 128-132.]
5. Самотыя Е. Двойные негативные (ДН) и двойные позитивные (ДП) Т-лимфоциты при раке и неопухолевых заболеваниях // Онкологический журнал (Республика Беларусь), 2011. Т. 5, № 3 (19). С. 145.146. [Samotya E. Double-negative (DN) and double positive (DP) T cells in cancer and non-neoplastic diseases. Onkologicheskiy zhurnal (Respublika Belarus`) = Journal of Cancer (Republic of Belarus), 2011, Vol. 5, no. 3 (19), pp. 145.-146.]
6. Adamus G., Chew E.Y., Ferris F.L., Klein M.L. Prevalens of anti-retinal autoantibodies in different stages of Age-related macular degeneration. BMC Оphthalmol., 2014, Vol.14, р. 154.
7. Age-Related Eye Disease Study Research Group. A randomized, placebo-controlled, clinical trial of highdose supplementation with vitamins C and E, beta-carotene, and zinc for age-related macular degeneration and vision loss: AREDS. Arch. Ophthalmol., 2001, Vol. 119, рр.1417-1436.
8. Cousins W.S., Espinosa-Heidmann D.G., Miller D.M., Pereira-Simon S., Hernandez E.P., Chien H., MeierJewett C., Dix R.D. Macrophage activation associated with chronic murine cytomegalovirus infection results in more severe experimental choroidal neovascularisation. PLoS Pathogens., 2012, Vol. 8, no. 4. Available al: http://europepmc.org/articles/PMC3343109
9. Ding J.D., Kelly U., Groelle M., Christenbury J.G., Zhang W., Bowes Rickman C. The role of complement dysregulation in AMD mous models. Adv. Exp. Med. Biol., 2014, Vol. 801, рр. 213-219.
10. Grunin M., HagbiLevi S., Chowers I. The role of monocytes and macrophages in age-related macular degeneration. Adv. Exp. Med. Biol., 2014, Vol. 801, рр. 199-205.
11. Jiménez E., Sacedón R., Vicente .A, Hernández-López C., Zapata A.G., Varas A. Rat peripheral CD4+CD8+ T lymphocytes are partially immunocompetent thymus-derived cells that undergo postthymic maturation to become functionally mature CD4+ T lymphocytes. J. Immunol., 2012, Vol. 168, рр. 5005-5013.
12. Kalayoglu M.V., Bulal D., Aarroyo J., Gragoudas E.S., Miller J.W. Identification of Ghlamydia pneumoniае within human choroidal neovascular membranes secondary to age-related macular degeneration. Graefes Arch. Clin. Exp.Ophtalmol., 2005, Vol. 243, no. 11, рр.1080-1090.
13. Miller D.M., Ersinosa-Heidman D.G., Legra J., Dubovy S.R., Suner I.J., Sedmak D.D., Dix R.D., Cousins S.W. The association of prior cytomegalovirus infection with neovascular age-related macular degeneration. Am. J. Ophthalmol., 2004, Vol. 138, no. 3, рр. 323-328.
14. Nascimbeni M., Shin E.C., Chiriboga L., Kleiner D.E., Rehermann B. Peripheral CD4(+)CD8(+) T cells are differentiated effector memory cells with antiviral functions. Blood, 2004, Vol. 104, no. 2, рр. 478-486.
15. Toomey C. B., Kelly U., Saban D. R., Bowes Rickman C. Regulation of age-related macular degeneration-like pathology by complement factor H. Proc Natl Acad Sci USA. 2015 May 19. pii: 201424391. [Epub ahead of print].
Review
For citations:
Balatskaya N.V., Eremeeva E.A., Slepova O.S., Ryabina M.V., Kulikova I.G., Sorozhkina E.S. PERIPHERAL BLOOD SUBPOPULATION OF LYMPHOCYTES OF PATIENTS WITH AGE-RELATED MACULAR DEGENERATION. Medical Immunology (Russia). 2015;17(5):461-466. (In Russ.) https://doi.org/10.15789/1563-0625-2015-5-461-466
Views:
1136
Email this article 