CONTENTS OF CYTOKINES AND LACTOFERRIN IN ONCOLOGICAL PATIENTS
https://doi.org/10.15789/1563-0625-2008-1-67-70
Abstract
Abstract. The purpose of present work was to study the peculiarities of cytokine production in patients with malignant tumors, as exemplified by lymphoma and malignant melanoma. Sixty-five patients with malignancies (16 to 74 years old) have been surveyed. Contents of IL-1β, IL-4, TNFα and lactoferrin were studied in blood serum using enzyme immunoassay technique. The results of study have shown that the patients with melanoma have a significant reduction in IL-1-β and TNFα in blood serum, thus being suggestive for development of deficient immune response. In malignant lymphoma, the patients did also exhibit subnormal values of TNFα and IL-1β (below a threshold level of 5 pg/ml), thus supposing some deficiency in proinflammatory cytokine secretion. An interrelation was shown between the contents of lactoferrin and proinflammatory cytokines. After radical treatment of melanoma, like as in lymphoma patients free of В-symptoms, the lactoferrin contents were within normal limits, whereas in the patients with generalization of malignancy, and in lymphoma patients with В-symptoms, a trend to its increase has been established. Determination of the mentioned parameters in patients with lymphoma and malignant melanoma would provide useful diagnostic and predictive criteria in these clinical conditions.
About the Authors
T. I. Dolgikh
Омская государственная медицинская академия Федерального агентства по здравоохранению и социальному развитию
Russian Federation
Russian Federation
E. J. Bychkova
Омская государственная медицинская академия Федерального агентства по здравоохранению и социальному развитию
Russian Federation
Russian Federation
R. H. Galyulin
Омский областной клинический онкологический диспансер
Russian Federation
Russian Federation
References
1. Абидов М.Т., Калюжин О.В., Нелюбов М.В. Иммунотерапия хронических и острых воспалительных заболеваний // Terra medica nova. – 2001. – № 2. – С. 3-5.
2. Баранчук Н.В. Сравнительная оценка показателей иммунитета и иммунофенотипа лимфоидных клеток у больных лимфопролиферативными заболеваниями: Автореф. дис. … канд. мед. наук. – Пермь, 2003. – 20 с.
3. Козлов В.А. Некоторые аспекты проблемы цитокинов // Цитокины и воспаление. – 2002. – Т. 1, № 1. – С. 5-8.
4. Лихванцева В.Г. Роль цитокинов в патогенезе и прогнозе увеальной меланомы // Цитокины и воспаление. – 2002. – Т. 1, № 4. – С. 27-33.
5. Насонов Е.Л. Современные направления иммунологических исследований при хронических воспалительных и аутоиммунных заболеваниях человека // Терапевт. арх. – 2001. – № 8. – С. 43-46.
6. Реброва О.Ю. Статистический анализ медицинских данных. Применение пакета прикладных программ STATISTICA. – М.: МедиаСфера, 2002. – 312 с.
7. Серебряная Н.Б., Новик А.А., Волошин С.В., Новицкий А.В. Клиническое значение некоторых цитокинов при злокачественных неходжкинских лимфомах // Цитокины и воспаление. – 2002. – Т. 1, № 3. – С. 21-26.
8. Фрадкин С.З., Залуцкий И.В. Меланома кожи: Практ. пособие для врачей. – Мн.: Беларусь, 2000. – 221 с.
9. Hwang S.A., Wilk K.M., Bangale Y.A., Kruzel M.L., Actor J.K. Lactoferrin modulation of IL 12 and IL 10 response from activated murine leukocytes // Med. Microbiol. Immunol. – 2007. – Vol. 196, N 3. – P. 171-180.
10. Jabuulonska E., Kiluk M., Markiewicz W., Jabuulonski J. Priming effects of GM-CSF, IFN- gamma and TNFalpha on human neutrophil inflammatory cytokine production // Melanoma Res. – 2002. – Vol. 12, N 2. – Р. 123-128.
11. Kowalczuk A., Wiecek A., Franek E., Kokot F. Plasma concentration of leptin, neuropeptide Y and tumor necrosis factor alpha in patients with cancers, before and after radio- and chemotherapy // Pol. Arch. Med. Wewn. – 2001. – Vol. 106, N 2. – Р. 657-668.
12. Lauerova L., Dusek L., Simickova M., Kocák I., Vagundová M., Zaloudík J., Kovarík J. Malignant melanoma associates with Th1/Th2 imbalance that coincides with disease progression and immunotherapy response // Neoplasma. – 2002. – Vol. 49, N 3. – Р. 159-166.
13. Reynolds G.M., Billingham L.J., Gray L.J., Flavell J.R., Najafipour S., Crocker J., Nelson P., Young L.S., Murray P.G. Interleukin-6 expression by Hodgkin/Reed-Sternberg cells is associated with the presence of 'B' symptoms and failure to achieve complete remission in patients with advanced Hodgkin's disease // Br. J. Haematol. – 2002. – Vol. 118, N 1. – Р. 195-201.
14. Slifka M.K., Whitton J.L. Clinical implications of dysregulated cytokine production // J. Mol. Med. – 2000. – Vol. 78, N 2. – Р. 74-80.
15. Villani F., Viola G., Vismara C., Laffranchi A., Di Russo A., Viviani S., Bonfante V. Lung function and serum concentrations of different cytokines in patients submitted to radiotherapy and intermediate/high dose chemotherapy for Hodgkin's disease // Anticancer Res. – 2002. – Vol. 22, N 4. – Р. 2403-2408.
Review
For citations:
Dolgikh T.I., Bychkova E.J., Galyulin R.H. CONTENTS OF CYTOKINES AND LACTOFERRIN IN ONCOLOGICAL PATIENTS. Medical Immunology (Russia). 2008;10(1):67-70. (In Russ.) https://doi.org/10.15789/1563-0625-2008-1-67-70
Views:
1185
Email this article 