СORRECTION OF AUTOIMMUNE GLOMERULONEPHRITIS BY LETHAL IRRADIATION AND TRANSFER OF SYNGENEIC BONE MARROW CELLS IN AN EXPERIMENTAL MODEL
https://doi.org/10.15789/1563-0625-2010-3-191-198
Abstract
Mice with lupus-like autoimmune glomerulonephritis induced by chronic graft-versus-host reaction, have been treated with irradiation at lethal doses, followed by injection of bone marrow cells from syngeneic donors. Following such treatment, the autoimmune process was interrupted, as judged by disappearance of anti-DNA autoantibodies in peripheral blood. A drop in urine protein to normal values was also observed in the marrow recipients, thus being a characteristic sign of recovery from glomerulonephritis. Correction of the disease was confirmed by morphological data: the signs of oedema were diminished, and inflammatory reaction was found to be decreased in the kidneys of animals with lupus-like disorder after marrow transplantation.
About the Authors
O. T. Kudaeva
НИИ клинической иммунологии СО РАМН, г. Новосибирск
Russian Federation
Russian Federation
E. V. Goiman
НИИ клинической иммунологии СО РАМН, г. Новосибирск
Russian Federation
Russian Federation
E. V. Nenasheva
НИИ клинической иммунологии СО РАМН, г. Новосибирск
Russian Federation
Russian Federation
I. V. Majborodin
Институт химической биологии и фундаментальной медицины СО РАН, г. Новосибирск
Russian Federation
Russian Federation
O. P. Kolesnikova
НИИ клинической иммунологии СО РАМН, г. Новосибирск
Russian Federation
Russian Federation
V. A. Kozlov
НИИ клинической иммунологии СО РАМН, г. Новосибирск
Russian Federation
Russian Federation
References
1. Козлов В.А., Кудаева О.Т., Колесникова О.П., Сафронова И.В., Лактионов П.В., Рыкова Е.Ю., Обухова Л.А. Th1-и Th2-зависимые варианты хронической реакции трансплантат против хозяина//Иммунология. -2002. -23. -№ 3. -С. 143-146.
2. Колесникова О.П., Кудаева О.Т., Логинов В.А., Робинсон М.В., Колесникова С.М., Козлов В.А. Показатели эритро-и иммунопоэза в развитии аутоиммунных заболеваний, индуцированных хронической реакцией трансплантат против хозяина//Вестн. АМН СССР. -1991. -№ 12. -С. 13-16.
3. Кудаева О.Т., Ненашева Е.В., Козлов В.А. Определение содержания иммуноглобулинов в цельной крови//Иммунология. -200. -№ 3. -С. 189-191.
4. Кудаева О.Т., Гойман Е.В., Лыков А.П., Колесникова О.П., Козлов В.А. Влияние препаратов, изменяющих соотношение Th1/Th2, на частоту развития клинических вариантов хронической реакции трансплантат против хозяина//БЭБиМ. -2005. -№ 9. -С. 325-327.
5. Ткачев В.О., Ненашева Е.В., Гойман Е.В., Вольский Н.Н., Кудаева О.Т., Колесникова О.П. Уровень аутоантител к ДНК и метаболическая активность полиморфноядерных лейкоцитов в динамике хронической реакции трансплантат против хозяина//Иммунология. -2006. -№ 2. -С. 98-101.
6. Bi B., Schmitt R., Israilova M., Nishio H., Cantley L.G. Stromal cells protect against acute tubular injury via an endocrine effect//J. Am. Soc.Nephrol. -2007. -Vol. 18. -P. 2486-2496.
7. Bradford M.M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding//Anal. Biochem. -1976. -Vol. 72. -P. 248-254.
8. Gleichmann E., Pals S.T., Rolink A.G., Radaszkiewicz T., Gleichmann H. Graft-versus-host reactions: clues to the etiopathology of a spectrum of immunological diseases//Immunol. Today. -1984. -Vol. 5. -P. 324-332.
9. Hishikawa K., Fujita T. Stem cells and kidney disease//Hypertens Res. -2006. -Vol. 29. -P. 745-749.
10. Kimura K., Ida S., Shimada K., Kanai Y. Specificity of anti-nuclear antibodies induced in F1 mice undergoing the graft versus host reaction: isotypes and cross-reactivities//Clin. Exp. Immunol. -1987. -Vol. 69. -P. 385-393.
11. Kimura M., Gleichmann E. Depressed antibody responses to exogenous antigens in mice with lupus-like graft-versus-host disease//Clin. Immunol. Immunopathol. -1987. -Vol. 43, N 1. -P. 97-109.
12. Kolesnikova O.P., Kudaeva O.T., Sukhenko T.G., Tuzova M.N., Saphronova I.V. The correction of combined immuno- and hemopoiesis disordes induced by graft-versus-host reaction // Russian J. Immunol. - 2001. - Vol. 6, N 2. - P. 177-186.
13. Krenger, W., Rossi S., Piali L., Hollander G.A. Thymic atrophy in murine acute graft-versus-host disease is effected by impaired cell cycle progression of host pro-T and pre-T cells // Blood. - 2000. - Vol. 96. - P. 347-354.
14. Maeda T., Nomoto K. Anti-T cell receptor antibody treatment of mice with lupus-like graft versus host disease: suppression of glomerulonephritis without reduction in anti-DNA antibody levels//J. Rheumatol. -1995. -Vol. 22, N 12. -P. 2259-2265.
15. Meziere C., Stockl F., Batsford J., Vogt A., Muller S. Antibodies to DNA, chromatin core particles and histones in mice with GvHD and their involvement in glomerular injury//Clin. Exp.Immunol. -1994. -Vol. 98. -P. 287-294.
16. Morris S.C., Cheek R.L., Cohen P.L., Eisenberg R.A. Autoantibodies in chronic graft versus host result from cognate T-B interactions//J. Exp. Med. -1990. -Vol. 171. -P. 503-17.
17. Murphy W.J. Revisiting graft-versus-host disease models of autoimmunity: new insights in immune regulatory processes//J. Clin. Invest. -2000. -Vol. 106, N 6. -P. 745-747.
18. Poulsom R., Prodromidi E.I., Pusey C.D., Cook H.T. Cell therapy for renal regeneratio -time for some joined-up thinking?//Nephrol. Dial Transplant. -2006. -Vol. 21. -P. 3349-3353.
19. Slayback D.L., Dobkins J.A., Harper J.M., Allen R.D. Genetic factors influencing the development of chronic graft-versus-host disease in a murine model//Bone Marrow Transplantation. -2000. -Vol. 26. -P. 931-938.
20. Treurniet R.A., Bergijk E.C., Baelde J.J., De Heer E., Hoedemaeker P.J., Bruijn J.A. Gender-related influences on the development of chronic graft-versus-host disease-induced experimental lupus nephritis // Clin. Exp. Immunol. - 1993. - Vol. 91, N 3. - P. 442-448.
21. Van der Brink M.R., Moore E., Ferrara J.L., Burakoff S.J. Graft-versus-host-disease-associated thymic damage results in the appearance of T cell clones with anti-host reactivity // Transplantation. - 2000. - Vol. 69. - P. 446-449.
22. Via C.S., Shearer G.M. T cell interactions in autoimmunity: insights from a murine model of graft-versus-host disease//Immunol. Today. -1988. -Vol. 9. -P. 207.
23. Waldman M., Madaio M.P. Pathogenic autoantibodies in lupus nephritis//Lupus. -2005. -Vol. 14. -P. 19-24.
Review
For citations:
Kudaeva O.T., Goiman E.V., Nenasheva E.V., Majborodin I.V., Kolesnikova O.P., Kozlov V.A. СORRECTION OF AUTOIMMUNE GLOMERULONEPHRITIS BY LETHAL IRRADIATION AND TRANSFER OF SYNGENEIC BONE MARROW CELLS IN AN EXPERIMENTAL MODEL. Medical Immunology (Russia). 2010;12(3):191-198. (In Russ.) https://doi.org/10.15789/1563-0625-2010-3-191-198
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