CHARACTERISTICS OF IMMUNE HOMEOSTASIS IN PATIENTS WITH BASAL CELL SKIN CANCER FROM KOPEYSK URBAN DISTRICT
https://doi.org/10.15789/1563-0625-2014-5-457-464
Abstract
Patterns of immune response, cytokine- and NO-ergic mechanisms and their role in the development of basal-cell skin cancer were evaluated in population of an industrialized region. Multiple forms of basal-cell skin cancer and primary multiple cancer were characterized by the evidence of Th2-dependent imbalance of immune response, decreased cytolytic potential, increase of EGF, TGF-β, IL-1β, IL-4, IFNγ, lactoferrin levels, thus suggesting a particular immune defense strategy in malignant growth.
About the Authors
A. V. Zurochka
Institute of Immunology and Physiology, Russian Academy of Sciences, Ural Branch, Ekaterinburg, Russian Federation
South Ural State National Research University, Cheliabinsk, Russian Federation
Russian Federation
Russian Federation
PhD, MD, Professor, Institute of Immunology and Physiology, Russian Academy of Sciences, Ural Branch 454005, Russian Federation, Chelyabinsk, Televisionnaya str., 6, apt 36. Phone: 7 (919) 307-75-98.
O. I. Ekimova
Regional Dermatovenereological Health Center No 3, Kopeysk, Russian Federation
Russian Federation
Russian Federation
Dermato-venereologist, Regional Dermatovenereological Health Center No 3, Kopeysk, Russian Federation
T. P. Pisklakova
South Ural State National Research University, Cheliabinsk, Russian Federation
Russian Federation
Russian Federation
PhD, MD (Medicine), Professor, South Ural State National Research University, Cheliabinsk, Russian Federation
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Review
For citations:
Zurochka A.V., Ekimova O.I., Pisklakova T.P. CHARACTERISTICS OF IMMUNE HOMEOSTASIS IN PATIENTS WITH BASAL CELL SKIN CANCER FROM KOPEYSK URBAN DISTRICT. Medical Immunology (Russia). 2014;16(5):457-464. (In Russ.) https://doi.org/10.15789/1563-0625-2014-5-457-464
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