EVALUATION OF CYTOKINE GENE POLYMORPHISM IN B CELL LYMPHOID MALIGNANCIES
https://doi.org/10.15789/1563-0625-2014-5-431-436
Abstract
Previous studies with some solid tumors has shown that polymorphisms of certain cytokine genes may be used as predictors of clinical outcome in the patients. It seemed important to evaluate potential correlations between production of certain pro- and anti-inflammatory cytokines and co-receptor molecules, and promoter polymorphism of the cytokine genes involved into regulation of cell proliferation, differentiation, apoptosis, lipid metabolism and blood clotting in the patients with hematological malignancies. The article contains our results concerning associations between of IL-1β, -2, -4, -10, -17, TNFα, and allelic polymorphisms of their genes in 62 patients with B cell lymphoid malignancies in an ethnically homogenous group (self-identified as Russians. We have shown that the GА and AA genotypes of the G-308A polymorphism in TNFα gene are significantly associated with increased production of this cytokine, being more common in aggressive non-Hodgkin lymphomas, more rare in multiple myeloma and in indolent non-Hodgkin lymphomas.
About the Authors
E. L. Nazarova
Kirov Research Institute of Hematology and Blood Transfusion, Federal Medical and Biological Agency of Russia, Kirov, Russian Federation
Russian Federation
Russian Federation
Nazarova Elena L. PhD, Leading Research Associate, Kirov Research Institute of Hematology and Blood Transfusion, Federal Medical and Biological Agency of Russia 610027. Russian Federation, Kirov, Krasnoarmeiskaya str., 72. Phone: 7 (922) 920-89-01. Fax: 7 (8332) 54-97-31
V. I. Shardakov
Kirov Research Institute of Hematology and Blood Transfusion, Federal Medical and Biological Agency of Russia, Kirov, Russian Federation
Russian Federation
Russian Federation
PhD, MD (Medicine), professor, Head, Laboratory of Leukemia Immunology, Kirov Research Institute of Hematology and Blood Transfusion, Federal Medical and Biological Agency of Russia, Kirov, Russian Federation
V. T. Demyanova
Kirov Research Institute of Hematology and Blood Transfusion, Federal Medical and Biological Agency of Russia, Kirov, Russian Federation
Russian Federation
Russian Federation
PhD (Biology), Senior Research Associate, Kirov Research Institute of Hematology and Blood Transfusion, Federal Medical and Biological Agency of Russia, Kirov, Russian Federation
T. P. Zagoskina
Kirov Research Institute of Hematology and Blood Transfusion, Federal Medical and Biological Agency of Russia, Kirov, Russian Federation
Russian Federation
Russian Federation
PhD (Medicine), Associate Professor, Head, Hematology Clinics, Kirov Research Institute of Hematology and Blood Transfusion, Federal Medical and Biological Agency of Russia, Kirov, Russian Federation
E. N. Zotina
Kirov Research Institute of Hematology and Blood Transfusion, Federal Medical and Biological Agency of Russia, Kirov, Russian Federation
Russian Federation
Junior Research Associate, Federal Medical and Biological Agency of Russia, Kirov, Russian Federation
Russian Federation
Junior Research Associate, Federal Medical and Biological Agency of Russia, Kirov, Russian Federation
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Review
For citations:
Nazarova E.L., Shardakov V.I., Demyanova V.T., Zagoskina T.P., Zotina E.N. EVALUATION OF CYTOKINE GENE POLYMORPHISM IN B CELL LYMPHOID MALIGNANCIES. Medical Immunology (Russia). 2014;16(5):431-436. (In Russ.) https://doi.org/10.15789/1563-0625-2014-5-431-436
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