IMMUNE AND METABOLIC PHENOTYPES OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE IN MEN
https://doi.org/10.15789/1563-0625-2014-4-375-380
Abstract
This review concerns studies of compensatory mechanisms in the antioxidant defense, intensification of lipid peroxidation products, assays of local and systemic cytokine profile in COPD patients, thus allowing to determine the molecular phenotypes of systemic inflammatory response. The first of these phenotypes is characterized by certain biomarker combination, i.e., balanced lipid peroxidation and antioxidant defense system, many-fold increase in tissue and systemic concentrations of TFG-β1, high TNFα level. This phenotype is characterized by a moderate immunosuppression, balanced inflammation in respiratory tract. A set of biomarkers typical to the second phenotype may be characterized by activation of free radical lipid oxidation, high levels of of TNFα, bFGF and TGF-β1 secretion, increased sTNFα RI (p55), along with decreased synthesis of a chemoattractant IL-8 cytokine. This phenotype is characterized by an immunosuppressive imbalance causing inflammation in respiratory tract. The third phenotype is associated with the following biomarkers: inactivation of peroxidation processes, high-level secretion of TNFα, bFGF, and sTNFα RI (p55) and decreased TGF-β1 and IL-8 synthesis, thus resulting into imbalanced immunodeficient inflammation in respiratory tract.
About the Authors
E. P. Kalinina
Vladivostok Branch of the Far-Eastern Center of Respiration Physiology and Pathology, SB RAMS, Institute of Medical Climatology and Rehabilitative Treatment, Vladivostok
Russian Federation
Russian Federation
PhD, MD (Medicine), Senior Research Associate, Laboratory of Rehabilitation Treatment, Vladivostok
Branch of the Far-Eastern Center of Respiration Physiology and Pathology, SB RAMS, Institute of Medical Climatology and Rehabilitative Treatment
E. G. Lobanova
Vladivostok Branch of the Far-Eastern Center of Respiration Physiology and Pathology, SB RAMS, Institute of Medical Climatology and Rehabilitative Treatment, Vladivostok
Russian Federation
Russian Federation
PhD (Medicine), Research Associate, Laboratory of Biomedical Research, Vladivostok Branch of the Far-Eastern Center of Respiratory Physiology and Pathology SB RAMS, Institute of Medical Climatology and Rehabilitative Treatment
M. V. Antonyuk
Vladivostok Branch of the Far-Eastern Center of Respiration Physiology and Pathology, SB RAMS, Institute of Medical Climatology and Rehabilitative Treatment, Vladivostok
Russian Federation
Russian Federation
PhD, MD (Medicine), Professor, Head, Laboratory of Rehabilitation Treatment, Vladivostok Branch of the Far-Eastern Center of Respiration Physiology and Pathology, SB RAMS, Institute of Medical Climatology and Rehabilitative Treatment
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Review
For citations:
Kalinina E.P., Lobanova E.G., Antonyuk M.V. IMMUNE AND METABOLIC PHENOTYPES OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE IN MEN. Medical Immunology (Russia). 2014;16(4):375-380. (In Russ.) https://doi.org/10.15789/1563-0625-2014-4-375-380
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