GENETIC FACTORS IN IMMUNOPATHOGENESIS OF PSORIASIS AND PSORIATIC ARTHRITIS
https://doi.org/10.15789/1563-0625-2014-3-211-220
Abstract
There is a genetic predisposition to psoriasis (PS) and psoriatic arthritis (PsA), in which some cytokine genes are involved. Identification of polymorphic variants of immune response genes (i.e.,cytokines and their specific receptors) is a promising direction for studies of genetic risk factors responsible for development of skin and joint inflammation in psoriasis and PsA. Immune disorders characterized by the deviation of cytokine profile by Th1-type (IL-2, IFNγ, TNFα) play a leading role in immunopathogenesis of
psoriasis and psoriatic arthritis. The review deals with analysis of publications regarding the role of cytokine gene polymorphisms associated with clinical course of psoriasis and PsA. Further search for genetic markers
determining clinical risks of PS and PsA would be an important step in personalized approach to prediction of occurrence and clinical course of the disease, as well as to arrangement of preventive measures, in order to prevent potential progression of the disease.
About the Authors
M. V. Smolnikova
Research Institute for Medical Problems of the North, Siberian Branch of Russian Academy of Medical Sciences, Krasnoyarsk
Russian Federation
Russian Federation
PhD (Biology), Leading Research Associate, Laboratory of cellular molecular physiology and pathology, Research Institute for Medical Problems of the North, Siberian Branch of Russian Academy of Medical Sciences
S. V. Smirnova
Research Institute for Medical Problems of the North, Siberian Branch of Russian Academy of Medical Sciences, Krasnoyarsk
Russian Federation
Russian Federation
PhD, MD (Medicine), Professor, Deputy Director for Research, The head of the Division of Clinical Immunology and Cell Technologies, Research Institute for Medical Problems of the North, Siberian Branch of Russian Academy of Medical Sciences
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For citations:
Smolnikova M.V., Smirnova S.V. GENETIC FACTORS IN IMMUNOPATHOGENESIS OF PSORIASIS AND PSORIATIC ARTHRITIS. Medical Immunology (Russia). 2014;16(3):211-220. (In Russ.) https://doi.org/10.15789/1563-0625-2014-3-211-220
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