ВЛИЯНИЕ СЕКРЕТОРНЫХ ПРОДУКТОВ ТКАНИ ПЛАЦЕНТЫ НА ЭКСПРЕССИЮ ПОВЕРХНОСТНЫХ РЕЦЕПТОРОВ КЛЕТКАМИ ЛИНИИ ТНР-1

Резюме. В зоне маточно-плацентарного кровотока моноциты периферической крови матери подвергаются действию различных цитокинов и ростовых факторов, секретируемых тканью плаценты. Впоследствии эти клетки мигрируют в децидуальную ткань и играют важную роль в развитии и функционировании плаценты. Целью настоящего исследования явилось изучение влияния секреторных продуктов ткани плаценты, полученных при физиологической и осложненной гестозом беременностью, на экспрессию поверхностных рецепторов моноцитоподобными клетками линии ТНР-1. Секреторные продукты ткани плацент третьего триместра физиологической беременности приводили к снижению интенсивности экспрессии клетками линии ТНР-1 адгезионных молекул CD11а и CD18, а также молекул TRAIL, CD54, CD14 и VEGFR1 по сравнению с первым триместром. Под влиянием факторов, секретируемых тканью плаценты с гестозом, происходило увеличение интенсивности экспрессии молекул CD18 и CD54 и снижение интенсивности экспрессии VEGFR1 клетками линии ТНР-1 по сравнению с физиологической беременностью. Работа поддержана грантами Президента РФ №НШ-131.2012.7, СП-3492.2013.4, МК-1580.2013.7 и гранта РФФИ №13-04-00304 А.

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