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Медицинская иммунология

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ХРОНИЧЕСКАЯ КРАПИВНИЦА В ДЕТСКОМ ВОЗРАСТЕ. ФОРМЫ ХРОНИЧЕСКОЙ КРАПИВНИЦЫ У ДЕТЕЙ. ДИФФЕРЕНЦИАЛЬНАЯ ДИАГНОСТИКА (ЧАСТЬ II)

https://doi.org/10.15789/1563-0625-2013-4-313-324

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Аннотация

Резюме. Структура крапивницы у детей в последнее десятилетие претерпела изменения в связи с открытием аутоиммунной формы, на которую приходится от 30 до 52% от всех случаев хронической идиопатической крапивницы. Физические крапивницы диагностируются в 17-20% случаев и другие формы, в том числе аллергическая, выявляются менее чем в 5%. Разные типы хронической крапивницы имеют свои характерные иммунологические черты и клинические особенности. Продолжается совместная работа экспертной группы европейских аллергологов-иммунологов и дерматологов по уточнению диагностических критериев и подходов к профилактике и терапии этой патологии у детей.

Об авторах

Н. А. Синельникова
Санкт-Петербургский государственный педиатрический медицинский университет, Санкт-Петербург
Россия

заочный аспирант кафедры факультетской педиатрии

198097, пр. Стачек, 32, кв. 42. Тел.: 8 (921) 302-28-00. Факс: 8 (812) 542-80-14



Н. М. Калинина
Всероссийский центр экстренной и радиационной медицины МЧС России, Санкт-Петербург
Россия
д.м.н., профессор


Н. Д. Савенкова
Санкт-Петербургский государственный педиатрический медицинский университет, Санкт-Петербург
Россия

д.м.н., профессор, кафедра факультетской педиатрии



Список литературы

1. Астафьева Н.Г., Борзова Е.Ю., Горячкина Л.А., Данилычева И.В., Емельянов А.В., Кочергин Н.Г., Лусс Л.В. Российский национальный согласительный документ. Крапивница и ангиоотек: рекомендации для практических врачей // Российский аллергологический журнал. – 2008. – № 3. – С. 36-42. Astaf`eva N.G., Borzova E.Yu., Goryachkina L.A., Danilycheva I.V., Emel`yanov A.V., Kochergin N.G., Luss L.V. Rossiyskiy natsional`nyy soglasitel`nyy dokument. Krapivnitsa i angiootek: rekomendatsii dlya prakticheskikh vrachey [Russian national consensus. Urticaria and angioedema: recommendations for clinicians]. Rossiyskiy allergologicheskiy zhurnal – Russian Allergology Journal, 2008, no. 3, pp. 36-42.

2. Грибинюк А.И., Думбрава В.А., Ону В.Ф., Кирвас Е.Г., Серебрянская И.Е., Харя Г.Г., Андриеш Л.П., Корня Д.И., Бахнарел В.И. Вегетативный статус больных холинергической крапивницей // Международный журнал по иммунореабилитации. – 2009. – № 1. – C. 33а. Gribinyuk A.I., Dumbrava V.A., Onu V.F., Kirvas E.G., Serebryanskaya I.E., Harya G.G., Andriesh L.P., Kornya D.I., Bakhnarel V.I. Vegetativnyy status bol`nykh kholinergicheskoy krapivnitsey [Vegetative status in patients with cholinergic urticaria]. Mezhdunarodnyy zhurnal po immunoreabilitatsii – International Immunorehabilitation Journal, 2009, no. 1, p. 33a.

3. Данилычева И.В. Дермографическая крапивница. Патогенетические обобенности лечения цетиризином // Российский аллергологический журнал. – 2008. – № 2. – C. 82-86. Danilycheva I.V. Dermograficheskaya krapivnitsa. Patogeneticheskie obobennosti lecheniya tsetirizinom [Dermographic urticaria. Pathogenetic features of cetirizine treatment]. Rossiyskiy allergologicheskiy zhurnal – Russian Allergology Journal, 2008, no. 2, pp. 82-86.

4. Данилычева О.А., Бондаренко Н.Г., Купавцева О.А. Уртикарный васкулит: алгоритм диагностики // Медицинский вестник. – 2009. – № 20. – C. 489. Danilycheva O.A., Bondarenko N.G., Kupavtseva O.A. Urtikarnyy vaskulit: algoritm diagnostiki [Urticarial vasculitis: diagnostic algorithm]. Meditsinskiy vestnik – Medical Bulletin, 2009, no. 20, p. 489.

5. Добронравов В.А. Гипокомплементемический уртикарный васкулит: введение в клинику и иммунобиологию // Нефрология. – 2011. – № 1. – C. 17-26. Dobronravov V.A. Gipokomplementemicheskiy urtikarnyy vaskulit: vvedenie v kliniku i immunobiologiyu [Hypocomplementic urticarial vasculitis: introduction in clinic and immunobiology]. Nefrologiya – Nephrology, 2011, no. 1, pp. 17-26.

6. Ибрагимова Н.И., Гаджиев К.М. Этиопатогенетические варианты хронической крапивницы у детей // Педиатрия. – 2010. – № 2. – C. 48-50. Ibragimova N.I., Gadzhiev K.M. Etiopatogeneticheskie varianty khronicheskoy krapivnitsy u detey [Etiopathogenetic variants of chronic urticaria in children]. Pediatriya –Pediatrician, 2010, no. 2, pp. 48-50.

7. Мачарадзе Д.Ш. Холодовая крапивница: особенности диагностики и лечения // Лечащий врач. – 2010. – № 9. – C. 49. Macharadze D.Sh. Holodovaya krapivnitsa: osobennosti diagnostiki i lecheniya [Cold urticaria: particularity of diagnostic and treatment]. Lechashchiy vrach – The Practitioner 2010, no. 9, p. 49.

8. Некрасова Е.Е., Разваляева А.В., Маможинская Н.В. Разработка русской версии опросника CUQ2OL для изучения качества жизни у пациентов с хронической крапивницей // Саратовский научно-практический журнал. – 2010. – № 3. – C. 566-569. Nekrasova E.E., Razvalyaeva A.V., Mamozhinskaya N.V. Razrabotka russkoy versii oprosnika CU-Q2OL dlya izucheniya kachestva zhizni u patsientov s khronicheskoy krapivnitsey [The development of Russian version of inquirer CU-Q2OL for life quality education in patients with chronic urticaria]. Saratovskiy nauchno-prakticheskiy zhurnal – Saratov Scientific Journal, 2010, no. 3, pp. 566-569.

9. Орлова Е.А., Молотилова Б.А. Нейропептиды и «Нейрогенное воспаление» в патогенезе крапивницы // Практическая медицина. – 2011. – № 51. – C. 98-103. Orlova E.A., Molotilova B.A. Neyropeptidy i «Neyrogennoe vospalenie» v patogeneze krapivnitsy [Neuropeptides and “Neurogenic inflammation” in the pathogenesis of urticaria]. Prakticheskaya meditsina – Practical medicine, 2011, no. 51, pp. 98-103.

10. Пампура А.Н. Фармакотерапия хронической идиопатической крапивницы у детей // Российский аллергологический журнал. – 2010. – № 3. – C. 43-48. Pampura A.N. Farmakoterapiya khronicheskoy idiopaticheskoy krapivnitsy u detey [Pharmacotherapy of chronic idiopathic urticaria in children]. Rossiyskiy allergologicheskiy zhurnal – Russian Allergology Journal, 2010, no. 3, pp. 43-48.

11. Пампура А.Н., Соловей Т.Н. Современные подходы к диагностике и терапии крапивниц у детей. Российский Медицинский Журнал. – 2008. – № 23. – C. 1534. Pampura A.N., Solovey T.N. Sovremennye podkhody k diagnostike i terapii krapivnits u detey [Modern ways in diagnostic and therapy of urticaria in children]. Rossiyskiy Meditsinskiy Zhurnal – Russian Medical Journal, 2008, no. 23, p. 1534.

12. Таха Т.В. Новые возможности в терапии крапивницы // Российский Медицинский Журнал. – 2011. – № 11. – C. 678. Takha T.V. Novye vozmozhnosti v terapii krapivnitsy [New abilities in urticaria treatment]. Rossiyskiy Meditsinskiy Zhurnal – Russian Medical Journal, 2011, no. 11, p. 678.

13. Alyasin S., Hamidi M., Karimi A.A., Amiri A., Ghaffarpasand F., Ehsaei M.J. Correlation between clinical findings and results of autologous serum skin test in patients with chronic idiopathic urticaria. South Med. J.. 2011, vol. 104, pp. 111-115.

14. Andersen C.L., Kristensen T.K., Severinsen M.T., M ller M.B., Vestergaard H., Bergmann O.J., Hasselbalch H.C., Bjerrum O.W. Systemic mastocytosis – a systematic review. Danish Med. J., 2012, vol. 59, p. 4397.

15. Asero R., Cugno M., Tedeschi A. Activation of blood coagulation in plasma from chronic urticaria patients with negative autologous plasma skin test. J. Eur. Acad. Dermatol. Venereol., 2011, vol. 25, pp. 201-205.

16. Banerji A. Hereditary angioedema: classification, pathogenesis, and diagnosis. Allergy Asthma Proc., 2011, vol. 32, pp. 403-407.

17. Bannert C., Bidmon-Fliegenschnee B., Stary G., Hotzy F., Stift J., Nurko S., Sz pfalusi Z., Fiebiger E., Dehlink E. Fc-Epsilon-RI, the High Affinity IgE-Receptor, Is Robustly Expressed in the Upper Gastrointestinal Tract and Modulated by Mucosal Inflammation. PLoS One, 2012, vol. 7, e42066.

18. Bossi F., Frossi B., Radillo O., Cugno M., Tedeschi A., Riboldi P., Asero R., Tedesco F., Pucillo C. Mast cells are critically involved in serum-mediated vascular leakage in chronic urticaria beyond high-affinity IgE receptor stimulation. Allergy, 2011, vol. 66, pp. 1538-1545.

19. Brockow K., Ring J., Alvarez-Twose I., Orfao A., Escribano L. Extensive blistering is a predictor for severe complications in children with mastocytosis. Allergy, 2012, vol. 67, pp. 1323-1324.

20. Buck A., Christensen J., McCarty M. Hypocomplementemic urticarial vasculitis syndrome: a case report and literature review. Clin. Aesthet. Dermatol., 2012, vol. 5, pp. 36-46.

21. Caballero T., Baeza M.L., Caba as R., Campos A., Cimbollek S. Consensus statement on the diagnosis, management, and treatment of angioedema mediated by bradykinin. Part I. Classification, epidemiology, pathophysiology, genetics, clinical symptoms, and diagnosis. J. Investig. Allergol. Clin. Immunol., 2011, vol. 21, pp. 333-347.

22. Caballero T., Baeza M.L., Caba as R., Campos A., Cimbollek S. Consensus statement on the diagnosis, management, and treatment of angioedema mediated by bradykinin. Part I. Classification, epidemiology, pathophysiology, genetics, clinical symptoms, and diagnosis. J. Investig. Allergol. Clin. Immunol., 2011, vol. 21, pp. 422-441.

23. Castells M., Metcalfe D.D., Escribano L. Diagnosis and treatment of cutaneous mastocytosis in children: practical recommendations. Am. J. Clin. Dermatol., 2011, vol. 12, pp. 259-270.

24. Church M.K., Weller K., Stock P., Maurer M. Chronic spontaneous urticaria in children: Itching for insight. Pediatric Allergy and Immunology, 2011, vol. 22, pp. 1-8.

25. Cugno M., Zanichelli A., Foieni F., Caccia S., Cicardi M. C1-inhibitor deficiency and angioedema: Molecular mechanisms and clinical progress. Trends Mol. Med., 2009, vol. 15, pp. 69-78.

26. Duvanci T., Lugovi -Mihi L., Brekalo A., Situm M., Sinkovi A. Prominent features of allergic angioedema on oral mucosa. Acta Clin. Croat., 2011, vol. 50, pp. 531-538.

27. Ferraro M.F., Moreno A.S., Castelli E.C., Donadi E.A., Palma M.S., Arcuri H.A., Lange A.P., Bork K., Sarti W., Arruda L.K. A single nucleotide deletion at the C1 inhibitor gene as the cause of hereditary angioedema: insights from a Brazilian family. Allergy, 2011, vol. 66, pp. 1384-1390.

28. Franchi L., Eigenbrod T., Mu oz-Planillo R., Nu ez G. The inflammasome: a caspase-1-activation platform that regulates immune responses and disease pathogenesis. Nat. Immunol., 2009, vol. 10, pp. 241-247.

29. Frazer-Abel A., Giclas P.C. Update on laboratory tests for the diagnosis and differentiation of hereditary angioedema and acquired angioedema. Allergy Asthma Proc., 2011, vol. 32, pp. 17-21.

30. Furr J.C., Panda M. Cold-induced urticaria with a familial transmission: a case report and review of the literature. J. Med. Case Rep., 2012, vol. 20, pp. 60-70.

31. Gruber R., Vassilaki I., Zelger B. Concomitant juvenile xanthogranuloma and cutaneous mastocytosis in a 3-year-old Swedish girl: case report and review of the literature. Int. J. Dermatol., 2011, vol. 50, pp. 611-614.

32. Hedrich C.M., Bruck N., Paul D., Hahn G., Gahr M., R sen-Wolff A. Mutation negative familial cold autoinflammatory syndrome in an 8-year-old boy: clinical course and functional studies. Rheumatol. Int., 2012, vol. 32, pp. 2629-2636.

33. Hoffman H.A. Familial Cold Autoinflammatjry syndrome. Journal of the World Allergy Organization., 2008, vol. 17, pp. 131-136.

34. Horikawa T., Fukunaga A., Nishigori C. New concepts of hive formation in cholinergic urticaria. Curr. Allergy Asthma Rep., 2009, vol. 9, pp. 273-279.

35. Ip W.K., Takahashi K., Moore K.J., Stuart L.M., Ezekowitz R.A. Mannose-binding lectin enhances Tolllike receptors 2 and 6 signaling from the phagosome. J. Exp. Med., 2008, vol. 205, pp. 169-181.

36. Jara L.J., Navarro C., Medina G., Vera-Lastra O., Saavedra M.A. Hypocomplementemic urticarial vasculitis syndrome. Curr. Rheumatol. Rep., 2009, vol. 11, pp. 410-415.

37. Khakoo G., Sofianou-Katsoulis A., Perkin M.R., Lack G. Clinical features and natural history of physical urticaria in children. Pediatric Allergy and Immunology, 2008, vol. 19, pp. 363-366.

38. Klebanova Y., LeGrys V., Cooper D. A case of localized adrenergic urticaria mimicking an allergic reaction to a sweat chloride test. Pediatric Pulmonology, 2009, vol. 44, pp. 935-938.

39. Kleewein K., Lang R., Diem A., Vogel T., Pohla-Gubo G., Bauer J.W., Hintner H., Laimer M. Diffuse cutaneous mastocytosis masquerading as epidermolysis bullosa. Pediatr. Dermatol., 2011, vol. 28, pp. 720-725.

40. Kosnik M., Subic T. Add-on montelukast in antihistamine-resistant chronic idiopathic urticaria. Respiratory Medicine, 2011, vol. 105, pp. 84-88.

41. Kotnik V. Complement in skin diseases. Acta Dermatovenerol. Alp. Panonica. Adriat., 2011, vol. 20, pp. 3-11.

42. Krause K., Grattan C.E., Bindslev-Jensen C., Gattorno M., Kallinich T., de Koning H.D., Lachmann H.J., Lipsker D., Navarini A.A., Simon A., Traidl-Hoffmann C., Maurer M. How not to miss autoinflammatory diseases masquerading as urticaria. Allergy, 2012, vol. 67, pp. 1465-1474.

43. Kr pfl L., Maurer M., Zuberbier T. Treatment strategies in urticaria. Expert Opinion on Pharmacotherapy, 2010, vol. 11, pp. 1445-1450.

44. K mmerle-Deschner J.B. Cryopyrin-associated periodic syndrome. Z. Rheumatol., 2012, vol. 71, pp. 199-208.

45. Kurian A., Lee J.K., Vadas P. Schnitzler syndrome with cold-induced urticaria. Journal of Dermatological Case Reports, 2010, vol. 4, pp. 50-53.

46. Kurt E., Aktas A., Aksu K., Keren M., Dokumacioglu A., Goss C.H., Alatas O. Autologous serum skin test response in chronic spontaneous urticaria and respiratory diseases and its relationship with serum interleukin-18 level. Arch. Dermatol. Res., 2011, vol. 303, pp. 643-649.

47. Lange M., Nedoszytko B., G rska A., Ż awrocki A., Sobjanek M., Kozlowski D. Mastocytosis in children and adults: clinical disease heterogeneity. Arch. Med. Sci., 2012, vol. 8, pp. 533–541.

48. Magerl M., Borzova E., Gim nez-Arnau A., Grattan C.E.H., Lawlor F., Mathelier-Fusade P., Metz M., Młynek A., Maurer M. The definition and diagnostic testing of physical and cholinergic urticarias – EAACI/GA2LEN/ EDF/UNEV consensus panel recommendation. Allergy, 2009, vol. 64, pp. 1715-1721.

49. Mamatha G., Balachandran C., Smitha P. Chronic idiopathic urticaria: comparison of clinical features with positive autologous serum skin test. Indian J. Dermatol. Venereol. Leprol., 2008, vol. 74, pp. 105-108.

50. Mecoli C.A., Morgan A.J., Schwartz R.A. Symptomatic dermatographism: current concepts in clinical practice with an emphasis on the pediatric population. Cutis, 2011, vol. 87, pp. 221-225.

51. Mehr S., Jones K.J., Singh-Grewal D., Aksentijevich I., Kakakios A. Chronic urticaria of neonatal onset: a potential sign of autoinflammation. Journal of Paediatrics and Child Health, 2010, vol. 46, pp. 608-610.

52. Metcalfe D.D. Mast cells and mastocytosis. Blood, 2008, vol. 112, pp. 946-956.

53. Metz M., Bergmann P., Zuberbier T., Maurer M. Successful treatment of cholinergic urticaria with antiimmunoglobulin E therapy. Allergy, 2008, vol. 63, pp. 247-249.

54. M ynek A., Zalewska-Janowska A., Martus P., Staubach P., Zuberbier T., Maurer M.. How to assess disease activity in patients with chronic urticaria. Allergy, 2008, vol. 63, pp. 777-780.

55. Nakamizo S., Kurosawa M., Sawada Y., Tokura Y., Miyachi Y., Kabashima K. A case of cholinergic urticarial associated with acquired generalized hypohidrosis and reduced acetylcholine receptors: cause and effect. Clin. Exp. Dermatol., 2012, vol. 26, pp. 114-116.

56. Nakamizo S., Egawa G., Miyachi Y., Kabashima K. Cholinergic urticaria: pathogenesis-based categorization and its treatment options. Journal of the European Academy of Dermatology and Venereology, 2012, vol. 26, pp. 114-116.

57. Nuutinen Р., Harvima I., Ackermann L. Histamine, but not Leukotriene C4, is an essential mediator in cold urticariа. Acta Dermato-Venereologica, 2007, vol. 1, pp. 9-13.

58. Nzeako U.C., Longhurst H.J. Many faces of angioedema: focus on the diagnosis and management of abdominal manifestations of hereditary angioedema. Eur. J. Gastroenterol. Hepatol., 2012, vol. 24, pp. 353-361.

59. Park H., Kim H.S., Yoo D.S., Kim J.W., Kim C.W., Kim S.S., Hwang J.I., Lee J.Y., Choi Y.J. Aquagenic urticaria: a report of two cases. Ann. Dermatol., 2011, vol. 23, pp. 371-374.

60. Perez A., Woods A., Grattan C.E. Methotrexate: a useful steroid-sparing agent in recalcitrant chronic urticaria. Br. J. Dermatol., 2010, vol. 162, pp. 191-194.

61. Posthumus J., Ti ana A., Mozena J.D., Steinke J.W., Borish L. Autoimmune mechanisms in chronic idiopathic urticaria. J. Allergy Clin. Immunol., 2012, vol. 130, pp. 814-816.

62. Powell R.J., Du Toit G.L., Siddique N., Leech S.C., Dixon T.A., Clark A.T. BSACI guidelines for the management of chronic urticaria and angio-oedema. Clinical & Experimental Allergy, 2007, vol. 37, pp. 631-650.

63. Ramam M., Pahwa P. Is cholinergic urticaria a seasonal disorder in some patients. Indian J. Dermatol. Venereol. Leprol., 2012, vol. 78, pp. 190-191.

64. Ray S., Mukherjee A., Chatterjee N., Alam M.A. Neonatal cutaneous mastocytosis. J. Indian Med. Assoc., 2011, vol. 109, pp. 354-355.

65. Ritter M., El-Nour H., Hedblad M.A., Butterfield J.H., Beck O., Stephanson N., Holst M., Giscombe R., Azmitia E.C., Nordlind K. Serotonin and its 5-HT1 receptor in human mastocytosis. Immunopharmacol. Immunotoxicol., 2012, vol. 34, pp. 679-685.

66. Ross J.B., Finlayson L.A., Klotz P.J., Langley R.G., Gaduet R., Thompson K., Churchman S.M., McDermott M.F., Hawkins P.N. Use of anakinra (Kineret) in the treatment of familial cold autoinflammatory syndrome with a 16-month follow-up. J. Cutan. Med. Surg., 2008, vol. 12, pp. 8-16.

67. Sahiner U.M., Civelek E., Tuncer A., Yavuz S.T., Karabulut E., Sackesen C., Sekerel B.E. Chronic urticaria: etiology and natural course in children. Int. Arch. Allergy Immunol., 2011, vol. 156, pp. 224-230.

68. Saini S., Rosen K.E., Hsieh H.J., Wong D.A., Conner E., Kaplan A., Spector S., Maurer M. A randomized, placebo-controlled, dose-ranging study of single-dose omalizumab in patients with H1-antihistamine-refractory chronic idiopathic urticaria. J. Allergy Clin. Immunol., 2011, vol. 128, pp. 567-573.

69. Sajedi V., Movahedi M., Aghamohammadi A., Gharagozlou M., Shafiei A., Soheili H., Sanajian N. Comparison between sensitivity of autologous skin serum test and autologous plasma skin test in patients with Chronic Idiopathic Urticaria for detection of antibody against IgE or IgE receptor (FcεRIα). Iran J. Allergy Asthma Immunol., 2011, vol. 10, pp. 111-117.

70. S nchez J.M., Ram rez R.H., Tamayo L.M., Chinchilla C.F., Cardona R. Cold urticaria: case series and literature review. Biomedica, 2011, vol. 31, pp. 168-177.

71. Sawada Y., Nakamura M., Bito T. Cholinergic urticaria: studies on the muscarinic cholinergic receptor M3 in the anhidrotic and hypohidrotic skin. J. Invest. Dermatol., 2010, vol. 130, pp. 2683-2686.

72. Scadding G.W., Scadding G.K. Recent advances in antileukotriene therapy. Curr. Opin. Allergy Clin. Immunol., 2010, vol. 10, pp. 370-376.

73. Shindo H., Ishii K., Yanase Y., Suzuki H., Hide M. Histamine release-neutralization assay for sera of patients with atopic dermatitis and/or cholinergic urticaria is useful to screen type I hypersensitivity against sweat antigens. Archives of Dermatological Research. 2012, vol. 304, pp. 647-654.

74. Siebenhaar F., Weller K., Blume-Peytavi U., Maurer M. Childhood-onset mastocytosis. Hautarzt, 2012, vol. 63, pp. 104-109.

75. Silpa-archa N., Kulthanan K., Pinkaew S. Physical urticaria: prevalence, type and natural course in a tropical country. J. Eur. Acad. Dermatol. Venereol., 2011, vol. 25, pp. 1194-1199.

76. Torchia D., Francalanci S., Bellandi S., Fabbri P. Multiple physical urticarias. Postgrad Med. J., 2008, vol. 84, pp. e1-e2.

77. Torrelo A., Alvarez-Twose I., Escribano L. Childhood mastocytosis. Curr. Opin. Pediatr., 2012, vol. 24, pp. 480-486.

78. Wakamatsu R., Watanabe H., Suzuki K., Suga N., Kitagawa W., Miura N., Nishikawa K., Yokoi T., Banno S., Imai H. Hypocomplementemic urticarial vasculitis syndrome is associated with high levels of serum IgG4: a clinical manifestation that mimics IgG4-related disease. Intern. Med., 2011, vol. 50, pp. 1109-1112.

79. Yavuz S.T., Sahiner U.M., Tuncer A., Sackesen C. Aquagenic urticaria in 2 adolescents. J. Investig. Allergol. Clin. Immunol., 2010, vol. 20, pp. 624-625.

80. Zitelli K.B., Cordoro K.M. Evidence-based evaluation and management of chronic urticaria in children. Pediatr. Dermatol., 2011, vol. 28, pp. 629-639.

81. Zuberbier T., Asero R., Bindslev-Jensen C., Walter Canonica G., Church M.K., Gim nez-Arnau A. EAACI/GA2LEN/EDF/WAO guideline: definition, classification and diagnosis of urticaria. Allergy, 2009, vol. 64, pp. 1417-1426.


Для цитирования:


Синельникова Н.А., Калинина Н.М., Савенкова Н.Д. ХРОНИЧЕСКАЯ КРАПИВНИЦА В ДЕТСКОМ ВОЗРАСТЕ. ФОРМЫ ХРОНИЧЕСКОЙ КРАПИВНИЦЫ У ДЕТЕЙ. ДИФФЕРЕНЦИАЛЬНАЯ ДИАГНОСТИКА (ЧАСТЬ II). Медицинская иммунология. 2013;15(4):313-324. https://doi.org/10.15789/1563-0625-2013-4-313-324

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Sinelnikova N.A., Kalinina N.M., Savenkova N.D. CHRONIC URTICARIAL IN CHILDHOOD. CLINICAL FEATURES OF CHRONIC URTICARIA IN CHILDREN. DIFFERENTIAL DIAGNOSTICS (PART II). Medical Immunology (Russia). 2013;15(4):313-324. (In Russ.) https://doi.org/10.15789/1563-0625-2013-4-313-324

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ISSN 1563-0625 (Print)
ISSN 2313-741X (Online)