EFFICIENCY OF SOME IMMUNOMODULATORY DRUGS FOR PREVENTION OF RESPIRATORY INFECTIONS AND THEIR COMPLICATIONS IN YOUNG SCHOOLCHILDREN WITH RECURRENT RESPIRATORY INFECTIONS
https://doi.org/10.15789/1563-0625-2013-3-255-262
Abstract
Abstract. We performed a study of efficiency for various immunocorrective drugs in a group of 548 young schoolchildren with recurrent respiratory infections. Frequency of respiratory infections and complication rates were taken as endpoints in this study. It was revealed, that preventive immunocorrection by bacterial lysates or glucosamine muramildipeptide combined with vitamin-mineral complexes may reduce frequency of respiratory infections and their complications at statistically significant levels, as well as to restore some abnormal parameters of immune profile, i.e., CD3, CD4, CD16, induced NBT test, IFNγ, TNFα and IgG. Preventive use of Echinaceae purpurae herbae succus or interferon alpha-2b in combination with vitaminmineral complexes statistically significantly reduces only the frequency of respiratory infections, and partially restores some deficient parameters of immune status (IgG, TNFα, CD16). Introduction of preventive immunocorrection in childhood institutions, with > 90 % coverage of children with recurrent respiratory diseases is associated with a decrease in frequency of respiratory infections not only in this cohort, like as among general population of the same age group.
About the Authors
R. V. Maiorov
Tver State Medical Academy, Tve
Russian Federation
Russian Federation
PhD (Medicine), Associate Professor, Department of Immunology
170100, Sovetskaya str., 4. Phone: 7 (4822) 34-34-60
M. V. Chereshneva
Research Institute of Immunology and Physiology, Russian Academy of Sciences, Ural Branch, Ekaterinburg
Russian Federation
Russian Federation
PhD, MD (Medicine), Professor, Chief Research Associate
S. D. Verzilin
St. Petersburg State Economic University, St. Petersburg
Russian Federation
PhD Candidate
Russian Federation
PhD Candidate
V. A. Chereshnev
Research Institute of Immunology and Physiology, Russian Academy of Sciences, Ural Branch, Ekaterinburg
Russian Federation
Russian Federation
PhD, MD (Medicine), Full Member of Russian Academy of Sciences, Director
References
1. Альбицкий В.Ю., Камаев И.А., Огнева М.Л. Часто болеющие дети. – Н. Новгород: НГМА, 2003. – 180 с. Al`bitskiy V.Yu., Kamaev I.A., Ogneva M.L. Chasto boleyushchie deti [Often ill children]. N. Novgorod, NGMA – NGMA, 2003. 180 p.
2. Баранов А.А. Руководство по амбулаторно-поликлинической педиатрии. – М.: ГЭОТАР-Медиа, 2009. – 592 с. Baranov A.A. Rukovodstvo po ambulatorno-poliklinicheskoy pediatrii [Guidelines for outpatient pediatrics]. Moscow, GEOTAR-Media – GEOTAR-Media, 2009. 592 p.
3. Дронов И.А., Эрдес С.И. Применение лекарственных средств на основе эхинацеи для профилактики и лечения острых респираторных инфекций у детей // Вопросы практической педиатрии, 2011. – № 1. – С. 51-55. Dronov I.A., Erdes S.I. Primenenie lekarstvennykh sredstv na osnove ekhinatsei dlya profilaktiki I lecheniya ostrykh respiratornykh infektsiy u detey [The use of drugs based on echinacea for the prevention and treatment of acute respiratory infections in children]. Voprosy prakticheskoy pediatrii – Problems of Practical Pediatrics, 2011, no. 1, pp. 51-55.
4. Иванова Н.А. Часто болеющие дети: нужны ли иммуномодуляторы // Пульмонология и аллергология. – 2006. – № 4. – C. 18-20. Ivanova N.A. Chasto boleyushchie deti: nuzhny li immunomodulyatory [Often ill children: do we need immunomodulators]. Pul`monologiya i allergologiya – Pulmonology and Allergology, 2006, no. 4, pp. 18-20.
5. Кирюхин А.В., Парфенова Н.А., Максимова Т.А., Шеногина Н.А., Львов А.В., Чумакова М.М., Андронова Т.М. Оптимизация лечения часто и длительно болеющих детей: иммунокоррекция ликопидом // Иммунология. – 2003. – Т. 24, № 1. – С. 47. Kiryukhin A.V., Parfenova N.A., Maksimova T.A., Shenogina N.A., L`vov A.V., Chumakova M.M., Andronova T.M. Optimizatsiya lecheniya chasto i dlitel`no boleyushchikh detey: immunokorrektsiya likopidom [Optimization of treatment and often long ill children immunotherapy Likopid]. Immunologiya – Immunology, 2003, vol. 24, no. 1, p. 47.
6. Майоров Р.В. Факторы риска частых респираторных инфекций у детей Тверской области // Врач-аспирант. – 2011. – № 4 (47). – C. 9-12. Mayorov R.V. Faktory riska chastykh respiratornykh infektsiy u detey Tverskoy oblasti [Risk factors of frequent respiratory infections in children Tver region]. Vrach-aspirant – Doctor-Graduate, 2011, no. 4 (47), pp. 9-12.
7. Майоров Р.В., Михайленко А.А., Черешнева М.В., Черешнев В.А. Психологические и иммунологические изменения у часто болеющих детей // Российский иммунологический журнал. – 2012. – № 2. – С. 178-183. Mayorov R.V., Mikhaylenko A.A., Chereshneva M.V., Chereshnev V.A. Psikhologicheskie I immunologicheskie izmeneniya u chasto boleyushchikh detey [Psychological and immunological changes in sickly children]. Rossiyskiy immunologicheskiy zhurnal – Russian Journal of Immunology, 2012, no. 2, pp. 178-183.
8. Макарова З.С. Эффективность интерферонотерапии часто болеющих детей // Ремедиум Приволжье. – 2010. – № 5. – С. 26-27. Makarova Z.S. Effektivnost` interferonoterapii chasto boleyushchikh detey [Effectiveness of interferon at often ill children]. Remedium Privolzh`e – Remedium Volga, 2010, no. 5, pp. 26-27.
9. Острые респираторные заболевания у детей: лечение и профилактика / Научно-практическая программа Союза педиатров России. – М.: Международный Фонд охраны здоровья матери и ребенка, 2002. – 69 с. Ostrye respiratornye zabolevaniya u detey: lechenie i profilaktika / Nauchno-prakticheskaya programma Soyuza pediatrov Rossii [Acute respiratory infections in children: treatment and prevention. Scientific-practical program of the Union of pediatricians of Russia]. Moscow, Mezhdunarodnyy Fond okhrany zdorov`ya materi I rebenka – International Foundation of maternal and child, 2002. 69 p.
10. Регистр лекарственных средств России. Энциклопедия лекарств / Под ред. Г.Л. Вышковского. – М.: РЛС-Медия, 2012. – 1368 с. Registr lekarstvennykh sredstv Rossii. Entsiklopediya lekarstv / pod red. G.L. Vyshkovskogo [Register medicines in Russia. Encyclopedia of drugs ed. G.L. Vyshkovsky]. Moscow, RLS-Mediya – RLS-Media, 2012. 1368 p.
11. Романцев М.Г., Ершов Ф.И. Часто болеющие дети: современная фармакотерапия. – М.: Гэотар-медиа, 2006. – 192 c. Romantsev M.G., Ershov F.I. Chasto boleyushchie deti: sovremennaya farmakoterapiya [Often ill children: current pharmacotherapy]. Moscow, GEOTAR-Media – GEOTAR-Media, 2006. 192 p.
12. Рулева А.А. Весенний гиповитаминоз у детей // Вопросы современной педиатрии, 2011. – Т. 10, № 2. – С. 155-161. Ruleva A.A. Vesenniy gipovitaminoz u detey [Spring vitamin deficiencies in children]. Voprosy sovremennoy pediatrii – Current Pediatrics, 2011, vol. 10, no. 2, pp. 155-161.
13. Савенкова М.С. Бактериальные лизаты: опыт применения при острых и хронических заболеваниях верхних дыхательных путей // Детские инфекции. – 2011. – Т. 10, № 4. – С. 56-59. Savenkova M.S. Bakterial`nye lizaty: opyt primeneniya pri ostrykh i khronicheskikh zabolevaniyakh verkhnikh dykhatel`nykh putey [Bacterial lysates: experiences of acute and chronic diseases of the upper respiratory tract]. Detskie infektsii – Child infections, 2011, vol. 10, no. 4, pp. 56-59.
14. Самсыгина Г.А. Часто болеющие дети: проблемы патогенеза, диагностики и терапии // Педиатрия. – 2005. – № 1. – C. 66-74. Samsygina G.A. Chasto boleyushchie deti: problemy patogeneza, diagnostiki i terapii [Often ill children: problems of pathogenesis, diagnosis, and therapy]. Pediatriya – Pediatrics, 2005, vol. 1, pp. 66-74.
15. Тутельян В.А., Спиричев В.Б., Шатнюк Л.Н. Коррекция микронутриентного дефицита – важнейший аспект концепции здорового питания населения России // Вопросы питания. – 1999. – № 1. – С. 3-11. Tutel`yan V. A., Spirichev V. B., Shatnyuk L. N. Korrektsiya mikronutrientnogo defitsita – vazhneyshiy aspekt kontseptsii zdorovogo pitaniya naseleniya Rossii [Correction of micronutrient deficiency – the most important aspect of the concept of healthy nutrition in Russia]. Voprosy pitaniya – Nutrition, 1999, no. 1, pp. 3-11.
16. Хаитов Р.М., Ильина Н.И. Аллергология и иммунология. Национальное руководство. – М.: ГЭОТАР-Медиа, 2009. – 659 с. Haitov R.M., Il`ina N.I. Allergologiya i immunologiya. Natsional`noe rukovodstvo [Allergology and Immunology. National leadership]. Moscow, GEOTAR-Media – GEOTAR-Media, 2009. 659 p.
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For citations:
Maiorov R.V., Chereshneva M.V., Verzilin S.D., Chereshnev V.A. EFFICIENCY OF SOME IMMUNOMODULATORY DRUGS FOR PREVENTION OF RESPIRATORY INFECTIONS AND THEIR COMPLICATIONS IN YOUNG SCHOOLCHILDREN WITH RECURRENT RESPIRATORY INFECTIONS. Medical Immunology (Russia). 2013;15(3):255-262. (In Russ.) https://doi.org/10.15789/1563-0625-2013-3-255-262
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