RATIONALE FOR A SPECIFIC THERAPY OF CYTOMEGALOVIRUS INFECTION IN CHILDREN WITH BRONCHIAL ASTHMA
https://doi.org/10.15789/1563-0625-2013-3-269-276
Abstract
Abstract. We propose a protocol of treatment in cases of bronchial asthma with cytomegalovirus (CMV) persistence. This basic therapy is administered depending on the disease severity, according to the National Programme 2009. The treatment includes administration of human immunoglobulin, with dosage according on CMV antibodies titers. The study has revealed that such regimen of antibody administration based on the content of anti-CMV antibodies in bronchial asthma treatment stops active CMV replication in bronchial mucous membrane, alleviates clinical course of the disease, diminishes changes of immune system typical to children suffering from bronchial asthma and CMV reactivation, thus allowing to reduce the volume of basic therapy, along with maintaining control of asthma control.
About the Authors
E. N. Suprun
Far Eastern State Medical University, Khabarovsk Branch, Far Eastern Center of Respiratory Physiology and Pathology, Russian Academy of Medical Sciences, Siberian Branch, Research Institute of Mother and Child Care, Khabarovsk
Russian Federation
Russian Federation
Assistant Professor, Department of Pediatrics, Faculty of Pediatrics; Allergologist
680021, Khabarovsk, Serysheva str., 74-49. Phone: 7 (4212) 25-76-85
V. K. Kozlov
Far Eastern State Medical University, Khabarovsk Branch, Far Eastern Center of Respiratory Physiology and Pathology, Russian Academy of Medical Sciences, Siberian Branch, Research Institute of Mother and Child Care, Khabarovsk
Russian Federation
Russian Federation
PhD, MD (Medicine), Professor, Corresponding Member of the Russian Academy of Medical Sciences, Honored Worker of Science of the Russian Federation, Chief, Department of Pediatrics, Faculty of Pediatrics; Director of Research Institute of Mother and Child Care
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Review
For citations:
Suprun E.N., Kozlov V.K. RATIONALE FOR A SPECIFIC THERAPY OF CYTOMEGALOVIRUS INFECTION IN CHILDREN WITH BRONCHIAL ASTHMA. Medical Immunology (Russia). 2013;15(3):269-276. (In Russ.) https://doi.org/10.15789/1563-0625-2013-3-269-276
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