MOLECULAR GENETIC ANALYSIS OF INTERLEUKIN 4 GENE POLYMORPHISM AMONG TELEUTIANS, SHORIANS, AND CAUCASIANS IN KEMEROVO REGION
https://doi.org/10.15789/1563-0625-2006-5-6-737-740
Abstract
Abstract. An interleukin 4 polymorphism has been studied in Teleutians, Shorians, and Caucasoids living in the Kemerovo Region. The groups of Teleutians and Caucasoids are characterised with even or close-to-even distribution of the IL-4 alleles. The most widespread genotype in populations of Teleutians and Caucasoids was the 2R/3R heterozygosity, and 3R/3R proved to be the mostly rare. These data are indicative for mixing processes among Teleutians in the Kemerovo Region and Siberian Caucasoids. The major IL-4 genotype in Shorian population was 3R/3R, and the heterozygotic genotype 2R/3R took the second position.
About the Authors
A. V. OstaptsevaRussian Federation
A. V. Shabaldin
Russian Federation
V. R. Akhmatianova
Russian Federation
V. I. Minina
Russian Federation
A. N. Glushkov
Russian Federation
V. G. Druzhinin
Russian Federation
I. V. Zorkoltseva
Russian Federation
E. V. Shabaldin
Russian Federation
O. A. Glushkova
Russian Federation
O. S. Makarchenko
Russian Federation
T. N. Ageeva
Russian Federation
References
1. Алексеев В.П. География человеческих рас М. Наука, 1974. – 351 с.
2. Галактионов В. Г. Иммунология. – М.: РИЦ МДК, 2000. – 356 с.
3. Гафаров Н.И. Генетический полиморфизм у телеутов Беловского района Кемеровской области: сывороточные белки и эритроцитарные ферменты // Генетика человека и патология. Сборник научных трудов. – К., 2002. – №6 – С. 25-27.
4. Деренко М. В., Малярчук Б.А., Денисова Г.А., Доржу Х.М., Карамчакова О.Н., Лузина Ф.А., Лотош Е.А., Дамбуева И.К., Ондар У.Н. Полиморфизм диаллельных локусов Y-хромосомы у коренного населения Алтае-Саянского нагорья // Генетика. - 2002. - Т. 38. - № 3. – С. 393-399.
5. Животовский Л.А. Популяционная биометрия. – М.: Высшая школа, 1991. – 245 с.
6. Коненков В.И. Анализ полиморфизма гена IL-4 у здоровых и ВИЧ-инфицированных // Микробиология. – 2001. - №4. – С. 28-32.
7. Лакин Г.Ф. Биометрия. – М.: Высшая школа, 1990. – 352 с.
8. Пол У. Иммунология. – М.: Мир, 1988. – Т. 2. – 456 с.
9. Шабалдин А.В. Иммуногенетические аспекты раннего онтогенеза: Дис. … д-ра мед. наук/ А.В. Шабалдин. – Кемерово, 2005. – 323 с.
10. Mout R., Willemze R., Landegent J.E. Repeat polymorphisms in the interleukin-4 gene (IL4) // Nucleic. Acids. Res. – 1991. – Vol.19. – №13. – P. 3763.
11. Nakayama E. Polymorphism in the Interleukin-4 Promoter Affects Acquisition of Human Immunodeficiency Virus Type Syncytium-Inducing Phenotype // Journal of Virology. – 2000. – Vol. 74. – №12. – p. 5452-5459.
12. Noguchi E. No Association between Atopy/Asthma and the Ile50val Polymorphism of IL-4 Receptor // American journal of Respiratory and Critical Care Medicine. – 1999. – Vol. 160. – №1. – p. 342-345.
13. Unfried G., Tempfer C., Schneeberger C. Interleukin 1 receptor antagonist polymorphism in women with idiopathic recurrent miscarriage // Fertil. Steril. - 2001. – Vol.75. – №4. – P.683.
Review
For citations:
Ostaptseva A.V., Shabaldin A.V., Akhmatianova V.R., Minina V.I., Glushkov A.N., Druzhinin V.G., Zorkoltseva I.V., Shabaldin E.V., Glushkova O.A., Makarchenko O.S., Ageeva T.N. MOLECULAR GENETIC ANALYSIS OF INTERLEUKIN 4 GENE POLYMORPHISM AMONG TELEUTIANS, SHORIANS, AND CAUCASIANS IN KEMEROVO REGION. Medical Immunology (Russia). 2006;8(5-6):737-740. (In Russ.) https://doi.org/10.15789/1563-0625-2006-5-6-737-740