LEVELS OF KEY CYTOKINES, MACROGLOBULINS AND THEIR SPECIFIC IMMUNE COMPLEXES IN BLOOD SERA OF WOMEN TAKING COMBINED ORAL CONTRACEPTIVES
https://doi.org/10.15789/1563-0625-2011-6-635-638
Abstract
Abstract. We investigated effects of combined oral contraceptives (COC) containing low- and microdoses of estrogenic components upon serum levels of macroglobulin family proteins (alpha-2-macroglobulin, α2-MG, and pregnancy-associated alpha-2-glycoprotein, α2-PAG), their immune complexes with IgG, as well as concentrations of some cytokines (IL-1β, IL-6, TNFα, IFNγ). It was shown that cytokine levels did not differ with control, whereas α2-MG concentrations showed a time-dependent decrease in a group of women taking COC with microdoses of estrogens, and α2-PAG levels increased tenfold, independent on dosage and time of COC application. Meanwhile, contents of PAG-IgG complexes exhibits a gradual decrease, along with increase in MG-IgG. Considering PAG as a marker of normal and malignant proliferation, we suggest, that the levels of α2-PAG may be useful in monitoring of women taking COC, in order to predict high risk of pathological proliferation by evaluation of individuals with elevated α2-PAG levels. (Med. Immunol., 2011, vol. 13, N 6, pp 635-638)
About the Authors
V. N. ZorinaRussian Federation
E. V. Keremetskaya
Russian Federation
L. G. Bagenova
Russian Federation
R. M. Zorina
Russian Federation
References
1. Зорин Н.А., Жабин С.Г., Лыкова О.Ф., Зорина Р.М., Горин В.С., Белогорлова Т.И., Чирикова Т.С., Краюшкина Н.А. Белки плазмыи сыво ротки крови доноров // Клин. лаб. диагн. – 1992. – № 9-10. – С. 13-15.
2. Зорина В.Н., Зорина Р.М., Левченко В.Г.,Воронина Е.А, Зорин Н.А. Концентрация комплексов макроглобулин – IgG, как возможныйкритерий для прогнозирования гестоза и оценки степени его тяжести // Клин. лаб. диагн. – 2001. – № 8. – С. 48-49.
3. Зорина В.Н., Промзелева Н.В., Третьякова Т.В., Баженова Л.Г., Рябичева Т.Г., Архипова С.В., Зорина Р.М. Изменения цитокиновогопрофиля, а также уровней белков транспортеровпри пролиферативных заболеваниях придатковматки // Медицинская иммунология. – 2009. – № 11 (2-3). – С. 185-191.
4. Armstrong P.B., Quigley J.P. Alpha-2macroglobulin: an evolutionary conserved arm of the innate immune system // Dev. Comp. Immunol. – 1999. – Vol. 23. – P. 375-390.
5. Birkenmeier G. Targetting the proteinaseinhibitor and immune modulatory function of human alpha 2-macroglobulin // Mod. Asp. Immunobiol. – 2001. – Vol. 2. – P. 32-36.
6. Bjelic-Radisic V., Petru E. Hormonal contraception and breast cancer risk // Wien Med Wochenschr. – 2010. – Vol. 160, N 19-20. – P. 483-486.
7. Bonny A.E., Secic M., Cromer B.A. Relationship between Weight and Bone Mineral Density in Adolescents on Hormonal Contraception // J. Pediatr. Adolesc. Gynecol. – 2011. – Vol. 24, N 1. – P. 35-38.
8. Chiabrando G.A., Vides M.A., Sanchez M.C. Differential binding properties of human pregnancy zone protein- and alpha2-macroglobulin-proteinase complexes to low-density lipoprotein receptor-related protein // J. Arch. Biochem. Biophys. – 2002. – Vol. 398, N 1. – P. 73-78.
9. Crawford J.C., Boulet M., Drea C.M. Smelling wrong: hormonal contraception in lemurs alters critical female odour cues // Proc. Biol. Sci. – 2011. –Vol. 278, N 1702. – P. 122-130.
10. Kriplani A., Periyasamy A.J., Agarwal N., Kulshrestha V., Kumar A., Ammini A.C. Effect of oral contraceptive containing ethinyl estradiol combined with drospirenone vs. desogestrel on clinical and biochemical parameters in patients with polycystic ovary syndrome // Contraception. – 2010. – Vol. 82, N 2. – P. 139-146.
11. Lukaszewicz M., Mroczko B., Szmitkowski M. Clinical significance of interleukin-6 (IL6) as a prognostic factor of cancer disease // Pol. Arch. Med. Wewn. – 2007. – Vol. 117, N 5-6. – P. 247-251.
12. Palan P.R., Strube F., Letko J., Sadikovic A., Mikhail M.S. Effects of oral, vaginal, and transdermal hormonal contraception on serum levels of coenzyme q(10), vitamin e, and total antioxidant activity // Obstet Gynecol Int. – 2010. – pii: 925635.
13. Petersen С.М. Alpha 2-macroglobulinand pregnancy zone protein/ Serum level, Alpha 2-macroglobuline receptors, cellular synthesis and aspects of function relation to immunology // Dan. Med. Bull. – 1993. – Vol. 40. – P. 409-446.
14. Wu S.M., Patel D.D., Pizzo S.V. Oxidized alpha2-macroglobulin (alpha 2M) differentially regulates receptor binding by cytokines/growth factors: implications for tissue injury and repair mechanisms in inflammation // J. I
Review
For citations:
Zorina V.N., Keremetskaya E.V., Bagenova L.G., Zorina R.M. LEVELS OF KEY CYTOKINES, MACROGLOBULINS AND THEIR SPECIFIC IMMUNE COMPLEXES IN BLOOD SERA OF WOMEN TAKING COMBINED ORAL CONTRACEPTIVES. Medical Immunology (Russia). 2011;13(6):635-638. (In Russ.) https://doi.org/10.15789/1563-0625-2011-6-635-638