LEVELS OF KEY CYTOKINES, MACROGLOBULINS AND THEIR SPECIFIC IMMUNE COMPLEXES IN BLOOD SERA OF WOMEN TAKING COMBINED ORAL CONTRACEPTIVES
https://doi.org/10.15789/1563-0625-2011-6-635-638
Abstract
Abstract. We investigated effects of combined oral contraceptives (COC) containing low- and microdoses of estrogenic components upon serum levels of macroglobulin family proteins (alpha-2-macroglobulin, α2-MG, and pregnancy-associated alpha-2-glycoprotein, α2-PAG), their immune complexes with IgG, as well as concentrations of some cytokines (IL-1β, IL-6, TNFα, IFNγ). It was shown that cytokine levels did not differ with control, whereas α2-MG concentrations showed a time-dependent decrease in a group of women taking COC with microdoses of estrogens, and α2-PAG levels increased tenfold, independent on dosage and time of COC application. Meanwhile, contents of PAG-IgG complexes exhibits a gradual decrease, along with increase in MG-IgG. Considering PAG as a marker of normal and malignant proliferation, we suggest, that the levels of α2-PAG may be useful in monitoring of women taking COC, in order to predict high risk of pathological proliferation by evaluation of individuals with elevated α2-PAG levels. (Med. Immunol., 2011, vol. 13, N 6, pp 635-638)
About the Authors
V. N. Zorina
ГОУ ДПО Новокузнецкий государственный институт усовершенствования врачей Росздрава, г. Новокузнецк
Russian Federation
Russian Federation
E. V. Keremetskaya
ГОУ ДПО Новокузнецкий государственный институт усовершенствования врачей Росздрава, г. Новокузнецк
Russian Federation
Russian Federation
L. G. Bagenova
ГОУ ДПО Новокузнецкий государственный институт усовершенствования врачей Росздрава, г. Новокузнецк
Russian Federation
Russian Federation
R. M. Zorina
ГОУ ДПО Новокузнецкий государственный институт усовершенствования врачей Росздрава, г. Новокузнецк
Russian Federation
Russian Federation
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For citations:
Zorina V.N., Keremetskaya E.V., Bagenova L.G., Zorina R.M. LEVELS OF KEY CYTOKINES, MACROGLOBULINS AND THEIR SPECIFIC IMMUNE COMPLEXES IN BLOOD SERA OF WOMEN TAKING COMBINED ORAL CONTRACEPTIVES. Medical Immunology (Russia). 2011;13(6):635-638. (In Russ.) https://doi.org/10.15789/1563-0625-2011-6-635-638
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