IN VITRO EFFECTS OF MEVASTATIN AND BIOLOGICAL PREPARATIONS UPON ACTIVATION OF EBV-SPECIFIC CD4+T LYMPHOCYTES FROM THE PATIENTS WITH RHEUMATOID ARTHRITIS
https://doi.org/10.15789/1563-0625-2011-2-3-285-290
Abstract
Abstract. Present study concerned in vitro modifying effects of mevastatin, infliximab, r-met-Hu-sTNF-RI and IL-1ra upon antigen-induced activation of peripheral EBV-specific CD4+T-lymphocytes from the patients with rheumatoid arthritis (RA). When compared with healthy persons, the RA patients have shown significantly decreased concentrations of antigen-activated EBV-specific CD4+T-cells. In healthy donors, mevastatin, infliximab, r-met-Hu-sTNF-RI and IL-1ra did not influence the CD4+, IFNγ+ cell concentrations. Neither there were any effects of the abovementioned drugs upon the numbers of EBV-specific CD4+T-cell subset among cultured mononuclear cells from RA patients. Thus, the cells from RA patients exhibit a decreased in vitro antigen-induced activation of EBV-specific CD4+T-cells, whereas statins and biological agents do not promote suppression of EBV-specific activation of CD4+T-cells. (Med. Immunol., 2011, vol. 13, n 2-3, pp 285-290)
About the Authors
I. V. Shirinsky
Российская академия медицинских наук Научно-исследовательского института клинической иммунологии СО РАМН, г. Новосибирск
Russian Federation
Russian Federation
V. S. Shirinsky
Российская академия медицинских наук Научно-исследовательского института клинической иммунологии СО РАМН, г. Новосибирск
Russian Federation
Russian Federation
C. A. Dinarello
Division of Infectious Diseases, University of Colorado Health Sciences Center, Denver
Russian Federation
Russian Federation
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Review
For citations:
Shirinsky I.V., Shirinsky V.S., Dinarello C.A. IN VITRO EFFECTS OF MEVASTATIN AND BIOLOGICAL PREPARATIONS UPON ACTIVATION OF EBV-SPECIFIC CD4+T LYMPHOCYTES FROM THE PATIENTS WITH RHEUMATOID ARTHRITIS. Medical Immunology (Russia). 2011;13(2-3):285-290. (In Russ.) https://doi.org/10.15789/1563-0625-2011-2-3-285-290
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