DYNAMICS OF CD14+СD16+ MONOCYTE SUBPOPULATIONS IN COMPLICATION-FREE SYSTEMIC INFLAMMATORY RESPONSE FOLLOWING CORONARY ARTERY BYPASS GRAFT SURGERY
https://doi.org/10.15789/1563-0625-2012-4-5-391-398
Abstract
Abstract. Time dynamics of CD14 and СD16 antigen expression on the surface of peripheral blood monocytes and serum cytokine contents was evaluated at different terms after surgical intervention in patients undergoing on-pump coronary artery bypass graft surgery. An association has been shown between severity of organ dysfunctions, as assessed by SOFA scores, and concentrations of IL-6 and IL-10 during early postoperative terms. On day +1 after surgery, the monocyte subpopulation profile was changed, due to relative decrease in CD14hiCD16– and increase in CD14hiCD16+. Expression of CD14 on the surface of CD14hiCD16–is reduced, along with increased expression of CD16 receptor. The observed association between relative CD14hiCD16– contents, CD16 expression level on CD14hiCD16+ monocyte subpopulation, and SOFA scores suggest a significant contribution of above-mentioned subpopulations to clinical course at early terms after surgical intervention.
About the Authors
V. G. Matveeva
НИИ комплексных проблем сердечно-сосудистых заболеваний СО РАМН, г. Кемерово
Russian Federation
Russian Federation
A. S. Golovkin
НИИ комплексных проблем сердечно-сосудистых заболеваний СО РАМН, г. Кемерово
Russian Federation
Russian Federation
I. V. Kudryavtsev
НИИ экспериментальной медицины СЗО РАМН, Санкт-Петербург
Russian Federation
Russian Federation
E. V. Grigoriev
НИИ комплексных проблем сердечно-сосудистых заболеваний СО РАМН, г. Кемерово
Russian Federation
Russian Federation
M. N. Chernova
НИИ комплексных проблем сердечно-сосудистых заболеваний СО РАМН, г. Кемерово
Russian Federation
Russian Federation
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Review
For citations:
Matveeva V.G., Golovkin A.S., Kudryavtsev I.V., Grigoriev E.V., Chernova M.N. DYNAMICS OF CD14+СD16+ MONOCYTE SUBPOPULATIONS IN COMPLICATION-FREE SYSTEMIC INFLAMMATORY RESPONSE FOLLOWING CORONARY ARTERY BYPASS GRAFT SURGERY. Medical Immunology (Russia). 2012;14(4-5):391-398. (In Russ.) https://doi.org/10.15789/1563-0625-2012-4-5-391-398
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