GENETIC POLYMORPHISMS OF CD14, TNFα AND FCGR2A IN THE PATIENTS WITH INFLUENZA A H1N1 IN TRANSBAIKALIA REGION
https://doi.org/10.15789/1563-0625-2011-1-83-86
Abstract
Abstract. Relative frequencies of CD14 C-159T, TNFα G-308A and FCGR2A His166Arg genetic polymorphisms were studied in the patients with pandemic influenza A H1N1 in Transbaikalia Region. We have revealed that prevalences of allelic TNFα G-308A and CD14 C-159T variants were identical among the patients and in control group. With CD14 C-159T polymorphism, a C allele proved to be associated with severe and complicated clinical course of disease. The [CD14 (159СС); FCGR2A (166Arg/Arg)] haplotype regictered in two cases, was associated with fulminant course and fatal outcomes of the disease. (Med. Immunol., 2011, vol. 13, N 1, pp 83-86)
About the Authors
V. V. Petrov
ГОУ ВПО «Читинская государственная медицинская академия», г. Чита
Russian Federation
Russian Federation
N. N. Strambovskaya
ГОУ ВПО «Читинская государственная медицинская академия», г. Чита
Russian Federation
Russian Federation
A. V. Govorin
ГОУ ВПО «Читинская государственная медицинская академия», г. Чита
Russian Federation
Russian Federation
Yu. A. Vitkovsky
ГОУ ВПО «Читинская государственная медицинская академия», г. Чита
Russian Federation
Russian Federation
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Review
For citations:
Petrov V.V., Strambovskaya N.N., Govorin A.V., Vitkovsky Yu.A. GENETIC POLYMORPHISMS OF CD14, TNFα AND FCGR2A IN THE PATIENTS WITH INFLUENZA A H1N1 IN TRANSBAIKALIA REGION. Medical Immunology (Russia). 2011;13(1):83-86. (In Russ.) https://doi.org/10.15789/1563-0625-2011-1-83-86
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